Towards gene therapy of endometriosis
Anastasia Nikolaevna Shubina , Anton Vyacheslavovich Kiselev , Anna Alexeevna Egorova , Vladislav Sergeevich Baranov
Journal of obstetrics and women's diseases ›› 2012, Vol. 61 ›› Issue (3) : 148 -158.
Towards gene therapy of endometriosis
Review of current state and future prospects of endometriosis gene therapy is presented. Main molecular pathogenetic mechanisms and possible ways of their correction by means of genetic constructs are described. Examples of anti-estrogenic, anti-angiogenic, suicidal gene therapy approaches are presented. Advantages of siRNA and microRNA mediated regulation of endometrial genes expression are discussed
endometriosis / gene therapy / genetic constructs / siRNA / microRNA / angiogenesis
Shubina A.N., Kiselev A.V., Egorova A.A., Baranov V.S.
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