Adenomyosis as an optional risk factor for uterine cancer

Abstract

The problem of adenomyosis malignization is controversial and insufficiently explored. Rate of the malignant transformation of adenomyosis varies from O.l to 24 per cent; as a rule, malignization of the stromal component of adenomyosis is described, works containing cancerous transformation description are isolated ones. Comparative clinical and morphological and immunohistochemical investigation of the cancerous transformation of adenomyosis (6 observations), endometrium cancer in combination with adenomyosis (16 observations), and typical adenomyosis (9 observations) is carried out. Obtained data indicate the precancerous optional significance of adenomyosis, risk of which increases in senior age groups. Endometrial adenocarcinoma does not exhibit a tendency to invasive growth into adenomyosis nidi; combined independent development of endometrium cancer and adenomyosis malignization with exo- and endophyte growth is possible, which determines the hypodiagnostics of malignizated adenomyosis. Morphological verification of malignizated adenomyosis demands comprehensive clinical and morphological investigation with broad study of operating material and with taking into consideration the stages of cancerous transformation morphogenesis established during the work. Late diagnostics and inadequate surgical treatment diagnose the unfavorable prognosis.

Keywords

uterus / adenomyosis / cancerous transformation / morphological diagnosis

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