Papillomaviral infection: risk factors of cervical neoplastic progression

Abstract

Human papillomavirus (HPV) plays the important role in the etiology of the cervical cancer. Considering that the cancer is very rare consequence of HPV-infection and even the high-grade lesions may spontaneously regress, search for the factors capable of predicting disease progression is of great significance. In the present review results of researches into risk factors of developing cervical cancer are summarized. Some virus-associated factors, such as infection with oncogenic types and variants of human papillomavirus, viral load, integration of viral DNA into cell genome, as well as host factors - polymorphism of p53 gene encoding a key apoptotic protein, loss of heterozygosity, tumor suppressor genes hypermethylation - are analyzed in terms of their prognostic value.

Keywords

human papillomavirus / cervical cancer / neoplastic progression / risk factors

References

[1] Барышников А.Ю., Шишкин Ю.В. Иммунологические проблемы апоптоза. - М., 2002. - 318 с.

[2] Калинин В.Л. Введение в молекулярную вирусологию. - СПб.: Изд-во СПбГТУ, 2002. - 302 с.

[3] Киселев Ф.Л., Киселева Н.П., Кобзева В.К. и др. Статус ДНК вируса папиллом человека в опухолях шейки матки// Мол. Биол. Клетки - 2001. — Т. 35. — С. 470-476.

[4] Auborn K.J., Woodworth С., DiPaolo J.A., Bradlow H.L. The interaction between HPV infection and estrogen metabolism in cervical carcinogenesis// Int. J. Cancer. - 1991. - Vol. 49. - P. 867-869.

[5] Badaracco G., Venuti A., Sedati A., Marcante M.L. HPV16and HPV18 in genital tumors: significantly different levels of viral integration and correlation to tumor invasiveness// J. Med. Virol. - 2002. - Vol. 67. - P. 574-582.

[6] Bell M. C, Crowley-Nowick P., Bradlow H.L. et al. Placebo- controlled trial of indol-3-carbinol in the treatment of CIN (cervix cancer)//Gynecol. Oncol. — 2000. - Vol. 78. - P. 123-129.

[7] Bernard H.U., Chan S.-Y., Delius H. Evolution of papillomaviruses// Cur. Top. Microbiol. Immunol. — 1994. - Vol. 186.- P. 33-53.

[8] Bosch F.X., Lorincz A., Munoz N. et al. The causal relation between human papillomavirus and cervical cancer// J. Clin. Pathol. - 2002. - Vol. 55. - P. 244-265.

[9] Chaouki N., Bosch F.X., Munoz N. et al. The viral origin of cervical cancer in Rabat, Morocco// Int. J. Cancer. — 1998. - Vol. 75. - P. 546-554.

[10] Cuschieri K.S., Cubie H.A., Whitley M.W. et al. Multiple high risk HPV infections are common in cervical neoplasia and young women in a cervical screening population//J. Clin. Pathol. — 2004. - Vol. 57. - P. 68-72.

[11] Cuzick J., Terry G., Ho L. et al. Type-specific human papillomavirus DNA in abnormal smears as a predictor of high-grade cervical intraepithelial neoplasia// Br. J. Cancer. - 1994. - Vol. 69. - P. 167-171.

[12] Dalstein V., Riethmuller D., Pretet J.L. et al. Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions: a longitudinal French cohort study// Int. J. Cancer. - 2003. - Vol. 106. - P. 396-403.

[13] Dong S. M., Kim H.S., Rha S.H., Sidransky D. Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix// Clin. Cancer Reseach.- 2001. - Vol. 7. - P. 1982-1986.

[14] Fife K.H., Cramer H.M., Schroeder J.M., Brown D.R. Detection of multiple human papillomavirus types in the lower genital tract correlates with cervical dysplasia// J. Med. Virol. - 2001. - Vol. 64. - P. 550-559.

[15] Franco E., Villa L.L., Rahal P., Ruiz A. Molecular variant analysis as an epidemiological tool to study persistence of cervical human papillomavirus infection//J. Nation. Cancer Inst. - 1994. - Vol. 86. - P. 1558-1559.

