Effect of dydrogesterone on the hormonal profile and concentration of progesterone-induced blocking factor in pregnant women with threatened abortion

Jaroslaw Kalinka , Julia Szekeres-Bartho

Journal of obstetrics and women's diseases ›› 2005, Vol. 54 ›› Issue (1) : 96 -102.

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Journal of obstetrics and women's diseases ›› 2005, Vol. 54 ›› Issue (1) : 96 -102. DOI: 10.17816/JOWD81599
Environment and woman reproduction health
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Effect of dydrogesterone on the hormonal profile and concentration of progesterone-induced blocking factor in pregnant women with threatened abortion

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Abstract

Problem: The therapeutic value of progestogens in threatened abortion is still under debate. In the presence of sufficient progesterone levels during pregnancy, lymphocytes synthesize a mediator [progesterone-induced blocking factor (PIBF)] that is anti-abortive in mice. The aim of this study was to evaluate the effect of dydrogesterone on pregnancy outcome of threatened aborters.

Method of study: Twenty-seven threatened aborters were treated for 10 days with dydrogesterone (30-40 mg/day). Sixteen healthy pregnant controls received no treatment. Serum progesterone and estradiol concentrations as well as urine PIBF concentrations were measured by enzyme-linked immunosorbent assay (ELISA).

Results: Pregnancy outcomes in dydrogesterone-treated threatened aborters did not statistically differ from those in healthy controls. Serum progesterone concentrations in control patients, but not those in threatened aborters increased as pregnancy progressed. Following dydrogesterone treatment, initially low PIBF concentrations of threatened aborters significantly increased (P = 0,001) to reach the PIBF level found in healthy controls.

Keywords

dydrogesterone / early pregnancy / progesterone-induced blocking factor / threatening abortion

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Jaroslaw Kalinka, Julia Szekeres-Bartho. Effect of dydrogesterone on the hormonal profile and concentration of progesterone-induced blocking factor in pregnant women with threatened abortion. Journal of obstetrics and women's diseases, 2005, 54(1): 96-102 DOI:10.17816/JOWD81599

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