Recurrent genital endometriosis: risk factors and possible prevention strategy

Abstract

Endometriosis is one of the most common gynecological diseases in women of reproductive age, which is characterized by a relapsing course. The recurrence rate varies greatly among literary sources. This review covers symptoms and types of endometriosis, laboratory tests, options for hormonal therapy, as well as features of surgical approaches that may be associated with the disease recurrence risk. The aim of this article was to analyze and summarize current literature on the definition of endometriosis recurrence, risk factors and prevention strategy. Despite advances in the study of various mechanisms for the development of endometriosis and the use of combined treatment, a high recurrence rate remains an unsolved problem for this disease. All of this underscores the need to develop new methods for early diagnosis and treatment, taking into account the risk group and a personalized approach.

Keywords

endometriosis / recurrence / risk factors

References

[1] Rossiyskoe obshchestvo akusherov ginekologov (ROAG). Endometrioz. Klinicheskie rekomendatsii. 2020. (In Russ.) [cited 2023 Jan 16]. Available from: https://roag-portal.ru/recommendations_gynecology

[2] Российское общество акушеров гинекологов (РОАГ). Эндометриоз. Клинические рекомендаци. 2020 [дата обращения 16.01.2023.]. Доступ по ссылке: https://roag-portal.ru/ recommendations_gynecology

[3] Medikamentoznaya terapiya genital’nogo endometrioza: realii i perspektivy: rukovodstvo dlya vrachey. Ed. by M.I. Yarmolinskaya. Moscow: GEOTAR-Media; 2021. (In Russ.) DOI: 10.33029/9704-6034-4-MET-2021-1-384

[4] Медикаментозная терапия генитального эндометриоза: реалии и перспективы: руководство для врачей / под ред. М.И. Ярмолинской. Москва: ГЭОТАР-Медиа, 2021. DOI: 10.33029/9704-6034-4-МЕТ-2021-1-384

[5] Horne A, Missmer S. Pathophysiology, diagnosis, and management of endometriosis. BMJ. 2022;379. DOI: 10.1136/bmj-2022-070750

[6] Horne A., Missmer S. Pathophysiology, diagnosis, and management of endometriosis // BMJ. 2022. Vol. 379. DOI: 10.1136/bmj-2022-070750

[7] Chen I, Veth VB, Choudhry AJ, et al. Pre- and postsurgical medical therapy for endometriosis surgery. Cochrane Database Syst Rev. 2020;11(11). DOI: 10.1002/14651858.CD003678.pub3

[8] Chen I., Veth V.B., Choudhry A.J., et al. Pre- and postsurgical medical therapy for endometriosis surgery // Cochrane Database Syst. Rev. 2020. Vol. 11. No. 11. DOI: 10.1002/14651858.CD003678.pub3

[9] Sasamoto N, Ngo L, Vitonis AF, et al. Circulating proteomic profiles associated with endometriosis in adolescents and young adults. Hum Reprod. 2022;37(9):2042–2053. DOI: 10.1093/humrep/deac146

[10] Sasamoto N., Ngo L., Vitonis A.F., et al. Circulating proteomic profiles associated with endometriosis in adolescents and young adults // Hum. Reprod. 2022. Vol. 37. No. 9. P. 2042–2053. DOI: 10.1093/humrep/deac146

[11] Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med. 2020;382:1244–1256. DOI: 10.1056/nejmra1810764

[12] Zondervan K.T., Becker C.M., Missmer S.A. Endometriosis // N. Engl. J. Med. 2020. Vol. 382. P. 1244–1256. DOI: 10.1056/nejmra1810764

[13] Marchandot B, Curtiaud A, Matsushita K, et al. Endometriosis and cardiovascular disease. Eur Heart J Open. 2022;2(1). DOI: 10.1093/ehjopen/oeac001

[14] Marchandot B., Curtiaud A., Matsushita, K. et al. Endometriosis and cardiovascular disease // Eur. Heart J. Open. 2022. Vol. 2. No. 1. DOI: 10.1093/ehjopen/oeac001

