Osteoprotegerin and its ligands for regulating the osteal resorption: experimental and clinical application aspects under estrogen deficiency conditions

S. V. Yureneva

Journal of obstetrics and women's diseases ›› 2004, Vol. 53 ›› Issue (1) : 107 -110.

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Journal of obstetrics and women's diseases ›› 2004, Vol. 53 ›› Issue (1) : 107 -110. DOI: 10.17816/JOWD87168
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Osteoprotegerin and its ligands for regulating the osteal resorption: experimental and clinical application aspects under estrogen deficiency conditions

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Abstract

Modem conceptions concerning the role of OPG-RANK-RANKL system in a local paracrinic mechanism of the regulation of osteoclastogenesis and osteal resorption processes are presented in this article. Here, results of the first clinical researches of prognostic signification of ORG determinations for estimating disruption manifestations in osteal metabolism under estrogen deficiency conditions as well as data on the OPG use as an anti-resorbable agent at the treatment of post-menopausal osteoporosis.

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severe deficiency states / osteoprotegerin / disorders in bone metabolism / postmenopausal osteoporosis

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S. V. Yureneva. Osteoprotegerin and its ligands for regulating the osteal resorption: experimental and clinical application aspects under estrogen deficiency conditions. Journal of obstetrics and women's diseases, 2004, 53(1): 107-110 DOI:10.17816/JOWD87168

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