Leptin and the female reproductive system (review)

Abstract

The review presents recent data on the biological properties of leptin and its involvement in the pubertal development and pathogenesis of various forms of ovarian failure

Keywords

obesity / ovarian failure / female reproductive system / leptin

References

[1] Метаболический синдром у женщин (патофизиология и клиника) / Беляков Н. А. [и др.]. — СПб., 2005. — 440 с.

[2] Ожирение и гормональная функция яичников / Мишарина Е. В. [и др.] // Эфферентная терапия. — 2007. — Т. 13, N 1. — С. 42–45.

[3] Особенности секреции лептина у детей и подростков / Бородина О. В. [и др.] // Проблемы эндокринологии. — 2003. — Т. 49,№ 5. — С. 20–23.

[4] Панков Ю. А. Лептин в регуляции нейроэндокринной системы // Актуальные проблемы нейроэндокринологии: III Всерос. науч.практ. конф.— М., 2003.

[5] A nutrient-sensing pathway regulates leptin gene in muscle and fat / Wang J. [at al.] // Nature. — 1998. — Vol. 393. — Р. 684–688.

[6] Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor- 1alpha / Wu M.H. [et al.] // Am. J. Patho. — 2007. — Vol. 170, N 2. — P. 590–598.

[7] Acute and chronic effects of insulin on leptin production in humans — studies in vivo and in vitro / Kolaczynski J. W. [at al.] // Diabetes. — 1996. — Vol. 45. — Р. 699–701.

[8] Adipose tissue leptin production and plasma leptin kinetics in humans / Klein S. [at al.] // Diabetes. — 1996. — Vol. 45. — Р. 984–987.

[9] Ahima R. S. Revisiting leptons role in obesity and weight loss // J. Clin. Endocr. Metab. — 2008. — Vol. 118. — Р. 2380–2383.

[10] Beneficial effects of leptin on obesity, T-cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency / Farooqi I. S. [ et al.] // J. Clinical Investigation. — 2002. —Vol. 110. — P. 1093–1103.

[11] Brannian J. D., Hansen K. A. Leptin and ovarian folliculogenesis: implications for ovulation induction and ART outcomes // Semin. Reprod. Med. — 2002. — Vol. 20, N 2. — P. 103–112.

[12] Chehab F. F., Lim M. E., Li R. Correction of the sterility defect in obese female mice by treatment with the human recombinant leptin // Nat. Genet. — 1996. — Vol. 12. — Р. 318–320.

[13] Circulating leptin in women: a longitudinal studybin the menstrual cycle and during pregnancy / Hardie L. [at al.] // Clin.Endocrinol.— 1997. — Vol. 47. — Р. 101–106.

[14] Decreased soluble leptin receptor levels in women with polycystic ovary syndrome / Hahn S. [et al.] // Eur. J. Endocrinol. — 2006. — Vol. 154, N 2. — P. 287–294.

[15] Diurnal and ultradian rhythmicity of plasmа leptin: effects of gender and adiposity / Saad M. F. [ et al.] // J. Clin. Endocrin. Metab. — 1998. — Vol. 83. — P. 453–459.

[16] Effect of puberty on the relationship between circulating leptin and body composition / Horlick M.B. [at al.] // J. Clin. Endocrinol. Metab. — 2000. — Vol. 85. — Р. 2509–2518.

[17] Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty / Lebrethon M. C. [et al.] // J. Neuroendocrinol. — 2007. — Vol. 19, N 3. — P. 181–188.

[18] Effects of leptin on gonadotropin secretion in juvenile female rat pituitary cells / Tezuka M.[et al.] // Eur. J. Endocrinol. — 2002. — Vol. 146, N 2. — P. 261–266.

[19] Elevated leptin concentrations in pregnancy and lactation: possible role as a modulator of substrate utilization / Mukherjta R. [at al.] // Life Sci. — 1999. — Vol. 65. — Р. 1183–1193.

[20] Episodic leptin release is independent of luteinizing hormone secretion / Sir-Petermann T. [et al.] // Hum. Reprod. — 1999. — Vol. 14, N 11. — P. 2695–2699.

[21] Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting / Sinha M. K. [at al.] // Clin. Invest. — 1996. — Vol. 98. — Р.1277–1282.

[22] Expression of leptin receptor in human endometrium and fluctuation during the menstrual cycle / Kitawaki J. [at al.] // J. Clin. Endocrinol. Metab. — 2000. — Vol. 85. — Р. 1946–950.

