Evaluation of the efficiency and safety of therapy with calcium for pregnant women with symphysiopathia

Anna Gennadyevna Dedul; Yelena Vitalyevna Mozgovaya; Tatyana Ivanovna Oparina; Gulrukhsor Khaybulloyevna Tolibova; Mariya Anatolyevna Petrosyan; Viktoriya Olegovna Polyakova

doi:10.17816/JOWD62210-16

Journal of obstetrics and women's diseases ›› 2013, Vol. 62 ›› Issue (2) : 10 -16. DOI: 10.17816/JOWD62210-16

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Evaluation of the efficiency and safety of therapy with calcium for pregnant women with symphysiopathia

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Abstract

According to the modern concepts, symphysiopathia usually occurs in the second half of pregnancy as a result of mineral metabolism violations. This complication of pregnancy mainly manifested as a pubic bone diastasis, pain in the bone of the pelvis and of the lower limbs, and cramps in the calf muscles. There are clinical manifestations of the symphysiopathia; indicators of calcium, magnesium and phosphorus in the blood and daily excretion of these minerals in the urine compared with those which have healthy pregnant women in the second and third trimesters. There is histological and immunohistochemical evaluation of placentas of patients on background treatment. The vast majority of pregnant women with symphysiopathia found increase in urinary calcium and magnesium in the urine remaining in the normal performance of mineral metabolism. According to the studies, the preparation of magnesium, calcium, and the local ultraviolet irradiation of symphysis pubis may reduce the clinical symptoms of symphysiopathia. The use of calcium supplements together with magnesium does not lead to excessive deposition of calcium salts in the placental tissue and improve metabolic function of placenta.

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symphysiopathia / levels of calcium and magnesium in blood / daily excretion of calcium and magnesium / calmodulin / CaMK II

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Anna Gennadyevna Dedul, Yelena Vitalyevna Mozgovaya, Tatyana Ivanovna Oparina, Gulrukhsor Khaybulloyevna Tolibova, Mariya Anatolyevna Petrosyan, Viktoriya Olegovna Polyakova. Evaluation of the efficiency and safety of therapy with calcium for pregnant women with symphysiopathia. Journal of obstetrics and women's diseases, 2013, 62(2): 10-16 DOI:10.17816/JOWD62210-16

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References

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[1]	Алешин С. Н. Вещества жизни: кальций, магний и витамин D. — М., 2004. — 816 с.

[2]	Громова О. А. Актуальные вопросы и перспективы применения витамина D и кальция. — М., 2011. — 48 с.

[3]	Громова О. А. Магний и пиродоксин: основы знаний. — М.: ПротоТип, 2006. — 234 с.

[4]	Княжев В. А., Суханов Б. П., Тутельян В. А. Правильное питание. Биодобавки, которые вам необходимы. — М.: ГЭОТАР Медицина,1998. — 208 с.

[5]	Кудрявцева Е. Поливитамины для беременных и кормящих женщин URL: http://www.u-mama.ru/read/article_print.php?id=3406 (дата обращения 09.11.2013).

[6]	Милованов А. П. Патология системы мать — плацента — плод. — М., 1999. — 448 с.

[7]	Савельева Г. М. Акушерство: учебник. — М.: Медицина, 2000. — 816 с.

[8]	Система кальций-кальмодулин. Взаимосвязи вторичных посредников URL: http://meduniver.com/Medical/Physiology/59.html (дата обращения 19.04.2013).

[9]	Чернуха Е. А., Ананьев Е. В. Дисфункция лонного сочленения // Журнал Российского общества акуш.-гин. — 2006. — № 3.

[10]	Brown E. M. Mutations in the calcium-sensing receptor and their clinical implications // Horm. Res. — 1997. — Vol. 48. — P. 148–199.

[11]	Fry D. Perinatal symphysis pubis dysfunction: a review of the literature // J. Assoc. Chart. Physiotherapists Womens Health. — 1999. — Vol. 85. — P. 11–18.

[12]	Grannum P. A., Berkowitz R. L., Hobbins J. C. The ultrasonic changes in the maturing placent // Am. J. Obstet. Gynecol. — 1979. — Vol. 133, N 8. — P. 915–922.

[13]	MacLennan A. H., MacLennan S. C. Norwegian Association for Women with Pelvic Girdle Relaxation. Symptom-giving pelvic girdle relaxation of pregnancy, postnatal pelvic joint syndrome and developmental dysplasia of the hip // Acta Obstet. Gynecol. Scand. — 1997. — Vol. 76. — P. 760–764.

[14]	Pharmacokinetic and pharmacodynamic comparison of two calciumsupplements in postmenopausal women / Heller H. J. [et al.] // J. Clin. Pharmacology. — 2000. — Vol. 40. — P. 1237–1244.

[15]	Symphyseal distention in relation to serum relaxin levels and pelvic pain in pregnancy / Björklund K. [et al.] // Acta Obstet. Gynecol. Scand. — 2000. — Vol. 79, N 4. — P. 269–275.

[16]	Triple pelvic ring fixation in patients with severe pregnancy — related low back and pelvic pain / Van Zwienen C. M. [et al.] //Spine. — 2004. — Vol. 29, N 4. — P. 478–484.

[17]	Ultrastructural and immunohistochemical analysis of proteoglycans in mouse public symphysis / Pinheiro M. C. [et al.] //Cell. Biol. Int. — 2003. — Vol. 27, N 8. — P. 647–655.

[18]	Young J. Relaxation of the pelvic joints in pregnancy: pelvic arthoropathy of pregnancy // J. Obstet. Gynecol. Br. Emp. — 1940. — Vol. 47, N 5. — P.493–524.