Light regimen, anovulation, and risk of malignant neoplasms of the female reproductive system:the mechanisms of link and prevention

Abstract

This article contains own and literature data on stimulating influence of constant light illumination on the risk of the development of anovulation, hyperplastics processes and cancers of the female reproductive system organs (mammary gland, endometrium, and ovaries) in the laboratory animals and women. Contrary, the light deprivation obstacles to the cancer development. The ata on the key role of the inhibition of production of pineal hormone melatonin in the pathology that developed under the effect of light-at-night as well as on the possible prevention of this pathology with melatonin and pineal peptides are reported.

Keywords

constant light illumination / anovulation / cancer / mammary gland / endometrium / ovaries / melatonin / peptides / epiphysis

References

[1] Анисимов В. Н. Канцерогенез у крысс персистирующим эструсом // Вопр. онкологии. — 1971. - 8. - С. 67-75.

[2] Анисимов В. Н. Эпифиз (шишковидная железа) и опухолевый рост//Вопр. онкол. — 1980. — Т. 26. —№ 8. - С. 97-105.

[3] Анисимов В. Н., Арутюнян А. В., Хавинсон В. X. Мелатонин и эпиталамин угнетают процесс перекисного окисления липидов у крыс//Доклады РАН. - 1996. - Т. 348. - С. 765-767.

[4] Анисимов В. Н., Батурин Д. А., Айламазян Э. К. Эпифиз, свет и рак молочной железы//Вопр. онкологии. — 2002. — 48. — № 4-5. — С. 524-535.

[5] Анисимов В. Н., Хавинсон В. X., Алимова И. Н. и соавт. Эпиталон угнетает развитие опухолей и экспрессию HER-2/neu онкогена в опухолях молочной железы у трансгенных мышей с ускоренным старением//Бюлл. экспер. биол. мед. - 2002. - Т. 133. - № 2. - С. 199-203.

[6] Беспалов В. Г., Александров В. А., Анисимов В. Н., Морозов В. Г., Хавинсон В. X. Влияние полипептидных факторов тимуса, эпифиза, костного мозга и переднего гипоталамуса на реализацию трансплацентарного канцерогенеза//Экспер. онкол. — 1984. — Т. 6. — № 5. — М.С.27-30. Злокачественные новообразования в России в 2000 году (заболеваемость и смертность)/Под ред. В.И. Чиссова, В. В. Старинского. — М.: МНИОИ им. П. А. Герцена. — 2002. - 264 с.

[7] Ирд Е. А. Фолликулярные кисты яичников и дисгормональные опухоли. Л.: Медицина. —1966. —136 с.

[8] Кураласов А. К. Экспериментальные основы использования искусственного фоторежима для лечения рака молочной железы в условиях Казахстана. Автореферат дисс.... докт. мед. наук//М.: ВОНЦ АМН СССР. - 1990. - 44 с.

[9] Лазарев Н. И., Ирд Е. А., Смирнова И. О. Экспериментальные модели эндокринных гинекологических заболеваний. М.: Медицина. — 1976. - 175 с.

[10] Ром-Бугославская Е. С., Бондаренко Л. А., Сомова Е. В., Комарова И. В. Роль пинеальной железы в развитии атеросклероза. Влияние круглосуточного совещения на некоторые стороны патогенеза атеросклероза//Пробл. старения и долголетия. — 1993. — Т. 3. — № 2. — С. 91-97.

[11] Смирнова И. О. Экспериментальные основы лечения мастопатии микродозами йода//Автореф. дисс. канд. мед. наук. М.: ВОНЦ АМН СССР. - 1966. - 16 с.

[12] Хаецкий И. К. Влияние гипоталамо-гипофизарных нарушений, вызываемых постоянным освещением, на развитие индуцированных опухолей молочных желез у крыс//Вопросы экспер. онкологии. Киев: Здоров'я. — 1965. Вып. 1. — С. 87—93.

[13] Albarran М. Т., Lopez-Burillo S., Pablos М. /., et al. Endogenous rhythms of melatonin, total antioxidant status and superoxide dismutase activity in several tissues of chick and their inhibition by light//J. Pineal Res. — 2001. - Vol. 30. - P. 227-233.

[14] Alexandrov V. A., Anisimov V. N., Belous N. M., Vasileva I. A., Matcan V. B. The inhibition of the transplacental blastomogenesis effect of nitrosomethylurea by postnatal administration of buformin to rats// Carcinogenesis. — 1980. — Vol. — N 12. — P. 975-978.

