Modern concepts of etiology, pathogenesis and risk factors for preeclampsia
Maria Yu. Abramova , Mikhail I. Churnosov
Journal of obstetrics and women's diseases ›› 2021, Vol. 70 ›› Issue (5) : 105 -116.
Modern concepts of etiology, pathogenesis and risk factors for preeclampsia
Preeclampsia is a serious complication of pregnancy and complicates its course in 2-8% of all cases. According to the literature, the disease is associated with an increase in maternal and perinatal morbidity and mortality, and is a predictor of the development of chronic diseases in the distant future, which is an important medical and social issue. Of particular interest is the study of the molecular mechanisms of etiopathogenesis and risk factors for preeclampsia, which, unfortunately, are currently poorly studied and understood, thus dictating the need for further study of this complication of pregnancy. This article discusses the current understanding of the etiology, pathogenesis and risk factors for preeclampsia.
preeclampsia / etiology / pathogenesis / risk factors
| [1] |
Reshetnikov EA. rs34845949 polymorphism of the SASH1 gene is associated with the risk of preeclampsia. Research Results in Biomedicine. 2021;7(1):44−55. (In Russ.). DOI: 10.18413/2658-6533-2020-7-1-0-4 |
| [2] |
Решетников Е.А. Полиморфизм rs34845949 гена SASH1 ассоциирован с риском развития преэклампсии // Научные результаты биомедицинских исследований. 2021. Т. 7. Вып. 1. С. 44−55. DOI: 10.18413/2658-6533-2020-7-1-0-4 |
| [3] |
WHO Guidelines Approved by the Guidelines Review Committee. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia. World Health Organization; 2011. [cited 23 Aug 2021]. Available from: https://pubmed.ncbi.nlm.nih.gov/23741776/ |
| [4] |
WHO Guidelines Approved by the Guidelines Review Committee. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia. World Health Organization; 2011. [дата обращения 23.08.2021]. Доступ по ссылке: https://pubmed.ncbi.nlm.nih.gov/23741776/ |
| [5] |
Osnovnye pokazateli zdorov’ja materi i rebenka, dejatel’nost’ sluzhby ohrany detstva i rodovspomozhenija v Rossijskoj Federacii. Statisticheskij sbornik 2018. Moscow; 2019. [cited 23.08.2021]. Available from: https://minzdrav.gov.ru/ministry/61/22/stranitsa-979/statisticheskie-i-informatsionnye-materialy/statisticheskiy-sbornik-2018-god. (In Russ.) |
| [6] |
Основные показатели здоровья матери и ребенка, деятельность службы охраны детства и родовспоможения в Российской Федерации. Статистический сборник 2018. Москва, 2019. [дата обращения 23.08.2021]. Доступ по ссылке: https://minzdrav.gov.ru/ministry/61/22/stranitsa-979/statisticheskie-i-informatsionnye-materialy/statisticheskiy-sbornik-2018-god |
| [7] |
Garovic VD, White WM, Vaughan L, et al. Incidence and long-term outcomes of hypertensive disorders of pregnancy. J Am Coll Cardiol. 2020;75(18):2323−2334. DOI: 10.1016/j.jacc.2020.03.028 |
| [8] |
Garovic V.D., White W.M., Vaughan L. et al. Incidence and long-term outcomes of hypertensive disorders of pregnancy // J. Am. Coll. Cardiol. 2020. Vol. 75. No. 18. P. 2323−2334. DOI: 10.1016/j.jacc.2020.03.028 |
| [9] |
Ivanov II., Cheripk MV, Kosolapova NV, et al. Preeklampsiya beremennyh: osobennosti patogeneza, taktiki vedeniya. Tavricheskij mediko-biologicheskij vestnik. 2012;15(2):273−286. (In Russ.) |
| [10] |
Иванов И.И., Черипко М.В., Косолапова Н.В. и др. Преэклампсия беременных: особенности патогенеза, тактики ведения // Таврический медико-биологический вестник. 2012. Т. 15. № 2. С. 273−286. |
| [11] |
Golovchenko O, Abramova M, Ponomarenko I, et al. Functionally significant polymorphisms of ESR1and PGR and risk of intrauterine growth restriction in population of central Russia. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2020; 253:52−57. DOI: 10.1016/j.ejogrb.2020.07.045 |
