The role of vitamin D in the pathogenesis of genital endometriosis

Abstract

The influence of vitamin D on the women’s health is undeniable. Here we review the modern classification of vitamin D forms and receptors, the current understanding of genomic and non-genomic regulation pathways of vitamin D synthesis. It was found that a vitamin D deficiency related to the development of many diseases, negative impact on reproductive function and pregnancy outcomes. Nowadays, vitamin D is concerned as a prohormone that has multiple effects. Special attention is given to the role of vitamin D in the pathogenesis of genital endometriosis. It is known that vitamin D has anti-inflammatory, antiproliferative and immunomodulating effects, which allow it to be considered as a forward-looking target therapy in endometriosis.

Keywords

1,25(OH)2D3 / vitamin D / (OH)2D3 / cholecalciferol / receptor of vitamin D / genital endometriosis

References

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Denisova A.S., Yarmolinskaya M.I.