[15] Ames B. N., Shigenaga M. K., Hogen T. M. Oxidants, antioxidats, and the degenerative diseases of aging//Proc. Natl. Acad. Sci. USA. - 1993. - Vol. 90. — P. 7915-7920.

[16] Anisimov V. N. «Carcinogenesis and Aging». Vol. 2. Boca Raton, Florida: CRC Press. — 1987. — 148 p.

[17] Anisimov V.N., Arutjunyan A.V., Khavinson V. Kh. Effects of pineal peptide preparation Epithalamin on free radical processes in humans and animals//Neuroendocrinol Lett. - 2001. - Vol. 22. - P. 11-20.

[18] Anisimov V. N., Khavinson V. Kh., Alimova I. N., Provinciali M., Mancini R., Franceschi C. Epitalon inhibits development of tumors and expression of HER-2/neu oncogene in mammary tumors in transgenic mice with accelerated aging//Bull. Exp. Biol. Med. — 2002. — 132: 56-59.

[19] Anisimov V. N., Khavinson V. Kh., Morozov V. G. Carcinogenesis and aging. IV. Effect of low-molecular weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice//Mech. Ageing Dev.— 1982. — Vol. 19. - P. 245-258.

[20] Anisimov V. N., Khavinson V. Kh., Popovich I. G., Zabeahinski M. A. Inhibitory effect of peptide epitalon on colon carcinogenesis iduced by 1, 2-dimethylhydrazine in rats//Cancer Lett. - 2002. - Vol. 183. - P. 1-8.

[21] Anisimov V. N., Popovich I. G., Shtylik A. V. et al. Melatonin and colon carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 2-dimethylhydrazine in rats//Exp. Toxicol. Pathol. —Vol. 52.-P. 71-76.

[22] Anisimov V. N., Zhukova О. V., Beniashvili D. Sh. et al. Light deprivation, electromagnetic fields and mammary carcinogenesis//Adv. Pineal Res. — 1994. — Vol. 7. — P. 229—234.

[23] Arendt J. «Melatonin and the Mammalian Pineal Gland». London: Chapman & Hall. — 1995. — 331 p.

[24] Aschheim P. Aging in the hypothalamic-hypophyseal- ovarian axis in the rat. In: Everitt AV, Burgess JA, eds. Springfield: Charles C Tomas. — 1976. — P. 376-392.

[25] Aschoff J., von Saint Paul U., Wever R. Die Lebesdauer von Fliegen inter dem Einfluss von Zeitverschiebungen// Naturwissenschaften. — 1971. — Vol. 58. — P. 574.

[26] Baturin D. A., Alimova I. N., Anisimov V. N. et al. Effect of light regime and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression//Neuroendocrinol. Lett. — 2001. — Vol. 22. — P. 439-445.

[27] Beniashvili D. S., Benjamin S., Baturin D.A., Anisimov V. N. Effect of light/dark regimen on N-nitrosoethylurea- induced trsnsplacental carcinogenesis in rats. Cancer Letters. - 2001. - Vol. 163. - P. 51-57.

[28] Benot S., Molinero P., Soutto M., Gobema R., Guerrero J. M. Circadian variation in the rat serum total antioxidant status: correlation with melatonin levels//J. Pineal Res. — 1998. - Vol. 25. - P. 1-4.

[29] Blask D. E. An overview on the neuroendocrine regulation of experimental tumor growth by melatonin and its analogues and the therapeutic use of melatonin in oncology//In: Bartsch C., Bartsch H., Blask D.E. et al. (eds.). The Pineal Gland and Cancer. Neuroimmunoendocrine Mechanisms in Malignancy. Berlin: Springer. — 2001. — P. 309-342.

[30] Blask D. E., Hill S. M. Melatonin and cancer: basic and clinical aspects//In: Miiles A., Philbrick D. R. S., Thompson C., Eds. Melatonin Clinicl Perspectives. New York: Oxford Univ. Press. - 1988. - P. 128-173.

[31] Blask D. E., Vaughan M. K., Reiter R. E. Pineal peptides and reproduction//In: The Pineal Gland. Relkin R., ed. Amsterdam: Elsevier. — 1983. — P. 201—224.