| [12] |
Golovchenko O., Abramova M., Ponomarenko I. et al. Functionally significant polymorphisms of ESR1and PGR and risk of intrauterine growth restriction in population of central Russia // European Journal of Obstetrics and Gynecology and Reproductive Biology. 2020. Vol. 253. P. 52−57. DOI: 10.1016/j.ejogrb.2020.07.045 |
| [13] |
Pankiewicz K, Fijałkowska A, Issat T, et al. Insight into the key points of preeclampsia pathophysiology: Uterine artery remodeling and the role of MicroRNAs. Int J Mol Sci. 2021;22(6):3132. DOI: 10.3390/ijms22063132 |
| [14] |
Pankiewicz K., Fijałkowska A., Issat T. et al. Insight into the key points of preeclampsia pathophysiology: Uterine artery remodeling and the role of microRNAs // Int. J. Mol. Sci. 2021. Vol. 22. No. 6. P. 3132. DOI: 10.3390/ijms22063132 |
| [15] |
Hodzhaeva ZS, Holin AM, Vihljaeva EM. Rannjaja i pozdnjaja prejeklampsija: paradigmy patobiologii i klinicheskaja praktika. Obstetrics and Gynecology. 2013;(10):4−11. (In Russ.) |
| [16] |
Ходжаева З.С., Холин А.М., Вихляева Е.М. Ранняя и поздняя преэклампсия: парадигмы патобиологии и клиническая практика // Акушерство и гинекология. 2013. № 10. C. 4−11. |
| [17] |
Ogge G, Chaiworapongsa T, Romero R, et al. Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia. J Perinat Med. 2011;39(6):641−652. DOI: 10.1515/jpm.2011.098 |
| [18] |
Ogge G., Chaiworapongsa T., Romero R. et al. Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia // J. Perinat. Med. 2011. Vol. 39. No. 6. P. 641−652. DOI: 10.1515/jpm.2011.098 |
| [19] |
Ajlamazjan JeK, Stepanova OI, Sel’kov SA, Sokolov DI. Kletki immunnoj sistemy materi i kletki trofoblasta: “Konstruktivnoe sotrudnichestvo” radi dostizhenija sovmestnoj celi. Vestnik Rossijskoj akademii medicinskih nauk. 2013;68(11):12−21. (In Russ.) |
| [20] |
Айламазян Э.К., Степанова О.И., Сельков С.А., Соколов Д.И. Клетки иммунной системы матери и клетки трофобласта: «Конструктивное сотрудничество» ради достижения совместной цели // Вестник РАМН. 2013. Т. 68. № 11. С. 12−21. |
| [21] |
Moser G, Windsperger K, Pollheimer J, et al. Human trophoblast invasion: new and unexpected routes and functions. Histochem Cell Biol. 2018;150(4):361−370. DOI: 10.1007/s00418-018-1699-0 |
| [22] |
Moser G., Windsperger K., Pollheimer J. et al. Human trophoblast invasion: new and unexpected routes and functions // Histochem. Cell Biol. 2018. Vol. 150. No. 4. P. 361−370. DOI: 10.1007/s00418-018-1699-0 |
| [23] |
Highet AR, Khoda SM, Buckberry S, et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion. Eur J Cell Biol. 2015;94(12):589−602. DOI: 10.1016/j.ejcb.2015.10.004 |
| [24] |
Highet A.R., Khoda S.M., Buckberry S. et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion // Eur. J. Cell Biol. 2015. Vol. 94. No. 12. P. 589−602. DOI: 10.1016/j.ejcb.2015.10.004 |
| [25] |
Prossler J, Chen Q, Chamley L, James JL. The relationship between TGF, low oxygen and the outgrowth of extravillous trophoblasts from anchoring villi during the first trimester of pregnancy. Cytokine. 2014;68(1):9−15. DOI: 10.1016/j.cyto.2014.03.001 |
| [26] |
Prossler J., Chen Q., Chamley L., James J.L. The relationship between TGF, low oxygen and the outgrowth of extravillous trophoblasts from anchoring villi during the first trimester of pregnancy // Cytokine. 2014. Vol. 68. No. 1. P. 9−15. DOI: 10.1016/j.cyto.2014.03.001 |
| [27] |
Albers RE, Kaufman MR, Natale BV, et al. Trophoblast-specific expression of hif-1 results in preeclampsia-like symptoms and fetal growth restriction. Sci Rep. 2019;9(1):2742. DOI: 10.1038/s41598-019-39426-5 |
| [28] |
