Diagnostics and laboratory monitoring of gestational diabetes mellitus in Russia. The authors' view of the problem and controversial issues

Abstract

Despite the existence of the Russian Consensus on gestational diabetes mellitus (GDM) since 2012 in the Russian Federation, its implementation into clinical practice has been slow, partially because its creation took place without the participation of laboratory services. In this review issues of preanalytical and analytical considerations of such laboratory tests as the blood glucose test, oral glucose tolerance test (OGTT), glycosylated hemoglobin test are discussed. If the presence of prandial hyperglycemia from 5.1 to 5.6 mmol/l is identified, testing should be repeated to confirm the diagnosis of GDM. OGTT must be performed using venous blood samples with fluoride in a specialized laboratory with fast transportation of samples.

Keywords

gestational diabetes mellitus / gestation / diagnostics / venous blood glucose / oral glucose tolerance test

References

[1] Дедов И. И., Краснопольский В. И., Сухих Г. Т. Российский консенсус «Гестационный сахарный диабет: диагностика, лечение, послеродовое наблюдение». Сахарный диабет. 2012; 4: 4-10

[2] HAPO Study Cooperative Research Group: Metzger B., Lowe L., Dyer A. et al. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cooperative Research Group/Hyperglycemia and adverse pregnancy outcomes//N. Engl. J. Med. 2008; 358 (19): 1991-2002 (http://www.nejm.org/doi/pdf/10.1056/NEJMoa0707943).

[3] M. Hedderson, E. Gunderson, A. Ferrara. Gestational weight gain and risk of gestational diabetes mellitus.//Obstet. Gynecol. 2010; 115 (3): 597-604.

[4] International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010; 335 (3): 676-682.

[5] Freckmann G., Schmid C., Baumstark A., Pleus S., Link M., Haug C. System accuracy evaluation of 43 blood glucose monitoring systems for self-monitoring of blood glucose according to DIN EN ISO 15197. J Diabetes Sci Technol. 2012 Sep 1; 6 (5):1060-1075.

RIGHTS & PERMISSIONS

Dorofeykov V.V., Androsova N.E.