Clinical value of determination of markers of a thrombophylia at patients with the complicated pregnancy in the anamnesis

Abstract

The results of the survey of 214 patients with the complicated pregnancy (a preeclampsia, a premature detachment of placenta, antenatal fetal death, miscarriage) in the anamnesis are presented in the article. We determined the level of molecular markers of a thrombophilia (TAT, D-dimer) and aggregation activity of platelets and carried out antithrombotic therapy to these women. It is shown that 47,7 % of such nonpregnant women and pregnant early terms have the high level of D-dimer, TAT - 46,7 %, aggregation activity of platelets - 52,6 %. Determination of the increased levels of molecular markers of a thrombophilia is the indication to application the antithrombotic therapy and allow to control efficiency of this therapy.

Keywords

D-dimer / TAT / thrombophilia / markers of thrombophilia / preeclampsia / premature detachment of placenta / antenatal fetal death / miscarriage

RIGHTS & PERMISSIONS

Andreeva M.D.