Role of maternal melatonin in the development of the microbiome in children

Abstract

This review presents literature data on the role of melatonin in regulating the composition of the microbiota and on the variety of functions it performs that are synchronized with the circadian rhythm of vital activity of the body. During pregnancy, the restructuring of the intestinal, vaginal and placental microbiota is provided by a significant increase in the production of epiphyseal melatonin, which contributes to the creation of optimal conditions for the development of microflora in early ontogenesis. In the absence of circadian production of melatonin, a pregnant woman retains dysbiosis, which determines the transmission of altered intestinal microflora to the fetus and subsequent metabolic dysregulation in the child’s body.

Keywords

microbiota / melatonin / pregnancy / placenta / fetus

RIGHTS & PERMISSIONS

Evsyukova I.I., Ailamazyan E.K.