Topical issues of surgical treatment of pelvic floor dysfunction. A literature review

Abstract

This article presents a review of the current literature on the problem of omission and prolapse of the internal genitalia in women. Patients diagnosed with pelvic organ prolapse need pelvic floor plastic surgery. Currently, in spite of the extensive experience in managing this category of patients, there is still no single and unambiguous approach to the choice of surgical treatment tactics.

This review describes the latest information on the etiopathogenesis of pelvic floor supporting apparatus lesions, namely, systemic connective tissue dysplasia as the main development factor. Prospective development of genetic and immunohistochemical marker diagnosis is the key to individual selection of treatment options for this multidisciplinary problem. The results of interventions are characterized by extreme variability in terms of both effectiveness and the frequency of intra- and postoperative complications. The treatment of rare forms of prolapse after surgery for rectal cancer also raises many questions. The current multitude of types of surgical interventions for genital prolapse and variants of pelvic floor defect closure is constantly being modified. To date, there is no universal treatment option, and all available techniques have both advantages and disadvantages, as well as limited application due to the risk of somatic complications, high recurrence rate, and the need for expensive equipment and a highly qualified surgeon.

New research is needed, taking into account the current knowledge about the cellular and molecular mechanism of the lesion of the pelvic floor supporting apparatus. All of this will improve the methods of correction of pelvic organ prolapse in both typical and rare forms caused by iatrogenic factors. As a result, this may lead to an improvement in the quality of life of such patients.

Keywords

vaginal hysterectomy / pelvic organ prolapse / stress urinary incontinence / mesh implant / abdominoperineal resection

References

[1] Samuelsson EC, Victor FT, Tibblin G, et al. Signs of genital prolapse in a Swedish population of women 20 to 59 years of age and possible related factors. Am J Obstet Gynecol. 1999;180(2):299–305. DOI: 10.1016/s0002-9378(99)70203-6

[2] Samuelsson E.C., Victor F.T., Tibblin G., et al. Signs of genital prolapse in a Swedish population of women 20 to 59 years of age and possible related factors // Am. J. Obstet. Gynecol. 1999. Vol. 180. No. 2. P. 299–305. DOI: 10.1016/s0002-9378(99)70203-6

[3] Samuelsson EC, Victor FT, Svärdsudd KF. Five-year incidence and remission rates of female urinary incontinence in a Swedish population less than 65 years old. Am J Obstet Gynecol. 2000;183(3):568–574. DOI: 10.1067/mob.[phone]

[4] Samuelsson E.C., Victor F.T., Svärdsudd K.F. Five-year incidence and remission rates of female urinary incontinence in a Swedish population less than 65 years old // Am. J. Obstet. Gynecol. 2000. Vol. 183. No. 3. P.568–574. DOI: 10.1067/mob.[phone]

[5] Nygaard I, Barber MD, Burgio KL, et al.; Pelvic floor disorders network. Prevalence of symptomatic pelvic floor disorders in US women. JAMA. 2008;300(11):1311–1316. DOI: 10.1001/jama.300.11.1311

[6] Nygaard I., Barber M.D., Burgio K.L., et al.; Pelvic floor disorders network. Prevalence of symptomatic pelvic floor disorders in US women // JAMA. 2008. Vol. 300. No. 11. P. 1311–1316. DOI: 10.1001/jama.300.11.1311

[7] Walker GJ, Gunasekera P. Pelvic organ prolapse and incontinence in developing countries: review of prevalence and risk factors. Int Urogynecol J. 2011;22(2):127–135. DOI: 10.1007/s00192-010-1215-0

[8] Walker G.J., Gunasekera P. Pelvic organ prolapse and incontinence in developing countries: review of prevalence and risk factors // Int. Urogynecol. J. 2011. Vol. 22. No. 2. P. 127–135. DOI: 10.1007/s00192-010-1215-0

[9] Stadnicka G, Łepecka-Klusek C, Pilewska-Kozak A, et al. Psychosocial problems of women with stress urinary incontinence. Ann Agric Environ Med. 2015;22(3):499–503. DOI: 10.5604/12321966.1167723

[10] Stadnicka G., Łepecka-Klusek C., Pilewska-Kozak A., et al. Psychosocial problems of women with stress urinary incontinence // Ann. Agric. Environ. Med. 2015. Vol. 22. No. 3. P. 499–503. DOI: 10.5604/12321966.1167723

[11] Laganà AS, La Rosa VL, Rapisarda AMC, et al. Pelvic organ prolapse: the impact on quality of life and psychological well-being. J Psychosom Obstet Gynaecol. 2018;39(2):164–166. DOI: 10.1080/0167482X.2017.1294155