[16] Gallo G., Bibbo M., Bagella L. et al. Study of viral integration of HPV-16 in young patients with LSIL//J. Clin. Pathol. - 2003. - Vol. 56. - P. 532-536.

[17] Heinzel Р.А., Chan S.-Y., Ho L. et al. Variation of human papillomavirus type 6 (HPV-6) and HPV-11 genome samples throughout the world//J. Clin. Microbiol. - 1995. - Vol. 33. - P. 1746-1754.

[18] Hernandez-Hernandez D.M., Ornelas-Bernal L., Guido-Jimenez M. et al. Association between high-risk human papillomavirus DNA load and precursor lesions of cervical cancer in Mexican women// Gynecol. Oncol. - 2003. - Vol. 90. - P. 310-317.

[19] Ho L., Chan S.-Y., Burk R. D. et al. The genetic drift of human papillomavirus type 16 is a means of reconstructing prehistoric viral spread and the movement of ancient human populations//J. Virol. - 1993. - Vol. 67. - P. 6413-6423.

[20] Jeon S., Lambert P. Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis//Proc. Natl. Acad. Sci. USA. — 1995. - Vol. 92. - P. 1654-1659.

[21] Junes K.S., Sichero L., Mello W. et al. Intratypic variability of HPV-16 and -18 in tumour biopsies from a high risk area for cervical cancer// 18th International Papillomavirus Conference. - 2000, 23-28 July. - Barcelona, Spain.

[22] Klaes R., Woerner S.M., Ridder R. et al. Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes//Cancer Research-1999. - Vol. 59. - P. 6132-6136.

[23] Lee S.A., Kang D., Seo S.S. et al. Multiple HPV infection in cervical cancer screened by HPVDNA Chip//Cancer Lett. - Vol. 198. - 187-192.

[24] Londesborough P., Ho L., Terry G. et al. Human papillomavirus genotype as a predictor of persistence and development of high-grade lesions in women with minor cervical abnormalities//Int. J. Cancer. - 1996. - Vol. 69. - P. 364-368.

[25] Mansell M.E., Ho L., Terry G. et al. Semi-quantitative human papillomavirus DNA detection in the management of women with minor cytological abnormality//Br. J. Obstet. Gynaecol. - 1994. - Vol. 101. - P. 807-809.

[26] Mazurenko N.. Attaleb M., Gritsko T. et al. High reso-lution mapping of chromosome 6 deletions in cervical cancer//Oncol. Reports. - 1999. - Vol. 6. - P. 859-863.

[27] Munoz N.. Bosch F.X., Sanjose S. et al. Epidemiological classification of human papillomavirus types associated with cervical cancer//New Eng. J. Med. - 2003. - Vol. 348. - P. 518-527.

[28] Ong C.K., Chan S.-Y., Campo M.S. et al. Evolution of human papillomavirus type 18: an ancient phylogenetic root in Africa and intratype diversity reflect co-evolution with human ethnic groups//J. Virol. - 1993. - Vol. 67. - P. 6424-6431.

[29] Ostor A.G. Natural history of cervical intraepithelial neoplasia - a critical review//Int. J. Gynecol. Pathol. - 1993. - Vol. 12. - P. 186-192.

[30] Peitsaro P., Johansson B., Syrjanen S. Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique//J. Clin. Microbiol. - 2002. - Vol. 40. - P. 886-891.

[31] Perovic M. V., Berisavac M.J., Kuljic-Kapulica N., Jovanovic T. High-risk human papillomavirus (HPV) types in patients with squamous intraepithelial lesions (SIL)//Eur. J. Gynaecol. Oncol. - 2003. - Vol. 24. - P. 178-180.

[32] Pirami L., Giache V., Becciolini A. Analysis of HPV16,18, 31, and 35 DNA in pre-invasive and invasive lesions of the uterine cervix//J. Clin. Pathol. — 1997. - Vol. 50. - P. 600-604.

