Features of a course of pregnancy at bronchial asthma and influence of immunological deposits on a placentary barrier

Elena Andreevna Shapovalova; Lyudmila Borisovna Zubzhitskaya; Ol’ga Vol’demarovna Lavrova; Ol’ga Nikolaevna Arzhanova; Yuliya Romanovna Dymarskaya

doi:10.17816/JOWD64269-75

Journal of obstetrics and women's diseases ›› 2015, Vol. 64 ›› Issue (2) : 69 -75. DOI: 10.17816/JOWD64269-75

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Features of a course of pregnancy at bronchial asthma and influence of immunological deposits on a placentary barrier

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Abstract

Studying of features of a course of pregnancy at the bronchial asthma (BA) and influence of immunological deposits on a placentary barrier was a research objective. Results of this research testify that the main complications of pregnancy at women with bronchial asthma is pregnancy interruption threat, gestosis and placentary insufficiency. Prevention, timely identification of these complications, joint maintaining patients by the obstetrician and pulmonologist allow women practically in all cases to give birth to the full-term healthy children. The greatest number of the immune deposits fixed in a placenta and damaging structures of a placentary barrier (endoteliya of vessels and a membrane of a sintsitiotrofoblast) is found in women with an average and a heavy current BA. Their adjournment is followed by morphological features of an immune inflammation, violation of an immune homeostasis in structures of a placentary barrier. Existence of pathogenic immune complexes in a placenta, and also detection with BA leads an antigen-presenting cells of cages in places of an immune inflammation at women to development of immunopathological process and placentary insufficiency that adversely affects the course of pregnancy, childbirth and can be a predictive factor of development of allergic diseases in the child.

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bronchial asthma / pregnancy / pathogenic immune complexes / placentary barrier / immune inflammation

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Elena Andreevna Shapovalova, Lyudmila Borisovna Zubzhitskaya, Ol’ga Vol’demarovna Lavrova, Ol’ga Nikolaevna Arzhanova, Yuliya Romanovna Dymarskaya. Features of a course of pregnancy at bronchial asthma and influence of immunological deposits on a placentary barrier. Journal of obstetrics and women's diseases, 2015, 64(2): 69-75 DOI:10.17816/JOWD64269-75

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