[12] Laganà A.S., La Rosa V.L., Rapisarda A.M.C., et al. Pelvic organ prolapse: the impact on quality of life and psychological well-being // J. Psychosom. Obstet. Gynaecol. 2018. Vol. 39. No. 2. P. 164–166. DOI: 10.1080/0167482X.2017.1294155

[13] Chong EC, Khan AA, Anger JT. The financial burden of stress urinary incontinence among women in the United States. Curr Urol Rep. 2011;12(5):358–362. DOI: 10.1007/s11934-011-0209-x

[14] Chong E.C., Khan A.A., Anger J.T. The financial burden of stress urinary incontinence among women in the United States // Curr. Urol. Rep. 2011. Vol. 12. No. 5. P. 358–362. DOI: 10.1007/s11934-011-0209-x

[15] Wu JM, Vaughan CP, Goode PS, et al. Prevalence and trends of symptomatic pelvic floor disorders in U.S. women. Obstet Gynecol. 2014;123(1):141–148. DOI: 10.1097/AOG.0000000000000057

[16] Wu J.M., Vaughan C.P., Goode P.S., et al. Prevalence and trends of symptomatic pelvic floor disorders in U.S. women // Obstet. Gynecol. 2014. Vol. 123. No. 1. P. 141–148. DOI: 10.1097/AOG.0000000000000057

[17] Luber KM, Boero S, Choe JY. The demographics of pelvic floor disorders: current observations and future projections. Am J Obstet Gynecol. 2001;184(7):1496–1501. DOI: 10.1067/mob.[phone]

[18] Luber K.M., Boero S., Choe J.Y. The demographics of pelvic floor disorders: current observations and future projections // Am. J. Obstet. Gynecol. 2001. Vol. 184. No. 7. P. 1496–1501. DOI: 10.1067/mob.[phone]

[19] Shah AD, Kohli N, Rajan SS, et al. The age distribution, rates, and types of surgery for pelvic organ prolapse in the USA. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(3):421–428. DOI: 10.1007/s00192-007-0457-y

[20] Shah A.D., Kohli N., Rajan S.S., et al. The age distribution, rates, and types of surgery for pelvic organ prolapse in the USA // Int. Urogynecol. J. Pelvic Floor Dysfunct. 2008. Vol. 19. No. 3. P. 421–428. DOI: 10.1007/s00192-007-0457-y

[21] Subramanian D, Szwarcensztein K, Mauskopf JA, et al. Rate, type, and cost of pelvic organ prolapse surgery in Germany, France, and England. Eur J Obstet Gynecol Reprod Biol. 2009;144(2):177–181. DOI: 10.1016/j.ejogrb.2009.03.004

[22] Subramanian D., Szwarcensztein K., Mauskopf J.A., et al. Rate, type, and cost of pelvic organ prolapse surgery in Germany, France, and England // Eur. J. Obstet. Gynecol. Reprod. Biol. 2009. Vol. 144. No. 2. P. 177–181. DOI: 10.1016/j.ejogrb.2009.03.004

[23] Wu JM, Hundley AF, Fulton RG, et al. Forecasting the prevalence of pelvic floor disorders in U.S. Women: 2010 to 2050. Obstet Gynecol. 2009;114(6):1278–1283. DOI: 10.1097/AOG.0b013e3181c2ce96

[24] Wu J.M., Hundley A.F., Fulton R.G., et al. Forecasting the prevalence of pelvic floor disorders in U.S. Women: 2010 to 2050 // Obstet. Gynecol. 2009. Vol. 114. No. 1278–1283. DOI: 10.1097/AOG.0b013e3181c2ce96

[25] Aylamazyan EK, Tsvelev YuV, Belyayeva TV, et al. Akushery-ginekologi Sankt-Peterburga (nauka v litsakh). 1703-2003. Saint Petersburg: N-L; 2003. (In Russ.)

[26] Айламазян Э.К., Цвелев Ю.В., Беляева Т.В., и др. Акушеры-гинекологи Санкт-Петербурга (наука в лицах). 1703–2003. Санкт-Петербург: Изд-во Н-Л, 2003.

[27] Ott D.O. Operativnaya ginekologiya. Saint Petersburg; 1914. (In Russ.)

[28] Отт Д.О. Оперативная гинекология. Санкт-Петербург, 1914.

[29] Aylamazyan EK, Tsvelev YuV, Repina MA. Dmitriy Oskarovich Ott. Sluzheniye Otechestvu i meditsine. Saint Petersburg: N-L; 2007. (In Russ.)

[30] Айламазян Э.К., Цвелев Ю.В., Репина М.А. Дмитрий Оскарович Отт. Служение Отечеству и медицине. Санкт-Петербург: Изд-во Н-Л, 2007.

