Folate therapy optimization in complicated pregnancy

Gleb Olegovich Kerkeshko , Aleksandr Vartanovich Arutjunyan , Olga Nikolaevna Arzhanova , Yuliya Pavlovna Milyutina

Journal of obstetrics and women's diseases ›› 2013, Vol. 62 ›› Issue (6) : 25 -36.

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Journal of obstetrics and women's diseases ›› 2013, Vol. 62 ›› Issue (6) : 25 -36. DOI: 10.17816/JOWD62625-36
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Folate therapy optimization in complicated pregnancy

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Abstract

The role of folic acid and negative effects of its deficit in pregnancy are discussed. The folate content in the blood of pregnant women who were administered folic acid containing drugs were shown to excess the standard allowances. Possible side-effects of continuous folate blood level increase were revealed. The recommendations for folate therapy optimization in complicated pregnancy are given.

Keywords

pregnancy / folic acid / homocysteine / vitamin B12

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Gleb Olegovich Kerkeshko, Aleksandr Vartanovich Arutjunyan, Olga Nikolaevna Arzhanova, Yuliya Pavlovna Milyutina. Folate therapy optimization in complicated pregnancy. Journal of obstetrics and women's diseases, 2013, 62(6): 25-36 DOI:10.17816/JOWD62625-36

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References

[1]

Аржанова О. Н., Алябьева Е. А., Шляхтенко Т. Н. Гипергомоцистеинемия у женщин с привычным невынашиванием. Русский медицинский журнал. 2010; Т. 18 (4): 168-70.

[2]

Громова О. А., Торшин И. Ю. Наталбен-Супра витаминно-минеральный комплекс для беременных и кормящих, обогащенный омега-3 ПНЖК. Методическое пособие для врачей. М.: РСЦ Института микроэлементов ЮНЕСКО; 2012.

[3]

Громова О. А., Торшин И. Ю. Роль фолиевой кислоты и цианкобаламина в профилактике патологии беременности и пороков развития плода. Методическое пособие для врачей. М.: РСЦ Института микроэлементов ЮНЕСКО; 2012.

[4]

Громова О.А., Торшин И.Ю., Хаджидис А.К. Клинические и молекулярные аспекты эффективного и безопасного лечения анемии. М.; 2010.

[5]

Ефимов В. С., Цакалов А. К. Гомоцистеинемия в патогенезе тромбоваскулярной болезни и атеросклероза. Лабораторная медицина. 1999; № 2: 44-8.

[6]

Курцер М. А., Гродницкая Е. Э. Фолиевая кислота в реализации репродуктивной функции. Методические рекомендации для врачей. М.; 2011.

[7]

Семенова Т. В. и др. Нарушение фолатного обмена при табакокурении во время беременности. Журнал акушерства и женских болезней. 2013; Т. 62 (2): 34-42.

[8]

Шмелева В. М. Гипергомоцистеинемия в практике акушера-гинеколога. Terra Medica. 2007; № 4: 36-9.

[9]

Шмелева В. М. Роль гипергомоцистеинемии в формировании протромботических нарушений системы гемостаза. Автореф. дис… д-ра. мед. наук. СПб.; 2010.

[10]

Bailey L. B., Berry R. J. Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage. Am. J. Clin. Nutr. 2005; 81(5): 1213S-7S.

[11]

Botto L. D., Olney R. S., Erickson J. D. Vitamin supplements and the risk for congenital anomalies other than neural tube defects. Am. J. Med. Genet. C Semin. Med. Genet. 2004; 125C(1): 12-21.

[12]

Czeizel A. E. Periconceptional folic acid-containing multivitamin supplementation. Eur. J. Obstet. Gynec. Reprod. Biol. 1998; 75: 151-61.

[13]

Czeizel A. E. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. Brit. Med. J. 1993; 306: 1645-8.

[14]

Czeizel A. E. Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. Am. J. Med. Genet. 1996; 62: 179-83.

[15]

Czeizel A. E. The primary prevention of birth defects: Multivitamins or folic acid? Int. J. Med. Sci. 2004; 1(1): 50-61.

[16]

Czeizel A. E., Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 1992; 327: 1832-5.

[17]

Dolnick B. J., Cheng Y. C. Human thymidylate synthetase. II. Derivatives of pteroylmono- and -polyglutamates as substrates and inhibitors. J Biol. Chem. 1978; 253: 3563-74.

[18]

Hollis N. D. et al. Preconception folic acid supplementation and risk for chromosome 21 nondisjunction: a report from the National Down Syndrome Project. Am. J. Med. Genet. A. 2013; 161A(3): 438-44.

[19]

Jacobs E. T., Thompson P. A., Martinez M.E. Diet, gender, and colorectal neoplasia. J. Clin. Gastroenterol. 2007; 41(8): 731-46.

[20]

Jarmuła A. Antifolate inhibitors of thymidylate synthase as anticancer drugs. Mini Rev. Med. Chem. 2010; 10(13): 1211-22.

