Oxidiring updating of protein and endogenic intoxication as parameters of weight EPH-gestosis

Abstract

Is investigated contents of substances low and average molecular of weight (SLAMW) in plasma of blood, in erythrocytes and urine, and process of oxidizing updating serum s proteins of blood at 11 unpregnant women, at 22 pregnant women with physiological current of pregnancy, at 9 pregnant of risk’s group on development EPH-gestosis and at 33 pregnant, suffering by EPH-gestosis. On the basis of received facts following conclusions were made. Processes of agrégation of proteins prevail at physiological current of pregnancy. Endogenic intoxication at healthy pregnant not observed. In connection with an increase of concentration the active forms of an oxygen in a body of pregnant from risk’s group, process of agrégation of protein considerably more intensive. We can observe among the pregnant of risk’s group the first “compensatory” phase of endogenic intoxication, which accompanied by increase SLAMW in erythrocytes. The oxidizing updating of protein amplifies in a greater degree at pregnant women suffering by EPH- gestosis. Is observed as agrégation of protein’s molecules, as its destruction.

Keywords

low and medium molecular weight substances / oxidative modification of proteins / protein aggregation / gestosis

References

[1] Беднарский А.С., Чайка Н.А., Ярославский В.К., Данилова Л.А., Резников Л.Л. //Акуш. и тин. - 1995. -№1. - С. 18-22.

[2] Ветров В.В., Леваневич В.В. // Акуш. и гин. - 1990. - №6. - С. 50- 54.

[3] Зильбер А.П., Шифман Е.М., Павлов А.Г. // Преэклапсия и эклампсия: клинико- физиологические основы и алгоритмы диагностики. - Петрозаводск, 1997. - С. 9.

[4] Кацулов Ат. //Акуш. и гин. - 1990. -№10. - С. 6-8.

[5] Малахова М.Я. //Метод регистрации эндогенной интоксикации.- СПб., 1995.

[6] Репина М.А. //Ошибки в акушерской практике.-Л., 1988, С. 55.

[7] Davies К. J.A., LinS.W., Pacifici Р.Е. //J.Biol.Chem.,1987.- V.262, Р. 9914

[8] Freidman S.A., Taylor P.N., Roberts J.M. Patophysiology ofpre-eclampsia and hypertension and pregnancy // Clinics in Perinatology, 1991, V. 18, P. 661-682.

[9] Oliver С. N., Ahn B. W., Moreman E.J., Goldshtein S., Stadman E.P. // J.Biol.Chem. ,1987,V.262.,P.5488.

[10] Richards D. C. H., Dean R. T., Jessup И/. //Biochim. et biophys. acta, 1988, V.946, P.281.

[11] Sibai B.M.// Amer.J. Obstet. Gynecol., 1990, V. 163, P. 1049-1055.

[12] Wolf S.P, Dean R.T., Garner A.// Trends Biochim. Sei., 1986, V. 11, P. 27.

RIGHTS & PERMISSIONS

Eсо-Vector