Albers R.E., Kaufman M.R., Natale B.V. et al. Trophoblast-specific expression of hif-1 results in preeclampsia-like symptoms and fetal growth restriction // Sci. Rep. 2019. Vol. 9. No. 1. P. 2742. DOI: 10.1038/s41598-019-39426-5 |
| [29] |
Qu H, Yu Q, Jia B, et al. HIF-3 affects preeclampsia development by regulating EVT growth via activation of the Flt-1/JAK/STAT signaling pathway in hypoxia. Mol Med Rep. 2021;23(1):1. DOI: 10.3892/mmr.2020.11701 |
| [30] |
Qu H., Yu Q., Jia B. et al. HIF-3 affects preeclampsia development by regulating EVT growth via activation of the Flt-1/JAK/STAT signaling pathway in hypoxia // Mol. Med. Rep. 2021. Vol. 23. No. 1. P. 1. DOI: 10.3892/mmr.2020.11701 |
| [31] |
Jena MK, Sharma NR, Petitt M, et al. Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta. Biomolecules. 2020;10(6):953. DOI: 10.3390/biom10060953 |
| [32] |
Jena M.K., Sharma N.R., Petitt M. et al. Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta // Biomolecules. 2020. Vol. 10. No. 6. P. 953. DOI: 10.3390/biom10060953 |
| [33] |
Yagel S, Cohen SM, Goldman-Wohl D. An integrated model of preeclampsia: a multifaceted syndrome of the maternal cardiovascular-placental-fetal array. American journal of obstetrics and gynecology. 2020;S0002-9378(20)31197−31202. DOI: 10.1016/j.ajog.2020.10.023 |
| [34] |
Yagel S., Cohen S.M., Goldman-Wohl D. An integrated model of preeclampsia: a multifaceted syndrome of the maternal cardiovascular-placental-fetal array // Am. J. Obst. Gynecol. 2020. Vol. S0002-9378. No. 20. P. 31197−31202. DOI: 10.1016/j.ajog.2020.10.023 |
| [35] |
Vaka VR, McMaster KM, Cunningham MW Jr., et al. Role of mitochondrial dysfunction and reactive oxygen species in mediating hypertension in the reduced uterine perfusion pressure rat model of preeclampsia. Hypertension. 2018;72(3):703−711. DOI: 10.1161/hypertensionaha.118.11290 |
| [36] |
Vaka V.R., McMaster K.M., Cunningham M.W. Jr. et al. Role of mitochondrial dysfunction and reactive oxygen species in mediating hypertension in the reduced uterine perfusion pressure rat model of preeclampsia // Hypertension. 2018. Vol. 72. No. 3. P. 703−711. DOI: 10.1161/hypertensionaha.118.11290 |
| [37] |
Pogorelova TN, Krukier II, Gunko VO, et al. The imbalance of vasoactive components and arachidonic acid in the placenta and amniotic fluid in preeclampsia. Biomedicinskaja himija. 2019;65(3):245−250. (In Russ.). DOI: 10.18097/PBMC20196503245 |
| [38] |
Погорелова Т.Н., Крукиер И.И., Гунько В.О. и др. Дисбаланс вазоактивных компонентов и арахидоновой кислоты в плаценте и околоплодных водах при преэклампсии // Биомедицинская химия. 2019. Т. 65. № 3. С. 245−250. DOI: 10.18097/PBMC20196503245 |
| [39] |
Taysi S, Tascan AS, Ugur MG, Demir M. Radicals, oxidative/nitrosative stress and preeclampsia. Mini Rev Med Chem. 2019;19(3):178−193. DOI: 10.2174/1389557518666181015151350 |
| [40] |
Taysi S., Tascan A.S., Ugur M.G., Demir M. Radicals, oxidative/nitrosative stress and preeclampsia // Mini Rev. Med. Chem. 2019. Vol. 19. No. 3. P. 178−193. DOI: 10.2174/1389557518666181015151350 |
| [41] |
Tenório MB, Ferreira RC, Moura FA, et al. Cross-talk between oxidative stress and inflammation in preeclampsia. Oxid Med Cell Longev. 2019;2019:8238727. DOI: 10.1155/2019/8238727 |
| [42] |
Tenório M.B., Ferreira R.C., Moura F.A. et al. Cross-talk between oxidative stress and inflammation in preeclampsia // Oxid Med. Cell Longev. 2019. Vol. 2019. P. 8238727. DOI: 10.1155/2019/8238727 |
| [43] |
Tal R, Shaish A, Barshack I, et al. Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction. Am J Pathol. 2010;177:2950–2962. DOI: 10.2353/ajpath.2010.090800 |
| [44] |
Tal R., Shaish A., Barshack I. et al. Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction // Am. J. Pathol. 2010. Vol. 177. P. 2950–2962. DOI: 10.2353/ajpath.2010.090800 |
