Reproduction immunology: old dogmas and new conceptions

О. V. Pavlov , S. A. Selkov

Journal of obstetrics and women's diseases ›› 2004, Vol. 53 ›› Issue (1) : 89 -97.

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Journal of obstetrics and women's diseases ›› 2004, Vol. 53 ›› Issue (1) : 89 -97. DOI: 10.17816/JOWD87157
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Reproduction immunology: old dogmas and new conceptions

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Abstract

The article reviews the recent data concerning the role, which components of immune system play in the regulation of gestation. The evidences are provided for the participation of cytokines and immune cells in pathogenesis of pre-eclampsia and spontaneous abortion. The attempt has been made to demonstrate the evolution of ideas and conceptions in this field for past 10-15 years.

Keywords

pregnancy / labor / spontaneous abortion / preeclampsia / uteroplacental complex / cytokines / immune cells

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О. V. Pavlov, S. A. Selkov. Reproduction immunology: old dogmas and new conceptions. Journal of obstetrics and women's diseases, 2004, 53(1): 89-97 DOI:10.17816/JOWD87157

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References

[1]

Павлов О.В, Сельков С.А., Селютин С.А., Ананьева В.В. Секреция фактора некроза опухоли-α и интерлейкина-1 плацентарными макрофагами in vitro при различных исходах беременности//Бюлл. экспер. биол. и мед.— 1999.— № 7.— С. 97-100.

[2]

Ширшев С.В. Механизмы иммунного контроля процессов репродукции.— Екатеринбург, 1999.— 383 с.

[3]

Benian A., Madazli R., Aksu Е., Uzun H., Aydin S. Plasma and placental levels of interleukin-10, transforming growth factor-beta1, and epithelial-cadherin in preeclampsia//Obstet. Gynecol.- 2002.- Vol. 100.- P. 327-331.

[4]

Bennett W.A., Lagoo-Deenadayalan S., Whitworth N.S., et al. First-trimester human chorionic villi express both immunoregulatory and inflammatory cytokines: a role for interleukin-10 in regulating the cytokine network of pregnancy//Am. J. Reprod. Immunol.— 1999.— Vol. 41.— P. 70—78.

[5]

Benyo D.F., Miles T.M., Conrad K.P. Hypoxia stimulates cytokine production by villous explants from the human placenta//J. Clin. Endocrinol. Metab.— 1997.— Vol. 82.- P. 1582-1588.

[6]

Bulmer J.N. Immune cells in decidua //Immunology of Human Reproduction 251/ M.Kurpitz, N.Fernandez, eds.— BIOS Scientific Publishers, Oxford, 1995.— P. 313—334.

[7]

Burk M. R., Troeger C., Brinkhaus R. et al. Severely reduced presence of tissue macrophages in the basal plate of pre-eclamptic placentae//Placenta.— 2001.— Vol. 22,- P. 309-316.

[8]

Cervar M., Blaschitz A., Dohr G., Desoye G. Paracrine regulation of distinct trophoblast functions in vitro by placental macrophages//Cell. Tissue Res.— 1999.— Vol. 295.- P. 297-305.

[9]

Chaouat G., Zourbas S., Ostojic S., et al. A brief review of recent data on some cytokine expressions at the maternofoetal interface which might challenge the classical Th1/Th2 dichotomy //J. Reprod. Immunol.— 2002.— Vol. 53.- P. 241-256.

[10]

Chaouat G. Innately moving away from the Th1/Th2 paradigm in pregnancy//Clin. Exp. Immunol.— 2003.— Vol. 131.- P. 393-395.

[11]

Conrad K.P., Miles T.M., Benyo D.F. Circulating levels of immunoreactive cytokines in women with preeclampsia//Am. J. Reprod. Immunol.— 1998.— Vol. 40.— P.102-111.

[12]

Ekerfelt C., Lidstrom C., Matthiesen L., et al. Spontaneous secretion of interleukin-4, interleukin-10 and interferongamma by first trimester decidual mononuclear cells//Am. J. Reprod. Immunol.— 2002.— Vol. 47.— P. 159-166.