[33] Rha S.H., Dong S.M., Jen J. et al. Molecular detection of cervical intraepithelial neoplasia and cervical carcinoma by microsatellite analysis of Papa-nicolaou smears//Int. J. Cancer. - 2001. - Vol. 93. - P. 424.

[34] Rolon P.A., Smith J.S., Munoz N. et al. Human papillomavirus infection and invasive cervical cancer in Paraguay//Int. J. Cancer. - 2000. - Vol. 85. - P. 486-491.

[35] Rousseau M.C., Abrahamowicz M., Villa L.L. et al. Predictors of cervical coinfection with multiple human papillomavirus types//Cancer Epidemiol. Biomarkers Prev. - 2003. - Vol. 12. - P. 1029-1037.

[36] Samoylova E. V., Shaikhaiev G. O., Petrov S. V. et al. HPV infection in cervical-cancer cases in Russia//Int. J. Cancer. - 1995. - Vol. 61. - P. 337-341.

[37] Song Y. S., Kee S. H., Kim J. W. et al. Major sequence variants in E7 gene of human papillomavirus type 16 from cervical cancerous and non-cancerous lesions of Korean women//Gynaecol. Oncol. - 1997. - Vol. 66. - P. 275-281.

[38] Storey A., Thomas M., Kalita A. et al. Role of a p53 polymorphism in the development of human papillomavirus- associated cancer//Nature-1998. - Vol. 393. - P. 229-234.

[39] Swan D.C., Tucker R.A., Tortolero-Luna G. et al. Human papillomavirus (HPV) DNA copy number is dependent on grade of cervical disease and HPV type//J. Clin.Microbiol. - 1999. - Vol. 37. - P. 1030-1034.

[40] Syrjanen K.J. Biological behavior of cervical intraepithelial neoplasia// New developments in cervical cancer screening and prevention. - Oxford: Blackwell Science, 1997. - P. 93-108.

[41] Szoke K., Sapy T., Krasznai Z. et al. Moderate variation of the oncogenic potential among high-risk human papillomavirus types in gynecologic patients with cervical abnormalities//J. Med. Virol. — 2003. — Vol. 71. — P. 585_592.

[42] Thomas K.K., Hughes J. P., Kuypers J.M. et al. Concurrent and sequential acquisition of different genital human papillomavirus types//J. Infect. Dis. - 2000. — Vol. 182. - P. 1097-1102.

[43] Villa L.L., Sichero L., Rahal P. et al. Molecular variants of human papillomavirus types 16 and 18 preferentially associated with cervical neoplasia//J. Gen. Virol. - 2000. — Vol. 81. - P. 2959-2968.

[44] Vernon S.D., Unger E.R., Miller D.L. et al. Association of human papillomavirus type 16 integration in the E2 gene with poor disease-free survival from cervical cancer//Int. J. Cancer. - 1997. - Vol. 74. - P. 50-56.

[45] Xi L.F., Demers W., Koutsky L.A. et al. Analysis of human papillomavirus type 16 variants indicates establishment

[46] of persistent infection//J. Infect. Dis. - 1995. - Vol. 172. - P. 747-755.

[47] Xi L.F., Koutsky L.A., Galloway D.A. et al. Genomic variation of human papillomavirus type 16 and risk for high-grade cervical intraepithelial neoplasia//J. Nation. Cancer Inst. - 1997. - Vol. 89. - P. 796-802.

[48] Yamada T., Wheeler C.M., Halpern A.L. et al. Human papillomavirus type 16 lineages in the United States populations characterized by nucleotide sequence analysis of the E6, L2 and L1 coding segments//J. Virol. — 1995. — Vol. 69. - P. 7743 -7753.

[49] Zehbe I., Tommasino M. The biological significance of human papillomavirus type 16 variants for the development

[50] of cervical neoplasia// Papillomavirus Report. — 1999. — Vol. 10. - P. 105-116.

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