Comparative estimation of life quality in women of early postmenopausal period depending on level of mdbt after menopausae developed in the natural way and as a result of ovarioectomia

Abstract

Last years the attention of researchers is involved in studying of role of calcic homeostasis infringements in development of not only bone rarefication, but also osteoartrosis, arteriosclerosis, arterial hypertension, demention. Mentioned diseases, alongside with a bone rarefication, are the most frequently occured in persons of advanced age. The given pathology is offered for defining(determining) as «estrogen- deficiency diseases», «calcium-scarce»diseases. The definition of pathogenetic interrelation between metabolic infringements in postmenopause and the various somatic pathology arising during the given period of time still remains one of the actual problems. The purpose of the present research was studying frequency of occurrence, a degree of expressiveness of climacteric symptoms and extragenital diseases depending on level of MDBT at women with identical duration of estrogen deficiency conditions after the introduction in natural and surgical menopause. 120 women in the age of44-54 years old (mean age 52,5±0,4 y.o.) were examined and included in the 1st group of study, the Ilnd group consisted of 80 women after ovarioectomy in the age of 38-52 y.o. (mean age 46,2±2,3 y.o.). There were revealed that life quality of women who had entered in postmenopause after ovarioectomy was worse in comparison with life quality of women in natural postmenopause. The certain interrelation between degree of some climacteric symptoms expressiveness, intensity of painful syndrome in osteo-muscular system, prevalence of extragenitaldiseases and level of MDBT was revealed.

Keywords

postmenopause / ovarioectomy / calcium-scarce illnesses / life quality

References

[1] Зазерская И.Е., Кузнецова Л.В., Дячук А.В. и др. Особенности костного обмена у женщин репродуктивного возраста после билатеральной овариоэктомии//Ж. акуш. жен. болезн. - 2005. - Т. LIV, Вып. 3. - С. 28-37.

[2] Кулаков В.И., Сметник В.П., Краснов В.Н. и др. Аффективные расстройства после овариоэктомии, психосоматические и терапевтические аспекты//Ж. акуш. жен. болезн. — 1999. - Т. XLVIII, Вып. 4. - С. 2-30.

[3] Маличенко С.Б. Особенности клинического течения сердечно-сосудистых заболеваний при постменопаузальном остеопорозе. Возможности применения фемостона при поздних осложнениях климактерия//Остеопороз и остеопатии. - 2000. - № 2. - С. 27-32.

[4] Маличенко С.Б. Принципы диагностики, профилактики и фармакотерапии постменопаузального симптомокомплекса//Клинич. геронтология и гериатрия. — 1999, — № 1. - С. 60-70.

[5] Насонов Е.Л. Остеопороз и заболевания сердечно-сосудистой системы//Кардиология. - 2002. - № 3. - С. 80-82.

[6] Насонов ЕЛ., Самсонов М.Ю. Новые направления исследования воспаления при ревматических заболеваниях//Избранные лекции по клинической ревматологии / Под. ред. В.А. Насоновой и Н.В. Бунчука. — М.: Медицина. — 2001 — 270 с.

[7] Руководство по остеопорозу / Под. ред. Л.И. Беневоленской//М.: БИНОМ. - 2003. - С. 346-363.

[8] Юренева С.В., Сметник В.П., Любимова Н.В., Абаев В.М. Маркеры костного ремоделирования у пациенток с хирургической менопаузой при заместительной гормональной терапии препаратом дивигель//Вестник Росс. Ассоц. Акуш.-гинек. — 2001. - № 2. — С. 55_59

[9] Юренева С.В., Сметник В.П. Состояние костной ткани у женщин репродуктивного возраста в различные сроки. После овариоэктомии//Акуш. и гинек. - 1995. - № 3. - С. 41-44.

[10] Browner W.S., Sooley D.G. Non-Trauma mortality in eldery women with low bone mineral density//Lancet. - 1991. - Vol. 338. - P. 335-338.

[11] Browner W.S., Pressman A.R. Association between low density and stroke//1993. - Vol. 24. - P. 940-946.

[12] Dinarello C.A., Moldaver L.L. Proinflammatory and antiinflammatory cytokines in rheumatoid arthritis. A primer for clinicians//Amgen. - 2001. - 300 p.

[13] Europ. Consensus Development Conference on Menopause. Montereux, Switzerland / Eds.: M. H. Birkhauser, H. Rosenbaum, Editions//ESKA. - Paris. - 1995.

[14] Fox D.A. The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives//Arthritis Rheum. - 1997. - Vol. 40. - P. 598-609.

[15] Hofbauer L.C., Heufelder A.E. The role of osteoprotegerin and receptor activator of nuclear factor kB ligand in the pathogenesis and treatment of rheumatoid arthritis//Arthritis Rheum. - 2001. — Vol. 44. - P. 253-259.

[16] O’Brien S., Ismail K.M.K., Jain K. Premenstrual syndrome and the menopause I The Management of the menopause. J.Studd (eds.). //The Parthenon Publishing Group. — 2003. - P. 111-119.

[17] Riggs B.L. et al. Clinical trial of fluoride therapy in postmenopausal osteoporotic woman: extended observations and additional analysis//J. Bone Miner. Res. -1994. - Vol. 9. - P. 265-275.

[18] Von Eiff A.W. The effect of estrogens and progestins on blood pressure regulations of normotensisive women//J. AM Obstet. Gynecol. - 1971. - Vol. 109. - P. 887-892.

[19] WHO Study Group Assesment of fracture risk and its application to screening for postmenopausal osteoporosis//World Health Organization. Technical Report Series. - 1994. - Vol. 843. — 129 p.

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