[23] Expression of functional leptin receptors in rodent Leydig cells / Caprio M. [at al.] // Endocrinology. — 1999. — Vol. 140, N 49. — Р. 39–47.

[24] Folliculogenesis is impaired and granulosa cell apoptosis is increased in leptin-deficient mice / Hamm M.L. [et al.] // Biol. Reprod. — 2004. — Vol. 71, N 1. — P. 66–72.

[25] Friedman J. M. // Abstracts of 23 Meeting of the FEBS. — Basel, 1995. — p. 12.

[26] Frisch R. Body fat, puberty and fertility // Biol. Rev. — 1984. — Vol. 59. — Р. 161–188.

[27] Gh and IGF-I increase leptin receptor expression in prepubertal pig ovaries: the role of leptin in steroid secretion and cell apoptosis / Gregoraszczuk E. L. [ et al.] // Acta Vet. Hung. — 2006. — Vol. 54, N 3. — P. 413–426.

[28] Guo X., Chen S., Xing F. Effects of leptin on estradiol and progesterone production by human luteinized granulosa cells in vitro // Zhonghua Fu Chan Ke Za Zhi. — 2001. — Vol. 36, N 2. — P. 95–97.

[29] Identification and expression cloning of a leptin receptor Ob-R / Tartaglia R. A. [at al.] // Cell. — 1995. — Vol. 83. — Р. 1263–1271.

[30] Inhibitory action of leptin on early follicular growth differs in immature and adult female mice / Kikuchi N. [et al.] // Biol. Reprod. —2001. — Vol. 65, N 1. — P. 66–71.

[31] Inverse correlation between serum testosterone and leptin in men / Luukkaa V. [at al.] // J. Clin. Endocr. Metab. — 1998. —Vol. 83. — Р. 3243–3246.

[32] Kershaw E. S. Adipose tissue as an endocrine organ // J. Clin. Endocrinol. Metab. — 2004. — Vol. 89, N 6. — Р. 2548–2556.

[33] Kowalska I., Kinalski M., Wolczinski S. The influence of obesity on ovarian function. Plasma leptin concentration in women with polycystic ovary syndrome // Gynecol. Pol. — 1999. — R. 70, N 6. — S.428–432.

[34] Laughlin G. A., Yen S. S. C. Hypoleptinemia in women athlets: absence of a diurnal rhythm with amenorrhea // J. Clin. Endocrinol. Metab. — 1997. — Vol. 82. — Р. 318–321.

[35] Leibowitz S. F. Central physiological determinants of eating behavior and weigt // Eating Disorders and Obesity / eds. K. D. Brownell, C. G. Fairbum. — London, 1995. — Р. 3–7.

[36] Leptin and its receptors in human fetal and adult ovaries / Abir R. [et al ] // Fertil. Steril. — 2005. — Vol. 84, N 6. — P. 1779–1782.

[37] Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta / Hoggard N.[at al.] // Proc. Natl. Fcad. Sci. USA. — 1997. — Vol. 94. — Р. 11073–11078.

[38] Leptin and leptinbinding activity in the preovulatory follicle of polycystic ovary syndrome patients / Fedocsak P. [at al.] // Scandinavian J. Clin. Lab. Investigation. — 2000. — Vol. 60, N 8. — Р. 649–655.

[39] Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats / Almog B. [et al.] // Mol. Cell Endocrinol. — 2001. — Vol. 183, N 1–2. — P. 179–191.

[40] Leptin concentration in amniotic fluid, venous and arterial cord blood and maternal serum — high leptin synthesis in the fetus and inverse correlation with placental weight / Schubring C. [at al.] // Letter Eur. J. Pediatr. — 1996. — Vol. 155. — P. 830–834.

[41] Leptin concentration in relation to body mass index and tumor necrosis factor-alpha system in humans / Mantzoros C. S. [at al.] // J. Clin. Endocr. Metab. — 1997. — Vol. 82. — P. 3408–3413.

[42] Leptin directly stimulates aromatase activity in human luteinized granulosa cells / Kitawaki J. [et al.] // Mo. Hum. Reprod. — 1999. — Vol. 5, N 8.—P. 708–713.

[43] Leptin in reproduction / Caprio M. [at al.] // Trends Endocrinol. Metab. — 2001. — Vol. 12. — P. 62–67.

[44] Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets / Pallett A. L. [at al.] // Biochim. Biophys. Res. Commun. — 1997. — Vol. 238 — P. 267–270.

[45] Leptin is inversely related to age at menarche in human females / Matkowic V. [at al.] // J. Clin. Endocrinol. Metab. — 1997. — Vol. 82. — P. 3239–3245.

