Blood serum and follicular fluid relaxin: a pilot study of the hormone effects on ovarian function and fertilization efficiency

Olesya N. Bespalova; Valeriya A. Zagaynova; Olga V. Kosyakova; Alexander M. Gzgzyan; Igor Yu. Kogan; Yulia P. Milyutina; Natalia N. Tkachenko; Valentina L. Borodina; Elena A. Lesik; Irina D. Mekina; Evgenia M. Komarova

doi:10.17816/JOWD69559-68

Journal of obstetrics and women's diseases ›› 2020, Vol. 69 ›› Issue (5) : 59 -68. DOI: 10.17816/JOWD69559-68

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Blood serum and follicular fluid relaxin: a pilot study of the hormone effects on ovarian function and fertilization efficiency

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The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott

Saint Petersburg State University

the «Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott"

The «Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott»

The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott

MD, PhD, DSci (Medicine), Deputy Director

MD, Post-Graduate Student. The Assisted Reproduction Technology Department

MD, Post-Graduate Student. The Department of Pathology of Pregnancy N 1

MD, PhD, DSci (Medicine), Head of the Department of Reproductology, Head of the Assisted Reproduction Technology Department; Professor. The Department of Obstetrics, Gynecology, and Reproductive Sciences, the Faculty of Medicine

MD, PhD, DSci (Medicine), Professor, Corresponding Member of RAS, Director; Professor. The Department of Obstetrics, Gynecology, and Reproductive Sciences, the Faculty of Medicine

PhD, Chairman of the Council of Young Scientists

PhD, Head of the Laboratory of Endocrinology

Laboratory Assistant. The Laboratory of Endocrinology

PhD, Senior Researcher. The Laboratory of Early Embryogenesis; Embryologist. The Assisted Reproduction Technology Department

PhD, Senior Researcher. The Laboratory of Early Embryogenesis; Senior Embryologist. The Assisted Reproduction Technology Department

PhD, Head of the Laboratory of Early Embryogenesis, Embryologist. The Assisted Reproduction Technology Department

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Abstract

Hypothesis/aims of study. To date, one of the most important avenues of research in the field of reproductive medicine is the searching for new biochemical markers of oocyte quality and the prediction of the effectiveness of in vitro fertilization (IVF) protocols. The aim of this study was to assess the effect of relaxin levels in blood serum and follicular fluid on the efficiency of ovulation stimulation, fertilization, and characteristics of the embryos.

Study design, materials and methods. This prospective randomized cohort study included 11 patients undergoing infertility treatment in a superovulation stimulation protocol using gonadotropin-releasing hormone antagonists. Age, body mass index, hormonal status, ovarian response, endometrial thickness and structure, the number and quality of oocytes and embryos, as well as fertilization efficiency were assessed. The level of relaxin in blood serum and follicular fluid samples was determined on the day of transvaginal follicle puncture using enzyme immunoassay.

Results. A correlation between follicular fluid relaxin levels and body mass index, age, the number of oocytes, and their fertilization efficiency (p < 0.05) was established. Changes in follicular fluid relaxin level were revealed depending on the gonadotropin preparations (p < 0.05) and triggers of final maturation of oocytes (p < 0.05). The tendency of the effect of gonadotropin doses on circulating relaxin levels, and of the hormone itself on endometrial thickness and the quality of oocytes was determined.

Conclusion. Determination of the relaxin concentration can be considered as a promising method for predicting the result of ovarian stimulation and the efficiency of fertilization in IVF protocols.

Keywords

relaxin / in vitro fertilization / follicular fluid / oocyte / fertilization efficiency / endometrium

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Olesya N. Bespalova,Valeriya A. Zagaynova,Olga V. Kosyakova,Alexander M. Gzgzyan,Igor Yu. Kogan,Yulia P. Milyutina,Natalia N. Tkachenko,Valentina L. Borodina,Elena A. Lesik,Irina D. Mekina,Evgenia M. Komarova. Blood serum and follicular fluid relaxin: a pilot study of the hormone effects on ovarian function and fertilization efficiency. Journal of obstetrics and women's diseases, 2020, 69(5): 59-68 DOI:10.17816/JOWD69559-68

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Bespalova O.N., Zagaynova V.A., Kosyakova O.V., Gzgzyan A.M., Kogan I.Y., Milyutina Y.P., Tkachenko N.N., Borodina V.L., Lesik E.A., Mekina I.D., Komarova E.M.