Noninvasive prenatal diagnostic. Problems, approaches and perspectives

Abstract

In the review possibilities of noninvasive prenatal diagnostics on DNA of a fetus circulating in peripheral blood of pregnant woman are discussed. Characteristics cell-free (cf) DNA of plasma and fetus cfDNA (cffNA), circulating in a parent blood-groove are resulted. Methodical approaches to extraction and analysis cffDNA are considered. Possibilities and restrictions of application of a method for fetal sexing and fetal Rhesus factor detection, and also prospect of noninvasive diagnostics of the most frequent aneuploidies are discussed

Keywords

noninvasive prenatal diagnostic / cell free fetal DNA / fetal sexing / fetal rhesus / prenatal diagnostic of aneuploidies

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RIGHTS & PERMISSIONS

Malysheva O.V., Baranov V.S.