Hemostasis system and immunomorphologic state of placenta under presence of antiphospholipid antibodies in plasma with consideration of their class and pregnancy outcome

N. G. Kosheleva; L. В. Zubzhitskaia; О. N. Arzhanova; О. V. Tyshkevich; Y. Gromyko; Т. N. Shlyakhtenko; Т. A. Pluzhnikova; Е. А. Shapovalova

doi:10.17816/JOWD86971

Journal of obstetrics and women's diseases ›› 2004, Vol. 53 ›› Issue (1) : 22 -26. DOI: 10.17816/JOWD86971

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Hemostasis system and immunomorphologic state of placenta under presence of antiphospholipid antibodies in plasma with consideration of their class and pregnancy outcome

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Abstract

The present study was undertaken to investigate hemostasis system of 197 women with recurrent miscarriage: Analysis placentas by immunomorphology are studied of 41 women and of 52 women with autoimmune antibodies to β₂-glycoprotein-I (β₂-GPI) in placenta. There was exposed hyperactivation platelets blood of all women with antiphospholipid antibodies irrespective of groups with significantly was increased at the beginning of pregnancy and progressed with growing gestation. As result of investigation it is determined certain connection between outcome of pregnancy and activation degree platelets blood in vasculars. Was found absence influence anticardiolipin antibodies (aCL) on plasmocoagulative link hemostasis. The circulation of lupus anticoagulant (LA) was accompanied indication of hypercoagulation. In all research groups was determined significant oppression of fibrinolisis. Analysis placentas by immunomorphology was determined significantly tissue damages with LA and β₂-GPI-dependent aCL.

Keywords

hemostasis / immunomorphology / antibodies / antiphospholipid / hypercoagulation

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N. G. Kosheleva, L. В. Zubzhitskaia, О. N. Arzhanova, О. V. Tyshkevich, Y. Gromyko, Т. N. Shlyakhtenko, Т. A. Pluzhnikova, Е. А. Shapovalova. Hemostasis system and immunomorphologic state of placenta under presence of antiphospholipid antibodies in plasma with consideration of their class and pregnancy outcome. Journal of obstetrics and women's diseases, 2004, 53(1): 22-26 DOI:10.17816/JOWD86971

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