Features of the gene polymorphism of estrogen and progesterone receptors in women with uterine leiomyoma
Natalya Sergeevna Osinovskaya , Tatyana Eduardovna Ivaschenko , Lyailya Kharryasovna Dzhemlikhanova , Vladislav Sergeevich Baranov , Antonina Nicolaevna Tkachenko , Iskender Yuryevich Sultanov
Journal of obstetrics and women's diseases ›› 2012, Vol. 61 ›› Issue (3) : 109 -114.
Features of the gene polymorphism of estrogen and progesterone receptors in women with uterine leiomyoma
Uterine Leiomyoma (Leiomyoma) (LM) — benign and most common (incidence 20–45 %) hormone-dependent tumors of female genital organs. Comparative analysis of frequencies of polymorphic variants of genes of estrogen receptor (ERα) and progesterone receptor (PGR) in patients with LM and the population samples was conducted in this work. Also it was investigated their association with clinical manifestation of hyperplastic processes of the female reproductive system. It was founded that the development of LM are not associated with individual polymorphic variants of genes of estrogen receptor and progesterone receptor. This fact does not include their participation in the development of proliferative and hyperplastic processes of the myometrium
ERα / PGR / leiomyoma / hormone receptors / estrogene, progesterone / ERα / PGR
Osinovskaya N.S., Ivaschenko T.E., Dzhemlikhanova L.K., Baranov V.S., Tkachenko A.N., Sultanov I.Y.
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