| [45] |
Wang A, Rana S, Karumanchi SA. Preeclampsia: the role of angiogenic factors in its pathogenesis. Physiology (Bethesda). 2009;24:147−158. DOI: 10.1152/physiol.00043.2008 |
| [46] |
Wang A., Rana S., Karumanchi S.A. Preeclampsia: the role of angiogenic factors in its pathogenesis // Physiology (Bethesda). 2009. Vol. 24. P. 147−158. DOI: 10.1152/physiol.00043.2008 |
| [47] |
Reshetnikov E, Ponomarenko I, Golovchenko O, et al. The VNTR polymorphism of the endothelial nitric oxide synthase gene and blood pressure in women at the end of pregnancy. Taiwanese Journal of Obstetrics and Gynecology. 2019;58(3):390−395. DOI: 10.1016/j.tjog.2018.11.035 |
| [48] |
Reshetnikov E., Ponomarenko I., Golovchenko O. et al. The VNTR polymorphism of the endothelial nitric oxide synthase gene and blood pressure in women at the end of pregnancy // Taiwanese J. Obst. Gynecol. 2019. Vol. 58. No. 3. P. 390−395. DOI: 10.1016/j.tjog.2018.11.035 |
| [49] |
Steinberg G, Khankin EV, Karumanchi SA. Angiogenic factors and preeclampsia. Thromb Res. 2009;123(Suppl 2):S93−99. DOI: 10.1016/S0049-3848(09)70020-9 |
| [50] |
Steinberg G., Khankin E.V., Karumanchi S.A. Angiogenic factors and preeclampsia // Thromb. Res. 2009. Vol. 123. Suppl. 2. P. S93−99. DOI: 10.1016/S0049-3848(09)70020-9 |
| [51] |
Iskakova SS, Zharmahanova GM, Dvoracka M. Harakteristika proangiogennyh faktorov i ih patogeneticheskaja rol’. Nauka i zdravoohranenie. 2013;(6):8−12. (In Russ.) |
| [52] |
Искакова С.С., Жармаханова Г.М., Дворацка М. Характеристика проангиогенных факторов и их патогенетическая роль // Наука и здравоохранение. 2013. № 6. C. 8−12. |
| [53] |
Strizhakov AN, Timokhina EV, Ibragimova SM, et al. A novel approach to the differential prognosis of early and late preeclampsia. Akusherstvo, ginekologija i reprodukcija. 2018;12(2):55−61. (In Russ.). DOI: 10.17749/2313-7347.2018.12.2.055-061 |
| [54] |
Стрижаков А.Н., Тимохина Е.В., Ибрагимова С.М. и др. Новые возможности дифференциального прогнозирования ранней и поздней преэклампсии // Акушерство, гинекология и репродукция. 2018. Т. 12. № 2. С. 55−61. DOI: 10.17749/2313-7347.2018.12.2.055-061 |
| [55] |
Chen J, Khalil RA. Matrix metalloproteinases in normal pregnancy and preeclampsia. Prog Mol Biol Transl Sci. 2017;148:87−165. DOI: 10.1016/bs.pmbts.2017.04.001 |
| [56] |
Chen J., Khalil R.A. Matrix metalloproteinases in normal pregnancy and preeclampsia // Prog. Mol. Biol. Transl. Sci. 2017. Vol. 148. P. 87−165. DOI: 10.1016/bs.pmbts.2017.04.001 |
| [57] |
Reshetnikov EA, Akulova LY, Dobrodomova IS, et al. The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy. J Renin Angiotensin Aldosterone Syst. 2015;16(3):623−632. DOI: 10.1177/1470320313501217 |
| [58] |
Reshetnikov E.A., Akulova L.Y., Dobrodomova I.S. et al. The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy // J. Renin. Angiotensin Aldosterone Syst. 2015. Vol. 16. No. 3. P. 623−632. DOI: 10.1177/1470320313501217 |
| [59] |
Herse F, LaMarca B. Angiotensin II type 1 receptor autoantibody (AT1-AA)-mediated pregnancy hypertension. Am J Reprod Immunol. 2013;69:413–418. DOI: 10.1111/aji.12072 |
| [60] |
Herse F., LaMarca B. Angiotensin II type 1 receptor autoantibody (AT1-AA)-mediated pregnancy hypertension // Am. J. Reprod. Immunol. 2013. Vol. 69. P. 413–418. DOI: 10.1111/aji.12072 |
| [61] |
Cunningham MW, Williams JM Jr, Amaral L, et al. Agonistic autoantibodies to the angiotensin II type 1 receptor enhance angiotensin II-induced renal vascular sensitivity and reduce renal function during pregnancy. Hypertension. 2016;68(5):1308–1313. DOI: 10.1161/HYPERTENSIONAHA.116.07971 |
| [62] |