[46] Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood, relation to neonatal and placental weight / Schubring C. [at al.] // J. Clin. Endocrinol. Metab. — 1997. — Vol. 82. — P. 1480–1483.

[47] Localization of leptin receptor Mma and the long form splice variant Ob-Rb in moust hypothalamus and adolescent brain regions by in situ hybridization / Mercer J. G. [at al.] // Febslett. — 1996. — Vol. 387. — P. 113–116.

[48] Mantzoros C. S. Leptin and the hypothalamus: neuroendocrint regulation of food intake // Mol. Psychiatry. — 1999. — Vol. 4. — P. 8–12.

[49] Mantzoros C. S., Dunaif A., Flier J. S. Leptin concentrations in the polycystic ovary syndrome // J. Clin. Endocrinol. Metab. — 1999. — Vol. 82, N 6. — P. 1687–1691.

[50] Mantzoros C. S., Flier J. S., Rogol A. R. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. Rising leptin levels may signal the onset of puberty //J. Clin.Endocrinol. Metab. — 1997. — Vol. 82. — P. 1066–1070.

[51] Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects / Sinha M. K. [at al.] // J. Clin. Invest. — 1996. — Vol. 97. — P. 1344–1347.

[52] Nonadipose tissue production of leptin, leptin as a novel placenta — derived hormone in humans / Masuzaki H. [at al.] // Nat. Med. — 1997. — Vol. 3. — P. 1029–1033.

[53] Oestradiol plus progesterone treatment increases serum leptin concentrations in normal women / Ioannis E. Messinis [et al] // Oxford J. Medicine Human Reproduction. — 2001. — Vol. 16.— P. 1827–1832.

[54] Panday S., Maheshwari A., Bhattacharya S. The impact of female on the outcome of fertility treatment // J. Hum. Reprod. Sci. — 2010. — Vol. 32. — P. 62–67.

[55] Positional cloning of the mouse obese gene and its human homologue / Zhang Y. [at al.] // Nature. — 1994. — Vol. 372. — P. 425–432.

[56] Prena U., Rehan H.S., Vikas Seth. Serum leptin changes with metformin treatment in polycystic ovarian syndrome, correlation with ovulation, insulin and testosterone levels // EXCLI Journal. — 2011. — Vol. 10. — P. 9–15.

[57] Role of brain insulin receptor in control of body weight and reproduction / Bruning J. C. [at al.] // Science. — 2000. — Vol. 289. — P. 2122–2125.

[58] Serum immunoreactive — leptin concentrations in normal-weight and obese humans / Considine R.V. [at al.] // N. Engl. J. Med. — 1996. — Vol. 334. — P. 292–295.

[59] Simultaneous increases of leptin and gonadotropin-releasing hormone following exogenous estrogen administration in women with normally menstrual cycle / Lin K. C. [ et al.] // Endocrinol. J. — 2005. — Vol. 52, N 4. — P. 449–454.

[60] Spicer J. L., Francisco C. C. Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis // Biol. Reprod. — 1998. — Vol. 58. — P. 207–212.

[61] Study of effects of leptin on cultured human luteinized granulosa cell function / Huang H. [et al.] // Zhonghua Fu Chan Ke Za Zhi. — 2002. — Vol. 37, N 3. — P. 152–154.

[62] The effects of ovarian steroids, epidermal growth factor, insulin and insulin-like growth factor-1 on ovarian stromal growth / Franks S. [et al.] // Proceeding of the Endocrine Society, 79- th Annual Meeting, June 11–14, 1997. — San Diego: Endocr. Soc Pres, 1997. — P. 389.

[63] The endometrium as a novel target for leptin: differences in fertility and subfertility / Alfer J. [at al.] // J. Clin. Endocrinol. Metab. — 1997. — Vol. 82. — P. 3408–3413.

[64] The endometrium as a novel target for leptin: differences in fertility and subfertility / Alfer J. [et al.] // Mol. Hum. Reprod. — 2000. — Vol. 6, N 7. — P. 595–601.

[65] The stomach in a source of leptin / Bado A. [at al.] // Nature. — 1998. — Vol. 394. — P. 790–793.

[66] Vogel G. Leptin: a trigger for puberty? // Science. — 1996. — Vol. 274. —P. 1466–1467.

[67] Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment / Clark A.M. [et al.] // Hum. Reprod . — 1998. — Vol. 13. — P. 1502–1505.

[68] Zachow R. J., Magoffin D. A. Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells // Endocrinology. — 1997. —Vol. 138. — Р. 847–850.

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Ryazantseva E.M.