Synthesis of the matrix metalloproteinases and its inhibitors by peripheral blood phagocytes of women with hypertansion disorders

Irina Aleksandrovna Panova; Anna Ivanovna Malyshkina; Anna Vladimirovna Kudryashova; Daria Aleksandrovna Khlipunova; Elena Arkadyevna Rockatanskaya; Lyudmila Alekseevna Sytova

doi:10.17816/JOWD64326-32

Journal of obstetrics and women's diseases ›› 2015, Vol. 64 ›› Issue (3) : 26 -32. DOI: 10.17816/JOWD64326-32

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Synthesis of the matrix metalloproteinases and its inhibitors by peripheral blood phagocytes of women with hypertansion disorders

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Abstract

Development of the hypertension disorders in pregnant women is associated with the increase of the functional activity of innate immunity cells. RT-PCR assessment of the MMP-2 and TIMP-1 synthesis by peripheral blood phagocytes showed the significant elevation of the MMP-9 mRNA expression by neutrophils in women with chronic arterial hypertension (CAH) and TIMP-1 and TIMP-2 mRNA expression by monocytes in women with CAH and preeclampsia.

Keywords

pregnancy / hypertension disorders / matrix metalloproteinases / neutrophils / monocytes

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Irina Aleksandrovna Panova, Anna Ivanovna Malyshkina, Anna Vladimirovna Kudryashova, Daria Aleksandrovna Khlipunova, Elena Arkadyevna Rockatanskaya, Lyudmila Alekseevna Sytova. Synthesis of the matrix metalloproteinases and its inhibitors by peripheral blood phagocytes of women with hypertansion disorders. Journal of obstetrics and women's diseases, 2015, 64(3): 26-32 DOI:10.17816/JOWD64326-32

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