[13]

Fallon P.G., Jolin H.E., Smith P. et al. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9 and IL-13//Immunity.— 2002 — Vol. 17.- P. 7-17.

[14]

Guilbert L., Robertson S.A., Wegmann T.G. The trophoblast as an integral component of a macrophagecytokine network//Immunol. Cell. Biol.— 1993.— Vol. 71.- P. 49-57.

[15]

Guleria I., Pollard J. W. The trophoblast is a component of the innate immune system during pregnancy//Nat. Med.— 2000.— Vol. 6.- P. 589-593.

[16]

Hayakawa S., Fujikawa T., Fukuoka H., et al. Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation//J. Reprod. Immunol.— 2000.- Vol. 47.— P. 121-138.

[17]

Hunt J.S. Cytokine networks in the uteroplacental unit: macrophages as pivotal regulatory cells//J. Reprod. Immunol.— 1989.— Vol. 16.— P. 1-17.

[18]

Каuта S.W., Wang Y., Walsh S.W. Preeclampsia is associated with decreased placental interleukin-6 production//J. Soc. Gynecol. Invest.— 1995.— Vol. 2.— P. 614-617.

[19]

Khan S., Katabuchi H., Araki M. et al. Villous macro- phage-conditioned media enhance human trophoblast growth and differentiation in vitro//Biol. Reprod.— 2000 - Vol. 62.- P. 1075-1083.

[20]

Kwak-Kim J. Y., Chung-Bang H.S., Ng S.C. et al. Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF//Hum. Reprod.— 2003 — Vol. 18.— P. 767-773.

[21]

Laham N., Rice G.E., Bishop G.J., Ransome C., Brennecke S.P. Interleukin-8 concentrations in amniotic fluid and peripheral venous plasma during human pregnancy and parturition//Acta Endocrinol.— 1993.— Vol. 129.— P. 220-224.

[22]

Laham N., Brennecke S.P., Bendtzen K., Rice G.E. Tumour necrosis factor alpha during human pregnancy and labour: maternal plasma and amniotic fluid concentrations and release from intrauterine tissues//Eur. J. Endocrinol.- 1994.- Vol. 131.- P. 607-614.

[23]

Laham N., Brennecke S.P., Bendtzen K., Rice G.E. Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment//J. Endocrinol.— 1996.— Vol. 149.— P. 431-439.

[24]

Laham N., Brennecke S.P., Bendtzen K, Rice G.E. Labour-associated increase in interleukin-1 alpha release in vitro by human gestational tissues//J. Endocrinol- Vol. 150.- P. 515-522.

[25]

Laham N., Brennecke S.P., Rice G.E. Interleukin-8 release from human gestational tissue explants: the effects of lipopolysaccharide and cytokines//Biol. Reprod.— Vol. 57.- P. 616-620.

[26]

Makhseed М., Raghupathy R., Azizieh F. et al. Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions//Hum. Reprod.— 2001.— Vol. 16.— P. 2219-2226.

[27]

Malek A., Sager R., Schneider H. Effect of hypoxia, oxidative stress and lipopolysaccharides on the release of prostaglandins and cytokines from human term placental explants//Placenta.— 2001.— Vol. 22.— P. 545-550.

[28]

Matsubara S., Takayama T., Yamada T. et al. Hofbauer cell activation and its increased glucose-6-phosphate dehydrogenase activity in second trimester-spontaneous abortion: an ultrastructural dual staining enzyme- cytochemical study//Am. J. Reprod. Immunol.— 2003.— Vol. 49 - P. 202-209.

[29]

Mitchell M.D., Edwin S.S., Romero R. Prostaglandin biosynthesis by human decidual cells: effects of inflammatory mediators//Prostaglandins Leukot. Essent. Fatty Acids.- 1990.- Vol. 41.- P. 35-38.

[30]

Norwitz E.R., Starkey P.M., Lopez A. et al. Identification by flow cytometry of the prostaglandin-producing cell populations of term human decidua.// J. Endocrinol.— Vol. 131.- P. 327-334.

[31]

Piccinni M.P., Beloni L., Livi C. et al. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions//Nat. Med.— 1998.— Vol. 4.— P. 1020-1024.