[15] Ceccaroni M, Bounous VE, Clarizia R, et al. Recurrent endometriosis: a battle against an unknown enemy. Eur J Contracept Reprod Health Care. 2019;24(6):464–474. DOI: 10.1080/13625187.2019.1662391

[16] Ceccaroni M., Bounous V.E., Clarizia R., et al. Recurrent endometriosis: a battle against an unknown enemy // Eur. J. Contracept. Reprod. Health Care. 2019. Vol. 24. No. 6. P. 464–474. DOI: 10.1080/13625187.2019.1662391

[17] Aylamazyan EK, Yarmolinskaya MI. Molotkov AS, et al. Classifications of endometriosis. Journal of Obstetrics and Women’s Diseases. 2017;66(2):77–92. (In Russ.) DOI: 10.1016/10.17816/JOWD66277-92

[18] Айламазян Э.К., Ярмолинская М.И., Молотков А.С., и др. Классификации эндометриоза // Журнал акушерства и женских болезней. 2017. Т. 66. № 2. С. 77–92. DOI: 10.1016/10.17816/JOWD66277-92

[19] Nirgianakis K, Ma L, McKinnon B, et al. Recurrence patterns after surgery in patients with different endometriosis subtypes: a long-term hospital-based cohort study. J Clin Med. 2020;9(2):496. DOI: 10.3390/jcm9020496

[20] Nirgianakis K., Ma L., McKinnon B., et al. Recurrence patterns after surgery in patients with different endometriosis subtypes: a long-term hospital-based cohort study // J. Clin. Med. 2020. Vol. 9. No. 2. P. 496. DOI: 10.3390/jcm9020496

[21] Selçuk I., Bozdağ G. Recurrence of endometriosis; risk factors, mechanisms and biomarkers; review of the literature. J Turk Ger Gynecol Assoc. 2013;14(2):98–103. DOI: 10.5152/jtgga.2013.52385

[22] Selçuk I., Bozdağ G. Recurrence of endometriosis; risk factors, mechanisms and biomarkers; review of the literature // J. Turk. Ger. Gynecol. Assoc. 2013. Vol. 14. No. 2. P. 98–103. DOI: 10.5152/jtgga.2013.52385

[23] Dückelmann AM, Taube E, Abesadze E, et al. When and how should peritoneal endometriosis be operated on in order to improve fertility rates and symptoms? The experience and outcomes of nearly 100 cases. Arch Gynecol Obstet. 2021;304(1):143–155. DOI: 10.1007/s00404-021-05971-6

[24] Dückelmann A.M., Taube E., Abesadze E., et al. When and how should peritoneal endometriosis be operated on in order to improve fertility rates and symptoms? The experience and outcomes of nearly 100 cases // Arch. Gynecol. Obstet. 2021. Vol. 304. No. 1. P. 143–155. DOI: 10.1007/s00404-021-05971-6

[25] Gubbels AL, Li R, Kreher D, et al. Prevalence of occult microscopic endometriosis in clinically negative peritoneum during laparoscopy for chronic pelvic pain. Int J Gynaecol Obstet. 2020;151(2):260–266. DOI: 10.1002/ijgo.13303

[26] Gubbels A.L., Li R., Kreher D., et al. Prevalence of occult microscopic endometriosis in clinically negative peritoneum during laparoscopy for chronic pelvic pain // Int. J. Gynaecol. Obstet. 2020. Vol. 151. No. 2. P. 260–266. DOI: 10.1002/ijgo.13303

[27] Li XY, Chao XP, Leng JH, et al. Risk factors for postoperative recurrence of ovarian endometriosis: long-term follow-up of 358 women. J Ovarian Res. 2019;12(1):79. DOI: 10.1186/s13048-019-0552-y

[28] Li X.Y., Chao X.P., Leng J.H., et al. Risk factors for postoperative recurrence of ovarian endometriosis: long-term follow-up of 358 women // J. Ovarian. Res. 2019. Vol. 12. No. 1. P. 79. DOI: 10.1186/s13048-019-0552-y

