Diagnostic value of p16inkα/Ki-67 Dual-stained cytology in HPV-associated cervical diseases
Armine Robertovna Khachaturyan , Ekaterina Konstantinovna Orekhova , Gulrukhsor Khaybulloevna Tolibova , Tatyana Georgiyevna Tral
Journal of obstetrics and women's diseases ›› 2015, Vol. 64 ›› Issue (3) : 47 -51.
Diagnostic value of p16inkα/Ki-67 Dual-stained cytology in HPV-associated cervical diseases
Human papillomavirus (HPV) infection is currently considered the most common of sexually transmitted infections. However, only 8-20 % of cases of infection with human papillomavirus oncogenic risk has the potential to transform to a neoplastic process. Detection of productive forms of HPV infection is the basis of early diagnosis of precancerous lesions. In order to clarify the severity of neoplasia and choose a sufficient way of treatment we investigated the diagnostic value of p16inkα/Ki-67 Dual-stained cytology method for assessing the presence and degree of expression of p16inkα protein and Ki-67, biomarkers of virus-induced proliferation, the sensitivity and positive predictive value of co-expression degree of which can increase the diagnostic value of cervical cytology.
Ki-67 / Human Papilloma virus / cervical intraepithelial neoplasia / cervical cancer screening methods
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Khachaturyan A.R., Orekhova E.K., Tolibova G.K., Tral T.G.
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