[32] Brainard G. C., Kaver R., Kheifets L. I. The relationship between electromagnetic field and light exposure to melatonin and breast cancer risk: a review of the relevant literature//J. Pineal Res. — 1999. — Vol. 26. — P. 65-100.

[33] Cancer Incidence in Five Continents Volume VI/ Parkin D. M., Muir C. S., Whelan S. L., Gao Y. T., Ferlay J., Powell J. (eds.). — IARC Sci. Publ. N. 120. — IARC. - Lyon. - 1992.

[34] Cohen M., Lippman M., Chabner R. Role of pineal gland in aetiology and treatment of breast cancer/ Lancet. — 1978. - Vol. 2. - P. 814-816.

[35] Davis S., Mirck D. K., Stevens R. G. Night shift work, light at night, and risk of breast cancer//J. Natl. Cancer Inst. - 2001. - Vol. 93. - P. 1557-1562.

[36] Deerberg F., Bartsch C., Pohlmeyer G., Bartsch H. Effect of melatonin and physiological epiphysectomy on the development of spontaneous endometrial carcinoma in BDII/HAN rats//Cancer Biother. Raiolpharmacol. — 1997. - Vol. 12. - P. 420.

[37] Dilman V. M. «Development, Aging and Disease. A New Rationale for and intervention Strategy». Chur, Siwtzerland: Harwood Acad. Press. — 1994. — 380 p.

[38] Dilman V. M., Anisimov V. N. Hypothalamic mechanisms of ageing and of specific age pathology — I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system//Exp. Gerontol. - 1979. - Vol. 14. - P. 161-174.

[39] Feychting M., Oosterlund B., Ahlbom A. Reduced cancer incidence among the blind//Epidemiology. — 1998. — Vol. 9. - P. 490-494.

[40] Fujini Y., Mizroue T., Izumi H. Et al. Job stress and mental health among permanent night workers//J. Occup. Healt. - 2001. - Vol. 43. - P. 301-306.

[41] Graham C, Cook M. R., Gerkovich M. M., Sastre A. Examination of the Melatonin hypothesis in women exposed at night to EMF or bright light//Environ. Health Perspect. - 2001. - Vol. 109. - P. 501-507.

[42] Gupta D., Attanasio A., Reiter R. J., eds. The Pineal Gland and Cancer. London: Brain Research Promotion. — 389 p.

[43] Hahn R. A. Profound bilateral blindness and the incidence of breast cancer//Epidemiology. — 1991. — Vol. 2. — P. 108-210.

[44] Hamilton T., Sneddon A. Environmental light and DMBA- induced rat mammary tumours//Br. J. Surg. — 1968.-Vol. 55.-P. 71-76.

[45] Hansen J. Increased breast cancer risk among women who work predominantly at night//Ann. Epidemiology. — -Vol.12.-P. 74-77.

[46] Ivanisevic-Milovanovic О. K., Demajo M., Karakasevic A., Pantic C. The effect of constant light on the concentration of catecholamines of the hypothalamus and adrenal glands, circulatory adrenocorticotropin hormone and progesterone// J. Endocr.Invest. - 1995. - Vol. 18. - P. 378-383.

[47] Jochle W. Trends in photophysiologic concepts//Ann. N. Y. Acad. Sci. - 1964. - Vol. 117. - P. 88-104.

[48] Kawachi I., Colditx G. A., Stampfer M. J. et al. Prospective study of shift work and risk of coronary heart disease in women//Circulation. — 1995. — Vol. 92. — P. 3178-318.

[49] Khavinson V., Goncharova N., Lapin B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys // Neuroendocrinol. Lett. - 2001. - Vol. 22. - P. 251-254.

[50] Khavinson V. Kh., Izmailov D. M., Obukhova L. K, Malinin V. V. Effect of epithalon on the lifespan increase in Drosophila melanogaster//Mech. Ageing Dev. — 2000. — Vol. 120. -P. 141-149.

[51] Khavinson V. Kh., Morozov V. G., Anisimov V. N. Experimental studies of the pineal gland preparation epithalamin//In: Bartsch C., Bartsch H., Blask D.E. et al.(eds.). The Pineal Gland and Cancer. Neuroimmunoendocrine Mechanisms in Malignancy. Berlin: Springer. — 2001. — P. 294—306.

[52] Kothari L. Influence of chronic melatonin on 9, 10-dimethyl-1, 2-benzanthrazene-induced mammary tumors in female Holtzamn rats exposed to continuous light// Oncology. - 1987. - Vol. 44. - P. 64-66.