[21]

Kim Y.I. Does a high folate intake increase the risk of breast cancer? Nutr. Rev. 2006; 64(10, pt 1): 468-75.

[22]

Komatsu M., Tsukamoto I. Effect of folic acid on thymidylate synthase and thymidine kinase in regenerating rat liver after partial hepatectomy. Biochim. Biophys. Acta. 1998; 1379: 289-96.

[23]

Ly A. et al. Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring. Cancer Res. 2011; 71(3): 988-97.

[24]

Matthews R. G., Baugh C. M. Interactions of pig liver methylenetetrahydrofolate reductase with methylenetetrahydropteroylpolyglutamate substrates and with dihydropteroylpolyglutamate inhibitors. Biochemistry. 1980; 19: 2040-5.

[25]

Mikael L. G. et al. Moderately high intake of folic acid has a negative impact on mouse embryonic development. Birth Defects Res. A Clin. Mol. Teratol. 2013; 97(1): 47-52.

[26]

Miller J. W. Folic Acid. In: Caballero B. ed. Encyclopedia of Human Nutrition. 3-rd edn. N.Y.: Academic Press; 2013: 262-9.

[27]

Morris M. S. et al. Folate and vitamin B12 status in relation to anemia, macrocytosis, and cognitive impairment among older Americans in the age of folic acid fortification. Am. J. Clin. Nutr. 2007; 85: 193-200.

[28]

MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council vitamin study. Lancet. 1991; 338: 131-7.

[29]

Nijhout H. F. et al. A mathematical model of the folate cycle: new insights into folate homeostasis. J. Biol. Chem. 2004; 279(53): 55008-16.

[30]

Ohrvik V. E, Witthoft C. M. Human folate bioavailability. Nu trients. 2011; 3(4): 475-90.

[31]

Patterson D. Folate metabolism and the risk of Down syndrome. Downs Syndr. Res. Pract. 2008; 12(2): 93-7.

[32]

Roy S. et al. Effect of maternal micronutrients (folic acid and vitamin B(12)) and omega 3 fatty acids on indices of brain oxidative stress in the offspring. Brain Dev. 2013. Available at: http://www.sciencedirect.com/science/article/pii/S0387760413001307. (accessed 13.01.2014)

[33]

Roy S. et al. Maternal micronutrients (folic acid and vitamin B(12)) and omega 3 fatty acids: implications for neurodevelopmental risk in the rat offspring. Brain Dev. 2012; 34(1): 64-71.

[34]

Sable P. et al. Altered brain neurotrophins at birth: consequence of imbalance in maternal folic acid and vitamin B12 metabolism. Neuroscience. 2011; 190: 127-34.

[35]

Salerno P. et al. Folic acid and congenital malformation: scientific evidence and public health strategies. Ann. Ig. 2008; 20(6): 519-30.

[36]

Sauer J., Mason J. B., Choi S.W. Too much folate: a risk factor for cancer and cardiovascular disease? Curr. Opin. Clin. Nutr. Metab. Care. 2009; 12(1): 30-6.

[37]

Savage D. et al. Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe. Br. J. Haematol. 1994. Vol.86. P. 844-850.

[38]

Savage D. G., Lindenbaum J. Neurological complications of acquired cobalamin deficiency: clinical aspects. Baillieres Clin. Haematol. 1995; 8: 657-78.

[39]

Sharland E., Montgomery B., Granell R. Folic acid in pregnancy - is there a link with childhood asthma or wheeze? Aust. Fam. Physician. 2011; 40(6): 421-4.

[40]

Smith A. D., Kim Y. I., Refsum H. Is folic acid good for everyone? Am. J. Clin. Nutr. 2008; 87(3): 517-33.

[41]

Stolzenberg-Solomon R. Z. et al. Folate intake, alcohol use, and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial. Am. J. Clin. Nutr. 2006; 83(4): 895-04.

[42]

Tam C., O’Connor D., Koren G. Circulating unmetabolized folic acid: relationship to folate status and effect of supplementation. Obstet. Gynecol. Int. 2012; Article ID 485179.

[43]

Van Guelpen B. Folate in colorectal cancer, prostate cancer and cardiovascular disease. Scand. J. Clin. Lab. Invest. 2007; 67(5): 459-73.

[44]

Wald N. J. et al. Quantifying the effects of folic acid. Lancet. 2001; 358: 2069-73.

[45]

Wald N.J. Commentary: a brief history of folic acid in the prevention of neural tube defects. Int. J. Epidemiol. 2011. Vol. 40, N 5. P. 1154-1156.

[46]

Whitrow M. J. et al. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Am. J. Epidemiol. 2009; 170(12): 1486-93.

[47]

Yajnik C.S. et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the pune maternal nutrition study. Diabetologia. 2008; 51: 29-38.

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Kerkeshko G.O., Arutjunyan A.V., Arzhanova O.N., Milyutina Y.P.

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