Cunningham M.W., Williams J.M. Jr, Amaral L. et al. Agonistic autoantibodies to the angiotensin II type 1 receptor enhance angiotensin II-induced renal vascular sensitivity and reduce renal function during pregnancy // Hypertension. 2016. Vol. 68. No. 5. P. 1308–1313. DOI: 10.1161/HYPERTENSIONAHA.116.07971 |
| [63] |
Aneman I, Pienaar D, Suvakov S, et al. Mechanisms of key innate immune cells in early- and late-onset preeclampsia. Front Immunol. 2020;11:1864. DOI: 10.3389/fimmu.2020. 01864 |
| [64] |
Aneman I., Pienaar D., Suvakov S. et al. Mechanisms of key innate immune cells in early- and late-onset preeclampsia // Front. Immunol. 2020. Vol. 11. P. 1864. DOI: 10.3389/fimmu. 2020. 01864 |
| [65] |
Yang X, Yang Y, Yuan Y, et al. The roles of uterine natural killer (NK) cells and KIR/HLA-C combination in the development of preeclampsia: A systematic review. BioMed research international. 2020;2020:4808072. DOI: 10.1155/2020/4808072 |
| [66] |
Yang X., Yang Y., Yuan Y. et al. The roles of uterine natural killer (NK) cells and KIR/HLA-C combination in the development of preeclampsia: A systematic review // Biomed. Res. Int. 2020. Vol. 2020. P. 4808072. DOI: 10.1155/2020/4808072 |
| [67] |
Phipps EA, Thadhani R, Benzing T, et al. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019;15:275–289. DOI: 10.1038/s41581-019-0119-6 |
| [68] |
Phipps E.A., Thadhani R., Benzing T. et al. Pre-eclampsia: pathogenesis, novel diagnostics and therapies // Nat. Rev. Nephrol. 2019. Vol. 15. P. 275–289. DOI: 10.1038/s41581-019-0119-6 |
| [69] |
Kudryavtsev IV, Borisov AG, Vasilyeva EV, et al. Phenotypic characterisation of peripheral blood cytotoxic T lymphocytes: regulatory and effector molecules. Medicinskaja immunologija. 2018;20(2):227−240. (In Russ.). DOI: 10.15789/1563-0625-2018-2-227-240 |
| [70] |
Кудрявцев И.В., Борисов А.Г., Васильева Е.В. и др. Фенотипическая характеристика цитотоксических Т-лимфоцитов: регуляторные и эффекторные молекулы // Медицинская иммунология. 2018. Т. 20. № 2. С. 227−240. DOI: 10.15789/1563-0625-2018-2-227-240 |
| [71] |
Robertson SA, Care AS, Moldenhauer LM. Regulatory T cells in embryo implantation and the immune response to pregnancy. J Clin Invest. 2018;128(10):4224−4235. DOI: 10.1172/JCI122182 |
| [72] |
Robertson S.A., Care A.S., Moldenhauer L.M. Regulatory T cells in embryo implantation and the immune response to pregnancy // J. Clin. Invest. 2018. Vol. 128. No. 10. P. 4224−4235. DOI: 10.1172/JCI122182 |
| [73] |
Frejdlin IS. Reguljatornye T-kletki: proishozhdenie i funkcii. Medicinskaja immunologija. 2005;7(4):347−354. (In Russ.) |
| [74] |
Фрейдлин И.С. Регуляторные Т-клетки: происхождение и функции // Медицинская иммунология. 2005. Т. 7. № 4. С. 347−354. |
| [75] |
Teirilä L, Heikkinen-Eloranta J, Kotimaa J, et al. Regulation of the complement system and immunological tolerance in pregnancy. Semin immunol. 2019;45:101337. DOI: 10.1016/j.smim.2019.101337 |
| [76] |
Teirilä L., Heikkinen-Eloranta J., Kotimaa J. et al. Regulation of the complement system and immunological tolerance in pregnancy // Semin. Immunol. 2019. Vol. 45. P. 101337. DOI: 10.1016/j.smim.2019.101337 |
| [77] |
Ives CW, Sinkey R, Rajapreyar I, et al. Preeclampsia-pathophysiology and clinical presentations: JACC State-of-the-Art review. J Am Coll Cardiol. 2020;76(14):1690−1702. DOI: 10.1016/j.jacc.2020.08.014 |
| [78] |
Ives C.W., Sinkey R., Rajapreyar I. et al. Preeclampsia-pathophysiology and clinical presentations: JACC State-of-the-Art review // J. Am. Coll. Cardiol. 2020. Vol. 76. No. 14. P. 1690−1702. DOI: 10.1016/j.jacc.2020.08.014 |
| [79] |
Verdonk K, Visser W, Van Den Meiracker AH, Danser AH. The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad. Clin Sci (Lond). 2014;126(8):537−544. DOI: 10.1042/CS20130455 |
| [80] |