[53] Mediavilla M. D., Guezmez A., Ramos S., Kothari L., Garijo F., Sanchez-Barcelo E.J. Effect of melatonin on mammary gland lesions in transgenic mice overexpressing N-ras proto-oncogene//J. Pineal Res. — 1997. — Vol. 22. — P. 86-94.

[54] Morozov V. G., Khavinson V. Kh. Peptide Bioregulators (25-years Experience of Experimental and Clinical Study). St.Petersburg: Nauka. — 1996.

[55] Panzer A., Viljoen M. The validity of melatonin as an oncostatic agent. J. Pineal Res. — 1997. — Vol. 22. — P. 184-202. The Pineal Gland and Cancer. Neuroimmunoendocrine Mechanisms in Malignancy/Bartsch C., Bartsch H., Blask D.E. et al., eds. Berlin: Springer. — 2001. — 589 p.

[56] Pukkala E., Auvinen H., Wahlberg G. Incidence of cancer among Finnish airline cabin attendants, 1967—92// Br. Med. J. - 1995. - Vol. 311. - P. 649-652.

[57] Pukkala E., Verkasalo P. K., Ojamo M., Rudanko S.L. Visual impairment and cancer: a population-based cohort study in Finland//Cancer Causes Control. — 1999. — Vol. 10. - P. 13-20.

[58] Rafnsson V., Tulinius H., Jonasson J., Hrafnkelsson J. Risk of breast cancer in female flight attendants: a population-based study (Iceland)//Cancer Cause Control. — 2001.-Vol. 12.-P. 95-101.

[59] Rao G. N., Ney E., Herbert R. A. Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene//Breast Cancer Res. Treatment. - 2000. - Vol. 64. - P. 287-296.

[60] Reiter R. J. Pineal melatonin: cell biology of its synthesis and of its physiological interactions//Endocrin. Rev. — 1991.-Vol. 12.-P. 151-180.

[61] Reiter R. J., Melchiorri D., Sewerinek E., Poegeller B., Barlow-Walden L., Chuang J., Ortiz G. G., Acuna- Castroviejo D. A review of the evidence supporting melatonin’s role as an antioxidant//.J. Pineal Res. — Vol. 18.-P. 1-11.

[62] Rossmanith W. G. Gonadotropin secretion during aging in women: review article//Exp. Gerontol. — 1996. — Vol. 30. - P. 369-381.

[63] Sanchez-Barcelo E. J., Cos S., Mediavilla M. D. Influence of pineal function on the initiation and growth of hormone-dependent breast tumors. Possible mechanisms. In: Gupta D., Attanasio A., Reiter R.J., eds. The Pineal Gland and Cancer. London: Brain Research Promotion. — 1988. - P. 221-232.

[64] Seshardi R., Subramanian A., Kothari L. Effect of neonatal pineal ablation on estradiol receptors in mammary glands of rats housed under varying photoperiods//Indian J. Exp. Biol. - 1992. - Vol. 30. - P. 162-164.

[65] Schernhammer E. S., Laden E., Speizer F. E. et al. Rotating night shifts and risk of breast cancer in women participating in the nurses’ health study//J. Natl. Cancer Inst. - 2001. - Vol. 93. - P. 1563-1568.

[66] Sheba V., Sharma V. K., Shubha K., Chandrashekaran M. K., Joshi A. The effect of different light regimes on sult life span in Drosophila melanogaster is partly nediated through reproductive output. J Biol Rhythms. — 2000. — 15: 380—392.

[67] Stevens R. G. Circadian disruption and breast cancer//In: Bartsch C., Bartsch H., Blask D.E. et al. (eds.). The Pineal Gland and Cancer. Neuroimmunoendocrine Mechanisms in Malignancy. Berlin: Springer. — 2001. — P. 511-517.

[68] Stevens R. G., Wilson B. W., Anderson L. I. The Melatonin Hypothesis. Breast Cancer and Use of Electric Power. — Columbus: Buttele Press. — 1997. — 760 p.

[69] Subramanian A., Kothari L. Melatonin, a supressor of spontaneous murine mammary tumors//J. Pineal Res. — 1991. - Vol. 10. - P. 136-140.

[70] Tamarkin L., Cohen D., Roselle C., Reichert M. Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat//Cancer Res. — 1981. — Vol. 41. — P. 4432-44З6.

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