Influence gene vdr3 genotypes and alleles on bone turnover in early postmenopausae

I. Е. Zazerskaya; М. V. Aseev; L. V. Kuznetsova; М. V. Moskalenko; Т. Е. Ivashenko; V. S. Baranov

doi:10.17816/JOWD81636

Journal of obstetrics and women's diseases ›› 2005, Vol. 54 ›› Issue (2) : 23 -30. DOI: 10.17816/JOWD81636

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Influence gene vdr3 genotypes and alleles on bone turnover in early postmenopausae

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Abstract

Studies on the genetics have focused on the regulation of bone mineral density (BMD) a major predictor of osteoporotic fracture risk. Evidence for a genetic contribution to BMD regulation comes primarily from twin studies — that’s hawed that between 50—70 % of variance in BMD is caused by genetic factors. A great deal of research has been done on gene candidate VDR.3 on 176 postmenopausal women (108 natural menopause and 69 surgical menopause). Polymorphisms of vitamin D receptor have been associated in our group with the speed of bone turnover, registries by DEXA with interval 12 months and DDR test. The every second patient with genotype tt has chance to accompany group with osteoporosis in postmenopausae. In group of women with highs speed of bone turnover frequency t allel in 3 time more than in group with slow bone turnover.

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gene VDR3 / alleles / genotypes / natural / surgical postmenopausae / bone turnover

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I. Е. Zazerskaya,М. V. Aseev,L. V. Kuznetsova,М. V. Moskalenko,Т. Е. Ivashenko,V. S. Baranov. Influence gene vdr3 genotypes and alleles on bone turnover in early postmenopausae. Journal of obstetrics and women's diseases, 2005, 54(2): 23-30 DOI:10.17816/JOWD81636