[29] Lee SY, Kim ML, Seong SJ, et al. Recurrence of ovarian endometrioma in adolescents after conservative, laparoscopic cyst enucleation. J Pediatr Adolesc Gynecol. 2017;30(2):228–233. DOI: 10.1016/j.jpag.2015.11.001

[30] Lee S.Y., Kim M.L., Seong S.J., et al. Recurrence of ovarian endometrioma in adolescents after conservative, laparoscopic cyst enucleation // J. Pediatr. Adolesc. Gynecol. 2017. Vol. 30. No. 2. P. 228–233. DOI: 10.1016/j.jpag.2015.11.001

[31] Somigliana E, Viganò P, Benaglia L, et al. Ovarian stimulation and endometriosis progression or recurrence: a systematic review. Reprod Biomed Online. 2019;38(2):185–194. DOI: 10.1016/j.rbmo.2018.11.021

[32] Somigliana E., Viganò P., Benaglia L., et al Ovarian stimulation and endometriosis progression or recurrence: a systematic review // Reprod. Biomed. Online. 2019. Vol. 38. No. 2. P. 185–194. DOI: 10.1016/j.rbmo.2018.11.021

[33] ESHRE Endometriosis Guideline Development Group. Endometriosis. Guideline of European Society of Human Reproduction and Embryology. 2022 [cited 2023 Jan 16]. Available from: https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Endometriosis-guideline

[34] ESHRE Endometriosis Guideline Development Group. Endometriosis. Guideline of European Society of Human Reproduction and Embryology. 2022 [дата обращения 16.01.2023]. Доступ по ссылке: https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Endometriosis-guideline

[35] Selcuk S, Cam C, Koc N, et al. Evaluation of risk factors for the recurrence of ovarian endometriomas. Eur J Obstet Gynecol Reprod Biol. 2016;203:56–60. DOI: 10.1016/j.ejogrb.2016.05.008

[36] Selcuk S., Cam C., Koc N., et al. Evaluation of risk factors for the recurrence of ovarian endometriomas // Eur. J. Obstet. Gynecol. Reprod. Biol. 2016. Vol. 203. P. 56–60. DOI: 10.1016/j.ejogrb.2016.05.008

[37] Nezhat C, Hajhosseini B, King LP. Laparoscopic management of bowel endometriosis: predictors of severe disease and recurrence. JSLS. 2011;15(4):431–438. DOI: 10.4293/108680811x13176785203752

[38] Nezhat C., Hajhosseini B., King L.P. Laparoscopic management of bowel endometriosis: predictors of severe disease and recurrence // JSLS. 2011. Vol. 15. No. 4. P. 431–438. DOI: 10.4293/108680811x13176785203752

[39] Aarestrup J, Jensen BW, Ulrich LG, et al. Birth weight, childhood body mass index and height and risks of endometriosis and adenomyosis. Ann Hum Biol. 2020;47(2):173–180. DOI: 10.1080/03014460.2020.1727011

[40] Aarestrup J., Jensen B.W., Ulrich L.G., et al. Birth weight, childhood body mass index and height and risks of endometriosis and adenomyosis // Ann. Hum. Biol. 2020. Vol. 47. No. 2. P. 173–180. DOI: 10.1080/03014460.2020.1727011

[41] Shah DK, Correia KF, Vitonis AF, et al. Body size and endometriosis: results from 20 years of follow-up within the Nurses’ Health Study II prospective cohort. Hum Reprodn. 2013;28(7):1783–1792. DOI: 10.1093/humrep/det120

[42] Shah D.K., Correia K.F., Vitonis A.F., et al. Body size and endometriosis: results from 20 years of follow-up within the Nurses’ Health Study II prospective cohort // Hum. Reprod. 2013. Vol. 28. No. 7. P. 1783–1792. DOI: 10.1093/humrep/det120