[32]

Rein D.T., Schondorf T., Gohring U.J. et al. Cytokine expression in peripheral blood lymphocytes indicates a switch to T(helper) cells in patients with preeclampsia//J. Reprod. Immunol.— 2002.— N 54.— P. 133-142.

[33]

Rein D.T., Breidenbach M., Honscheid B. et al. Preeclamptic women are deficient of interleukin-10 as assessed by cytokine release of trophoblast cells in vitro//Cytokine.— 2003.— Vol. 23.— P. 119-125.

[34]

Reister F., Frank H.-G., Heyl W. et al. The distribution of macrophages in spiral arteries of the placental bed in pre-eclampsia differs from that in healthy patients//Placenta.— 1999.— Vol. 20.— P. 229-233.

[35]

Reister E, Frank H.-G., John C. et al. Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women//Lab. Invest.— 2001.— Vol. 81.— P. 1143—1152. Rinehart ВК., Terrone D.A., Lagoo-Deenadayalan S. et al. Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia//Am. J. Obstet. Gynecol.— 1999.— Vol. 181.- P. 915-920.

[36]

Romero R.L., Mazor M. Infection and preterm labor//Clin. Obstet. Gynecol.- 1988.- Vol. 31.- P. 553-559.

[37]

Romero R.L., Avila C., Santhanam U., Sehgal P.B.//Amniotic fluid interleukin 6 in preterm labor. Association with infection//J. Clin. Invest.— 1990.— Vol. 85.— P. 1392-1399.

[38]

Sacks G.P., Redman C.W.G., Sargent I.L. Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells//Clin. Exp. Immunol.— 2003.— Vol. 131.— P. 490-497.

[39]

Sato T.A., Keelan J.A., Mitchell M.D. Critical paracrine interactions between TNF-alpha and IL-10 regulate lipopolysaccharide-stimulated human choriodecidual cytokine and prostaglandin E2 production//J. Immunol.— 2003.— Vol. 170.— P. 158—166.

[40]

Steinbom A., Kuhnert M., Halberstadt E. Immunmodulating cytokines induce term and preterm parturition//J. Perinat.Med.— 1996.— Vol. 24.— P. 381—390.

[41]

Steinhorn A., Gunes H., Roddiger S., Halberstadt E. Elevated placental cytokine release, a process associated with preterm labor in the absence of intrauterine infection//Obstet. Gynecol.— 1996.— Vol. 88.— P. 534-539.

[42]

Steinborn A., von Gall C., Hindelbrand R. et al. Identification of placental cytokine-producing cells in term and preterm labor//Obstet. Gynecol.— 1998— Vol. 91- P. 329-335.

[43]

Steinborn A., Sohn C., Sayehli C. et al. Preeclampsia, a pregnancy-specific disease, is associated with fetal monocyte activation//Clin. Immunol.— 2001.— Vol. 100- P. 305-313.

[44]

Vince G.S., Johnson P.M. Leucocyte populations and cytokine regulation in human uteroplacental tissue//Biochem. Soc. Trans.— 2000.— Vol. 28.— P. 191—195.

[45]

Vuckovic M., Genbacev O., Kumar S. Immunohistochemical localisation of transforming growth factor-beta in first and third trimester human placenta// Pathobiology.— Vol. 60.- P. 149-150.

[46]

Wegmann T.G., Lin H., Guilbert L., Mosmann T.R. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon?//Immunol. Today.— 1993.— Vol. 14.— P. 353-356.

[47]

Wetzka B., Clark D.E., Charnock-Jones D.S. et al. Isolation of macrophages (Hofbauer cells) from human term placenta and their prostaglandin E2 and thromboxane production.//Hum. Reprod.— 1997.— Vol. 12.— P. 847-885.

[48]

Wilczynski J.R., Tchorzewski H., Banasik M. et al. Lymphocyte subset distribution and cytokine secretion in third trimester decidua in normal pregnancy and preeclampsia//Eur. J. Obstet. Gynecol. Reprod. Biol.— 2003.— Vol. 109 — P. 8-15.

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