Verdonk K., Visser W., Van Den Meiracker A.H., Danser A.H. The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad // Clin. Sci. 2014. Vol. 126. No. 8. P. 537−544. DOI: 10.1042/CS20130455 |
| [81] |
LaMarca B, Cornelius DC, Harmon AC, et al. Identifying immune mechanisms mediating the hypertension during preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2016;311(1):R1−9. DOI: 10.1152/ajpregu.00052.2016 |
| [82] |
LaMarca B., Cornelius D.C., Harmon A.C. et al. Identifying immune mechanisms mediating the hypertension during preeclampsia // Am. J. Physiol. Regul. Integr. Comp. Physiol. 2016. Vol. 311. No. 1. P. R1−9. DOI: 10.1152/ajpregu.00052.2016 |
| [83] |
Giannakou K, Evangelou E, Papatheodorou SI. Genetic and non-genetic risk factors for pre-eclampsia: umbrella review of systematic reviews and meta-analyses of observational studies. Ultrasound Obstet Gynecol. 2018;51(6):720−730. DOI: 10.1002/uog.18959 |
| [84] |
Giannakou K., Evangelou E., Papatheodorou S.I. Genetic and non-genetic risk factors for pre-eclampsia: umbrella review of systematic reviews and meta-analyses of observational studies // Ultrasound Obstet. Gynecol. 2018. Vol. 51. No. 6. P. 720−730. DOI: 10.1002/uog.18959 |
| [85] |
Golovchenko OV, Abramova MYu, Ponomarenko IV, Churnosov MI. Polymorphic loci of the ESR1 gene are associated with the risk of developing preeclampsia with fetal growth retardation. Akusherstvo, Ginekologija i Reprodukcija. 2020;14(6):583–591. (In Russ.). DOI: 10.17749/2313-7347/ob.gyn.rep.2020.187 |
| [86] |
Головченко О.В., Абрамова М.Ю., Пономаренко И.В., Чурносов М.И. Полиморфные локусы гена ESR1 ассоциированы с риском развития преэклампсии с задержкой роста плода // Акушерство, гинекология и репродукция. 2020. Т. 14. № 6. С. 583–591. DOI: 10.17749/2313-7347/ob.gyn.rep.2020.187 |
| [87] |
Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124(7):1094−1112. DOI: 10.1161/CIRCRESAHA.118.313276 |
| [88] |
Rana S., Lemoine E., Granger J.P., Karumanchi S.A. Preeclampsia: pathophysiology, challenges, and perspectives // Circ. Res. 2019. Vol. 124. No. 7. P. 1094−1112. DOI: 10.1161/CIRCRESAHA.118.313276 |
| [89] |
Panaitescu AM, Syngelaki A, Prodan N, et al. Chronic hypertension and adverse pregnancy outcome: a cohort study. Ultrasound Obstet Gynecol. 2017;50(2):228−235. DOI: 10.1002/uog.17493 |
| [90] |
Panaitescu A.M., Syngelaki A., Prodan N. et al. Chronic hypertension and adverse pregnancy outcome: a cohort study // Ultrasound Obstet. Gynecol. 2017. Vol. 50. No. 2. P. 228−235. DOI: 10.1002/uog.17493 |
| [91] |
Nzelu D, Dumitrascu-Biris D, Nicolaides KH, Kametas NA. Chronic hypertension: first-trimester blood pressure control and likelihood of severe hypertension, preeclampsia, and small for gestational age. Am J Obstet Gynecol. 2018;218(3):337.e1−337.e7. DOI: 10.1016/j.ajog.2017.12.235 |
| [92] |
Nzelu D., Dumitrascu-Biris D., Nicolaides K.H., Kametas N.A. Chronic hypertension: first-trimester blood pressure control and likelihood of severe hypertension, preeclampsia, and small for gestational age // Am. J. Obstet. Gynecol. 2018. Vol. 218. No. 3. P. 337.e1−337.e7. DOI: 10.1016/j.ajog.2017.12.235 |
| [93] |
He XJ, Dai RX, Hu CL. Maternal prepregnancy overweight and obesity and the risk of preeclampsia: A meta-analysis of cohort studies. Obes Res Clin Pract. 2020;14(1):27−33. DOI: 10.1016/j.orcp.2020.01.004 |
| [94] |
He X.J., Dai R.X., Hu C.L. Maternal prepregnancy overweight and obesity and the risk of preeclampsia: A meta-analysis of cohort studies // Obes. Res. Clin. Pract. 2020. Vol. 14. No. 1. P. 27−33. DOI: 10.1016/j.orcp.2020.01.004 |
| [95] |
Lewandowska M, Więckowska B, Sajdak S, Lubiński J. Pre-pregnancy obesity vs. other risk factors in probability models of preeclampsia and gestational hypertension. Nutrients. 2020;12(9):2681. DOI: 10.3390/nu12092681 |
