High activity of MMP-2 and MMP-9 in trophoblast tissue during spontaneous abortion
P. Skorupski , M. Bogusiewicz , M. Gogacz , M. Jerzak , G. Polak , J. Tomaszewski , T. Rechberger
Journal of obstetrics and women's diseases ›› 1999, Vol. 48 ›› Issue (5S) : 151 -151.
High activity of MMP-2 and MMP-9 in trophoblast tissue during spontaneous abortion
Objective: Extracellular matrix degrading enzymes — matrix metalloproteinases are responsible for many aspects of tissue remodelling. Both matrix metalloproteinase type 2 (MMP-2) and matrix metalloproteinase type 9 (MMP-9) are involved in human implantation and placentation. These enzymes play a crucial role in some pathological processes occurring in the early pregnancy. Low activity of MMP-2 and MMP-9 during trophoblast invasion could lead to the development of preeclamsia. Also, the process of spontaneous abortion may be mediated by increased activity of MMP-2 and MMP-9.
MMP-2 / MMP-9 / trophoblast tissue / spontaneous abortion
Eсо-Vector
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