The contents of neurospecific enolase and neurotrofic growth factor in the cord blood of healthy full-term newborns elective planned caesarean section surgery and spontaneous delivery

Abstract

The contents of neuron-specific enolase (NSE) and brain-derived neurotrophic factor (BDNF) was studied in the umbilical blood serum of healthy full-term newborns elective planned caesarean section and spontaneous delivery. The study has established that their levels in umbilical blood serum after elective planned caesarean section surgery are lover, than after spontaneous delivery. The authors of the article discuss the causes and possible effects of low levels of BDNF of newborns extrected elective planned caesarean section surgery before 39 weeks.

Keywords

elective caesarean section / newborn / NSE / BDNF

References

[1] Баканов М. И., Алатырцев В. В., Подкопаев В. Н. Креатинкиназа-ВВ и нейронспецифическая енолаза в цереброспинальной жидкости у новорожденных детей с перинатальными поражениями центральной нервной системы. Педиатрия. 1999; 2: 4-8.

[2] Блинов Д. В., Терентьев А. А. Характеристика биохимических маркеров нарушения проницаемости гематоэнцефалического барьера и функционирования центральной нервной системы. Нейрохимия. 2013; 30 (3): 179-92.

[3] Голосная Г. С., Петрухин А. С., Красильщикова Т. М., Албагачиева Д. И., Эрлих А. Л., Трепилец С. В. и соавт. Взаимодействие нейротрофических и проапоптотических факторов в патогенезе гипоксического поражения головного мозга у новорожденных. Педиатрия. 2010; 89 (1): 20-5.

[4] Кореновский Ю. В., Ельчанинова С. А. Биохимические маркеры гипоксических перинатальных поражений центральной нервной системы у новорожденных (обзор литературы). Клиническая лабораторная диагностика. 2012; 2: 3-7.

[5] Мухтарова С. Н. Значение определения нейронспецифической енолазы в оценке тяжести гипоксически-ишемических поражений мозга у новорожденных. Медицинские новости Грузии. 2010; 181 (4): 49-54.

[6] Bannett M., Lagopoulos J. Stress and trauma: BDNF control of dendritic-spine formation and regression. Prog. Neurobiol. 2014; 112: 80-99.

[7] Celtik C., Acunaş B., Oner N. et al. Neuron-specific enolase as a marker of the severity and outcome of hypoxic ischemic encephalopathy. Brain Development. 2004; 26 (6): 398-402.

[8] Chouthai N. S., Sampers J., Desai N. et al. Changes in neurotrophin levels in umbilical cord blood from infants with different gestational ages and clinical conditions. Pediatr. Res. 2003; 53 (6): 965-9.

[9] Costantine M. M., Weiner S. J., Rouse D. J. et al. Umbilical cord biomarkers of neurologic injury and the risk of cerebral palsy or infant death. Dev.Neurosci. 2011; 29 (8): 917-22.

[10] Dhobale M. Neurotrophins: role in adverse pregnancy outcome. Devl. Neuroscience. 2014; 37: 8-14.

[11] Douglas-Escobar M., Weiss M. D. Biomarkers of hypoxic-ischemic encephalopathy in newborns. Front. Neurol. 2012; 144 (2): 1-5.

[12] Flock A., Weber S. K., Ferrari N. et al. Determinants of brain-derived neurotrophic factor (BDNF) in umbilical cord and maternal serum. Psychoneuroendocrinology. 2016; 63: 191-7.

[13] Fujita K., Tatsumi K., Kondoh E. et al. Differential expression and the anti-apoptotic effect of human placental neurotrophins and their receptors. Placenta. 2011; 32: 737-44.

[14] Grow J., Barks J. D. Pathogenesis of hypoxic-ischemic cerebral injury in the term infant: current concepts. Clin Perinatol. 2002; 29 (4): 585-602.

[15] Haddad J., Vilge V., Juif J. G. et al. Beta-nerve growth factor levels in newborn cord sera. Pediatr. Res. 1994; 35: 637-9.

