Dydrogesterone (duphaston) and its 20-dihydro- metabolite as selective modulators of estrogenic enzymes in human breast cancer cells
Н. Н. Thole , G. S. Chetrite , G. S. Philippe , J. R. Pasqualini
Journal of obstetrics and women's diseases ›› 2005, Vol. 54 ›› Issue (2) : 67 -72.
Dydrogesterone (duphaston) and its 20-dihydro- metabolite as selective modulators of estrogenic enzymes in human breast cancer cells
The presented data open up interesting prospects for studying the biological responses of progestogens in clinical trials in patients with breast cancer. Estradiol is one of the main factors that control the growth and development of breast cancer. Therefore, an important goal of research in recent years is to block the formation of estradiol inside cancer cells.
dydrogesterone / progestogens / breast cancer cells / sulfatase / 17 β —hydrosteroid — dehydrogenase
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