| [96] |
Lewandowska M., Więckowska B., Sajdak S., Lubiński J. Pre-pregnancy obesity vs. other risk factors in probability models of preeclampsia and gestational hypertension // Nutrients. 2020. Vol. 12. No. 9. P. 2681. DOI: 10.3390/nu12092681 |
| [97] |
Kalinkina OB, Spiridonova NV. Osobennosti techenija gestoza u zhenshhin s izbytochnoj massoj tela i ozhireniem. Fundamental’nye issledovanija. 2012;10(2):247−249. (In Russ.) |
| [98] |
Калинкина О.Б., Спиридонова Н.В. Особенности течения гестоза у женщин с избыточной массой тела и ожирением // Фундаментальные исследования. 2012. Т. 10. № 2. С. 247−249. |
| [99] |
Brosens I, Pijnenborg R, Vercruysse L, Romero R. The “Great Obstetrical Syndromes” are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204(3):193−201. DOI: 10.1016/j.ajog.2010.08.009 |
| [100] |
Brosens I., Pijnenborg R., Vercruysse L., Romero R. The “Great Obstetrical Syndromes” are associated with disorders of deep placentation // Am. J. Obstet. Gynecol. 2011. Vol. 204. No. 3. P. 193−201. DOI: 10.1016/j.ajog.2010.08.009 |
| [101] |
Mello G, Parretti E, Marozio L, et al. Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study. Hypertension. 2005;46(6):1270−1274. DOI: 10.1161/01.HYP.0000188979.74172.4d |
| [102] |
Mello G., Parretti E., Marozio L. et al. Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study // Hypertension. 2005. Vol. 46. No. 6. P. 1270−1274. DOI: 10.1161/01.HYP.0000188979.74172.4d |
| [103] |
Belinina AA, Mozgovaya EV, Remneva OV. Spectrum of genetic thrombophilia in pregnant women with varying severity of preeclampsia. Bjulleten’ medicinskoj nauki. 2020;1(17):29−33. (In Russ.) |
| [104] |
Белинина А.А., Мозговая Е.В., Ремнёва О.В. Спектр генетических тромбофилий у беременных с различной степенью тяжести преэклампсии // Бюллетень медицинской науки. 2020. Т. 1. № 17. C. 29−33. |
| [105] |
Mitriuc D, Popuşoi O, Catrinici R, Friptu V. The obstetric complications in women with hereditary thrombophilia. Med Pharm Rep. 2019;92(2):106−110. DOI: 10.15386/cjmed-1097 |
| [106] |
Mitriuc D., Popuşoi O., Catrinici R., Friptu V. The obstetric complications in women with hereditary thrombophilia // Med. Pharm. Rep. 2019. Vol. 92. No. 2. P. 106−110. DOI: 10.15386/cjmed-1097 |
| [107] |
Kapustin RV, Tsybuk EM. Predictors for preeclampsia in pregnant women with diabetes mellitus. Obstetrics and Gynecology. 2020;(12):54−61. (In Russ.). DOI: 10.18565/aig.2020.12.54-61 |
| [108] |
Капустин Р.В., Цыбук Е.М. Предикторы преэклампсии у беременных с сахарным диабетом // Акушерство и гинекология. 2020. № 12. C. 54−56. DOI: 10.18565/aig.2020.12.54-61 |
| [109] |
Lisonkova S, Joseph KS. Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease. Am J Obstet Gynecol. 2013;209(6):544.e1−544.e12. DOI: 10.1016/j.ajog.2013.08.019 |
| [110] |
Lisonkova S., Joseph K.S. Incidence of preeclampsia: risk factors and outcomes associated with early-versus late-onset disease // Am. J. Obstet. Gynecol. 2013. Vol. 209. No. 6. P. 544.e1−544.e12. DOI: 10.1016/j.ajog.2013.08.019 |
| [111] |
Bramham K. Diabetic nephropathy and pregnancy. Semin Nephrol. 2017;37(4):362−369. DOI: 10.1016/j.semnephrol.2017.05.008 |
| [112] |
Bramham K. Diabetic nephropathy and pregnancy // Semin. Nephrol. 2017. Vol. 37. No. 4. P. 362−369. DOI: 10.1016/j.semnephrol.2017.05.008 |
| [113] |
Hauth JC, Clifton RG, Roberts JM, et al. Maternal insulin resistance and preeclampsia. Am J Obstet Gynecol. 2011;204(4):327.e1−6. DOI: 10.1016/j.ajog.2011.02.024 |
| [114] |
Hauth J.C., Clifton R.G., Roberts J.M. et al. Maternal insulin resistance and preeclampsia // Am. J. Obstet. Gynecol. 2011. Vol. 204. No. 4. P. 327.e1−6. DOI: 10.1016/j.ajog.2011.02.024 |
| [115] |