[16] Hamilton B. E., Hoyert D. I., Martin J. A. et al. Annual summaryof vital statistics: 2010-2011. Pediatrics. 2013; 131: 548-58.

[17] Hartman W., HelanM., Smelter D. et al. Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle. PloS ONE. 2015; 10 (7): e012I9489.

[18] Inoue S. A clinical study on neuron-specific enolase activities in cerebrospinal fluid of neonates. No To Hattatsu. 1992; 24 (6): 548-53.

[19] Irestedt l., Dahlin I., Hertzberg T., Sollevl A. et al. Adenosine Concentration in Umbilical Cord Blood of Newborn Infants after Vaginal Delivery and Cesarean Section. Pediatric. Res.1989; 26 (2): 106-8.

[20] Jauch E. C., Lindsell C., Broderick J. et al. Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study. Stroke. 2006; 37 (10): 2508-13.

[21] Karege F., Schwald M., Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett. 2002; 328: 261-8.

[22] Kelmanson I. Emotional andbehavioural features of preschool children born by caesarean deliveries at maternal request. Eur. J. Dev. Psychol. 2013; 10: 676-90.

[23] Leal G., Comprido D., Duarte C. B. BDNF-induced local protein synthesis and synaptic plasticity. Neuropharmacology. 2014; 76: 639-56.

[24] Malamitsi-Puchner A., Economou E., Rigopoulou A. et al. Perinatal changes of brain-derived neurotrophic factor in pre- and fullterm neonates. Early Hum. 2004; 76: 17-22.

[25] Matoba N., Yu Y., Mestan K. et al. Differential pattern of 27 cord blood ummune biomarkers across ge4stational age. Pediatrics. 2009; 123: 1320-8.

[26] Matthews V. B., Astrom M.-V., Chan M. H. S. et al. Brain derived neutrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMPK. Diabetologia. 2009; 52: 1409-18.

[27] Meuchel L. W., Thompson M. A., Cassivi S. D. et al. Neurotrophins induce nitric oxide generation in human pulmonary artery endothelial cells. Cardiovascular Research. 2011; 91: 668-6.

[28] Morel A. A., Bailey S. M., Shaw G. et al. Measurement of novel biomarkers of neuronal injury and cerebral oxygenation after routine vaginal delivery versus cesarean section in term infants. Perinat. Med. 2014; 42 (6): 705-9.

[29] Ng P. C., Lam H. S. Biomarkers in Neonatology: The Next Generation of Tests. Neonatology. 2012; 102: 145-1.

[30] Ohmiya M., Shudai T., Nitta A. et al. Brain-derived neurotrophic factor alters cell migration of particular progenitors in the developing mouse cerebral cortex. Neuroscience Letters. 2002; 317: 21-4.

[31] Olza-Fernandez I., Gabriel M. A. M., Gil-Sanchez A. et al. Neuroendocrinology of childbirth and mother-child attachment: The basis of an etiopathogenic model of perinatal neurobiological disorders. Frontiers in Neuroendocrinology. 2014; 35: 459-72.

[32] Pan W., Banks W. A., Fasold M. B. et al. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 1998; 37: 1553-61.

[33] Panja D., Bramham C. R. BDNF mechanisms in late LTP formation: a synthesis and break down. Neuropharmacology. 2014; 76: 664-76.

[34] Parkhurst C.N., Yang G., Ninan I. et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013; 155 (7): 1596-609.

[35] Pedersen B. K., Pedersen M., Krabbe K. S. et al. Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeosyasis in mammals. Exp. Physiol. 2009; 94 (12): 1153-60.

[36] Shu C., Xiao L., Tang J. et al. Blunted Behavioral and Molecular Responses to Chronic Mild Stress in Adult Rats with Experience of Infancy Maternal Separation. Tohoku J. Exper. Med. 2015; 235: 81-7.

[37] Smith P. A. BDNF: no gain without pain? Neuroscience. 2014; 283: 107-23.

RIGHTS & PERMISSIONS

Morozova A.Y., Milyutina Y.P., Arutyunyan A.V., Evsyukova I.I.