Premature newborns: Actual problems of raising and prevention of adverse consequences

Abstract

The review summarizes the literature data on the perinatal pathology of premature infants, the frequency of their development in the following months and years of life of neuropsychiatric and somatic diseases. The results of experimental and clinical studies are presented, revealing the general pathogenetic mechanism – oxidative stress, underlying bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, periventricular leukomalacia, open ductus arteriosus and persistent pulmonary hypertension. The interrelation of the processes of inflammation and oxidative stress, which play a leading role in the brain damage of the fetus and newborn, is considered. The literature data on the possibility of preventing severe complications in the antenatal period of development with the timely use of surfactant, magnesium sulfate and acetylcysteine are presented, It is emphasized that the first hours of a premature baby's life are a critical period for an individual approach to resuscitation, the beginning and effectiveness of drug therapy aimed at suppressing oxidative stress and systemic inflammation, which is confirmed by modern trends in optimizing the care of premature babies using pentoxifylline, erythropoietin, cortexin and melatonin.

Keywords

oxidative stress / prematurity / magnesium sulfate / acetylcysteine / cortexin / melatonin

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