Boyd HA, Tahir H, Wohlfahrt J, Melbye M. Associations of personal and family preeclampsia history with the risk of early-, intermediate- and late-onset preeclampsia. Am J Epidemiol. 2013;178(11):1611−1619. DOI: 10.1093/aje/kwt189 |
| [116] |
Boyd H.A., Tahir H., Wohlfahrt J., Melbye M. Associations of personal and family preeclampsia history with the risk of early-, intermediate- and late-onset preeclampsia // Am. J. Epidemiol. 2013. Vol. 178. No. 11. P. 1611−1619. DOI: 10.1093/aje/kwt189 |
| [117] |
Caughey AB, Stotland NE, Washington AE, Escobar GJ. Maternal ethnicity, paternal ethnicity, and parental ethnic discordance: predictors of preeclampsia. Obstet Gynecol. 2005;106(1):156−161. DOI: 10.1097/01.AOG.0000164478.91731.06 |
| [118] |
Caughey A.B., Stotland N.E., Washington A.E., Escobar G.J. Maternal ethnicity, paternal ethnicity, and parental ethnic discordance: predictors of preeclampsia // Obstet. Gynecol. 2005. Vol. 106. No. 1. P. 156−161. DOI: 10.1097/01.AOG.0000164478.91731.06 |
| [119] |
Gyamfi-Bannerman C, Pandita A, Miller EC, et al. Preeclampsia outcomes at delivery and race. J Matern Fetal Neonatal Med. 2020;33(21):3619−3626. DOI: 10.1080/14767058.2019.1581522 |
| [120] |
Gyamfi-Bannerman C., Pandita A., Miller E.C. et al. Preeclampsia outcomes at delivery and race // J. Matern. Fetal. Neonatal. Med. 2020. Vol. 33. No. 21. P. 3619−3626. DOI: 10.1080/14767058.2019.1581522 |
| [121] |
Zhang N, TanJ, Yang H, Khalil RA. Comparative risks and predictors of preeclamptic pregnancy in the Eastern, Western and developing world. Biochem Pharmacol. 2020;182:114247. DOI: 10.1016/j.bcp.2020.114247 |
| [122] |
Zhang N., Tan J., Yang H., Khalil R.A. Comparative risks and predictors of preeclamptic pregnancy in the Eastern, Western and developing world // Biochem. Pharmacol. 2020. Vol. 182. P. 114247. DOI: 10.1016/j.bcp.2020.114247 |
| [123] |
Yong HEJ, Murthi P, Brennecke SP, Moses EK. Genetic approaches in preeclampsia. Methods Mol Biol. 2018;1710:53−72. DOI: 10.1007/978-1-4939-7498-6_5 |
| [124] |
Yong H.E.J., Murthi P., Brennecke S.P., Moses E.K. Genetic approaches in preeclampsia // Methods Mol. Biol. 2018. Vol. 1710. P. 53−72. DOI: 10.1007/978-1-4939-7498-6_5 |
| [125] |
Serrano NC, Quintero-Lesmes DC, Dudbridge F, et al. Family history of pre-eclampsia and cardiovascular disease as risk factors for pre-eclampsia: the GenPE case-control study. Hypertens Pregnancy. 2020;39(1):56−63. DOI: 10.1080/10641955.2019.1704003 |
| [126] |
Serrano N.C., Quintero-Lesmes D.C., Dudbridge F. et al. Family history of pre-eclampsia and cardiovascular disease as risk factors for pre-eclampsia: the GenPE case-control study // Hypertens Pregnancy. 2020. Vol. 39. No. 1. P. 56−63. DOI: 10.1080/10641955.2019.1704003 |
| [127] |
Bezerra PC, Leão MD, Queiroz JW, et al. Family history of hypertension as an important risk factor for the development of severe preeclampsia. Acta Obstet Gynecol Scand. 2010;89(5):612−617. DOI: 10.3109/00016341003623720 |
| [128] |
Bezerra P.C., Leão M.D., Queiroz J.W. et al. Family history of hypertension as an important risk factor for the development of severe preeclampsia // Acta Obstet. Gynecol. Scand. 2010. Vol. 89. No. 5. P. 612−617. DOI: 10.3109/00016341003623720 |
| [129] |
Ness RB, Markovic N, Bass D, et al. Family history of hypertension, heart disease, and stroke among women who develop hypertension in pregnancy. Obstet Gynecol. 2003;102(6):1366−1371. DOI: 10.1016/j.obstetgynecol.2003.08.011 |
| [130] |
Ness R.B., Markovic N., Bass D. et al. Family history of hypertension, heart disease, and stroke among women who develop hypertension in pregnancy // Obstet. Gynecol. 2003. Vol. 102. No. 6. P. 1366−1371. DOI: 10.1016/j.obstetgynecol.2003.08.011 |
Eсо-Vector
/
| 〈 |
|
〉 |