[43] Tobiume T, Kotani Y, Takaya H, et al. Determinant factors of postoperative recurrence of endometriosis: difference between endometrioma and pain. Eur J Obstet Gynecol Reprod Biol. 2016;205:54–59. DOI: 10.1016/j.ejogrb.2016.07.516

[44] Tobiume T., Kotani Y., Takaya H., et al. Determinant factors of postoperative recurrence of endometriosis: difference between endometrioma and pain // Eur. J. Obstet. Gynecol. Reprod. Biol. 2016. Vol. 205. P. 54–59. DOI: 10.1016/j.ejogrb.2016.07.516

[45] Gu Z, Li X, Shi J, et al. The development of predictive nomogram of recurrence for patients with endometrioma after cystectomy who were younger than 45 years old and received postoperative therapy. Front Med (Lausanne). 2022;9:872481. DOI: 10.3389/fmed.2022.872481

[46] Gu Z., Li X., Shi J., et al. The development of predictive nomogram of recurrence for patients with endometrioma after cystectomy who were younger than 45 years old and received postoperative therapy // Front. Med. 2022. Vol. 9. P. 872481. DOI: 10.3389/fmed.2022.872481

[47] Yarmolinskaya MI, Semenova VO, Beganova AK. Molecular biological profile of the endometrium in patients with endometriosis (literature review). Russian Journal of Human Reproduction. 2022;28(3):54–65. (In Russ.) DOI: 10.17116/repro20222803154

[48] Ярмолинская М.И., Семенова В.О., Беганова А.К. Молекулярно-биологический профиль эндометрия при наружном генитальном эндометриозе (обзор литературы) // Проблемы репродукции. 2022. Т. 28. № 3. С. 54–65. DOI: 10.17116/repro20222803154

[49] Xu X, Chen Y, Yu Q, et al. The presence of living endometrial cells in ovarian endometriotic cyst fluid may contribute to the recurrence of endometriosis after surgical excision of endometriomas. J Ovarian Res. 2022;15(1):89. DOI: 10.1186/s13048-022-01018-9

[50] Xu X., Chen Y., Yu Q., et al. The presence of living endometrial cells in ovarian endometriotic cyst fluid may contribute to the recurrence of endometriosis after surgical excision of endometriomas // J. Ovarian. Res. 2022. Vol. 15. No. 1. P. 89. DOI: 10.1186/s13048-022-01018-9

[51] Yarmolinskaya MI, Adamyan LV. Hormonal contraceptives and endometriosis: modern view on the problem. Russian Journal of Human Reproduction. 2020;26(3):39–45. (In Russ.) DOI: 10.17116/repro20202603139

[52] Ярмолинская М.И., Адамян Л.В. Гормональные контрацептивы и эндометриоз: современный взгляд на проблему // Проблемы репродукции. 2020. Т. 26. № 3. С. 39–45. DOI: 10.17116/repro20202603139

[53] Zakhari A, Delpero E, McKeown S, et al. Endometriosis recurrence following post-operative hormonal suppression: a systematic review and meta-analysis. Hum Reprod Update. 2021:27(1):96–107. DOI: 10.1093/humupd/dmaa033

[54] Zakhari A., Delpero E., McKeown S., et al. Endometriosis recurrence following post-operative hormonal suppression: a systematic review and meta-analysis // Hum. Reprod. Update. 2021. Vol. 27. No. 1. P. 96–107. DOI: 10.1093/humupd/dmaa033

[55] Wattanayingcharoenchai R, Rattanasiri S, Charakorn C, et al. Postoperative hormonal treatment for prevention of endometrioma recurrence after ovarian cystectomy: a systematic review and network meta-analysis. BJOG. 2021;128(1):25–35. DOI: 10.1111/1471-0528.16366

[56] Wattanayingcharoenchai R., Rattanasiri S., Charakorn C., et al. Postoperative hormonal treatment for prevention of endometrioma recurrence after ovarian cystectomy: a systematic review and network meta-analysis // BJOG. 2021. Vol. 128. No. 1. P. 25–35. DOI: 10.1111/1471-0528.16366

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