Evaluation of the effectiveness of the use of the drug epigen in the complex treatment of cervical ectopia associated with papillomavirus infection

Abstract

A comparative analysis of the results of treatment of 242 patients with cervical ectopia associated with human papillomavirus was carried out. It was found that the use of an epigen-intim spray before and after cryodestruction or laser coagulation of the cervix shortens the period of epithelialization and reduces the frequency of recurrence of papillomavirus infection.

Keywords

ectopia of the cervix / human papillomavirus / epigenes / epigen preparation

References

[1] Прилепская В.Н. (ред.) Заболевания шейки матки, влагалища и вульвы. — М.: МЕД-пресс. - 2000. — 432 с.

[2] Русакевич П.С. Заболевания шейки матки. — Минск: Вышейшая школа. - 2000. - 368 с.

[3] Справочник Видаль. Лекарственные препараты в России. - М.: АстраФармСервис. — 2003. - 1520 с.

[4] Шаймарданова Г.И., Савичева А.М., Максимов С.Я. Клинические проявления папилломавирусной инфекции гениталий у женщин//Акушерство и женские болезни. —2001- № 2. - С. 14-19.

[5] Bodner К., Bodner-Adler В., Wierrani F. et al. Is therapeutic conization sufficient to eliminate a high-risk HPV infection of the uterine cervix? A clinicopathological analysis//Anticancer Res. 2002. - Vol. 22, N. 6B. - P. 3733-3736.

[6] Crance J.M., Scaramozzino N., Jouan A., Garin D. Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses //Antiviral Res. - 2003. - Vol. 58, N. 1. - P. 73-79.

[7] Hopman A.H., Smedts F., Dignef W. et al. Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities//J. Pathol. - 2004. - Vol. 202, N 1. - P. 23-33.

[8] Ivanov S., Khadzhiolov N., Ivanov S. [Human papilloma virus (HPV) infection and its relationship with central intraepithelial neoplasia (ClN)]//Akush. Ginekol. (Sofiia). -2001- Vol. 41, N. 2. - P. 34-35.

[9] Kai K., Komine K., Asai K. et al. Anti-inflammatory effects of intramammary infusions of glycyrrhizin in lactating cows with mastitis caused by coagulase-negative staphylococci//Am J. Vet. Res. - 2003. - Vol. 64, N. 10. -P. 1213-1220.

[10] Kucera E., Sliutz G., Czerwenka K. et al. Is high-risk human papillomavirus infection associated with cervical intraepithelial neoplasia eliminated after conization by large- loop excision of the transformation zone?//Eur. J. Obstet. Gynecol. Reprod. Biol. - 2001. - Vol. 100, N. 1. - P. 72-76.

[11] Kumada H. Long-term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C (SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma//Oncology. - 2002. - Vol. 62. - Suppl 1. - P. 94-100.

[12] Lin J.C. Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus rep-lication in vitro//Antiviral Res. - 2003. - Vol. 59, N. 1. - P. 41-47.

[13] Nagai Y., Maehama T., Asato T., Kanazawa K. Persistence of human papillomavirus in-fection after therapeutic conization for GIN 3: is it an alarm for disease recurrence?// Gynecol. Oncol. - 2000. - Vol. 79, N 2. - P. 294-299.

[14] Negri G., Gampenrieder J., Vigl E.E. et al. Human papilloma virus typing at large loop excision of the transformation zone of the cervix uteri//Anticancer Res. —2003- Vol. 23, N 5b. - P. 4289-4292.

[15] Paraskevaidis E., Koliopoulos G., Atamanos Y. et al. Human papillomavirus testing and the outcome of treatment for cervical intraepithelial neoplasia//Obstet. Gynecol. — 2001. - Vol. 98, N 5. - Pt. 1. - P. 724-725.

[16] Raphael T.J., Kuttan G. Effect of naturally occurring triterpenoids glycyrrhizic acid, ur-solic acid, oleanolic acid and nomilin on the immune system//Phytomedicine. -2003- Vol. 10, N 6-7. - P. 483-489.

[17] Southern S.A., Graham D.A., Herrington C.S. Discrimination of human papillomavirus types in low and high grade cervical squamous neoplasia by in situ hybridization.//Diagn. Mol. Pathol. - 1998. - Vol. 7, N 2. - P. 114-121.

RIGHTS & PERMISSIONS

Eсо-Vector