Pathomorphological features of the endometrium in patients with abnormal uterine bleeding in the presence of uterine leiomyoma

Zoya S. Rumyantseva; Anna N. Sulima; Nadezhda I. Volotskaya; Evgenia Yu. Zyablitskaya; Sergey S. Anikin; Ilya S. Glazkov; Aishe A. Keshvedinova

doi:10.17816/JOWD69681-89

Journal of obstetrics and women's diseases ›› 2020, Vol. 69 ›› Issue (6) : 81 -89. DOI: 10.17816/JOWD69681-89

Original study articles

research-article

Pathomorphological features of the endometrium in patients with abnormal uterine bleeding in the presence of uterine leiomyoma

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Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University

Medical Academy named after S. I. Georgievsky (structural unit) “V. I. Vernadsky Crimean Federal University"

Simferopol Clinical Maternity Hospital No. 2

MD, PhD, Assistant Professor, Acting Head of the Department of Obstetrics, Gynecology, and Perinatology No. 1, the First Medical Faculty

MD, PhD, DSci (Medicine), Professor. The Department of Obstetrics, Gynecology, and Perinatology No. 1, the First Medical Faculty

Resident. The Department of Obstetrics, Gynecology, and Perinatology No. 1, the First Medical Faculty

MD, PhD, DSci (Medicine), Leading Researcher, Head of the Central Research Laboratory

MD, PhD, Assistant Professor. The Department of Obstetrics, Gynecology, and Perinatology No. 1, the First Medical Faculty

MD, PhD, DSci (Medicine), Professor, Head

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Abstract

Hypothesis/Aims of study. One of the problems discussed in the field of obstetrics and gynecology is the combined pathology of the reproductive system. Among the female reproductive system disorders associated with uterine leiomyoma, endometrial pathology prevails in the form of local inflammatory, receptor and hormonal changes. The aim of this study was to evaluate the structural features of the endometrium and its receptivity in patients with uterine leiomyoma, depending on its histological type and localization.

Study design, materials and methods. We examined 128 women with leiomyoma manifesting abnormal uterine bleeding, using clinical, instrumental and morphological methods.

Results. Combined pathological changes in the endometrium are more characteristic of submucous leiomyoma compared to intramural and subserous leiomyomas. The proliferative activity of endometrial cells in submucous leiomyoma is two or more times higher than in intramural and subserous leiomyoma. In submucous leiomyoma, cell proliferation occurs significantly more often than in other locations of myomatous nodes.

Keywords

leiomyoma / abnormal uterine bleeding / endometrial receptivity / endometrial hyperplasia

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Zoya S. Rumyantseva, Anna N. Sulima, Nadezhda I. Volotskaya, Evgenia Yu. Zyablitskaya, Sergey S. Anikin, Ilya S. Glazkov, Aishe A. Keshvedinova. Pathomorphological features of the endometrium in patients with abnormal uterine bleeding in the presence of uterine leiomyoma. Journal of obstetrics and women's diseases, 2020, 69(6): 81-89 DOI:10.17816/JOWD69681-89

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