[31] Weber AM, Walters MD. Anterior vaginal prolapse: review of anatomy and techniques of surgical repair. Obstet Gynecol. 1997;89(2):311–318. DOI: 10.1016/S0029-7844(96)00322-5

[32] Weber A.M., Walters M.D. Anterior vaginal prolapse: review of anatomy and techniques of surgical repair // Obstet. Gynecol. 1997. Vol. 89. No. 2. P. 311–318. DOI: 10.1016/S0029-7844(96)00322-5

[33] Lensen EJ, Stoutjesdijk JA, Withagen MI, et al. Technique of anterior colporrhaphy: a Dutch evaluation. Int Urogynecol J. 2011;22(5):557–561. DOI: 10.1007/s00192-010-1353-4

[34] Lensen E.J., Stoutjesdijk J.A., Withagen M.I., et al. Technique of anterior colporrhaphy: a Dutch evaluation // Int. Urogynecol. J. 2011. Vol. 22. No. 5. P. 557–561. DOI: 10.1007/s00192-010-1353-4

[35] Buyanova SN, Savel’yev SV, Grishin VL, et al. Nekotor·yye aspekty patogeneza prolapsa genitaliy. Obstetrics and Gynecology. 2001;(3):39–41. (In Russ.)

[36] Буянова С.Н., Савельев С.В., Гришин В.Л., и др. Некоторые аспекты патогенеза пролапса гениталий // Акушерство и гинекология. 2001. № 3. С. 39–41.

[37] Kostuchek DF, Gordeladze AS, Klukovkina AS. The questions of pathogenesis of uterine cervix elongation (clinical-morphological and immunohistochemical investigation). Journal of Obstetrics and Women’s Diseases. 2005;54(3):5–11. (In Russ.)

[38] Костючек Д.Ф., Горделадзе А.С., Клюковкина А.С. Вопросы патогенеза элонгации шейки матки (клинико-морфологическое и иммуногистохимическое исследование матки) // Журнал акушерства и женских болезней. 2005. Т. 54. № 3. С. 5–11.

[39] Еvseev АА, Krasnova IA, Aksenova VB, et al. Assessment of the effectiveness of surgical treatment of pelvic organ prolapse using mesh implants. Voprosy ginekologii, akusherstva i perinatologii. 2019;18(5):13–21. (In Russ.) DOI: 10.20953/1726-1678-2019-5-13-21

[40] Евсеев А.А., Краснова И.А., Аксёнова В.Б., и др. Оценка эффективности хирургического лечения пролапса тазовых органов с помощью сетчатых имплантатов // Вопросы гинекологии, акушерства и перинатологии. 2019. Т. 18. № 5. С. 13–21. DOI: 10.20953/1726-1678-2019-5-13-21

[41] Smol’nova TYu, Buyanova SN, Savel’yev SV, et al. Displaziya soyedinitel’noy tkani kak odna iz vozmozhnykh prichin nederzhaniya mochi u zhenshchin s prolapsom genitaliy. Urologiya. 2001;(2):25–30. (In Russ.)

[42] Смольнова Т.Ю., Буянова С.Н., Савельев С.В., и др. Дисплазия соединительной ткани как одна из возможных причин недержания мочи у женщин с пролапсом гениталий // Урология. 2001. № 2. С. 25–30.

[43] Makarov OV, Smetnik VP, Dobrokhotova YuE. Sindrom postgister·ektomii. Moscow; 2000. (In Russ.)

[44] Макаров О.В., Сметник В.П., Доброхотова Ю.Э. Синдром постгистерэктомии. Москва, 2000.

[45] Bezhenar VF, Palastin PM, Dery EK, et al. Role of connective tissue dysfunction markers in surgical treatment of pelvic prolapse. Effektivnaya farmakoterapiya. 2020; 16(22):24–28. (In Russ.) DOI: 10.33978/2307-3586-2020-16-22-24-28

[46] Беженарь В.Ф., Паластин П.М., Дерий Э.К. и др. Роль маркеров дисфункции соединительной ткани в хирургическом лечении пролапса тазовых органов // Эффективная фармакотерапия. 2020. Т. 16. № 22. С. 24–28. DOI: 10.33978/2307-3586-2020-16-22-24-28

[47] Khanzadyan ML, Radzinskiy VE, Donnikov AE. The role of MMP and TIMP genetic polymorphisms in genital prolapse genesis. Medical Herald of the South of Russia. 2017;8(4):82–87. (In Russ.) DOI: 10.21886/2219-8075-2017-8-4-82-87

[48] Ханзадян М.Л., Радзинский В.Е., Донников А.Е. Роль генетических полиморфизмов ММР и TIMP в генезе пролапса гениталий // Медицинский вестник Юга России. 2017. Т. 8. № 4. С. 82–87. DOI: 10.21886/2219-8075-2017-8-4-82-87

[49] Rusina EI, Bezhenar VF, Ivashchenko TE, et al. The specific features of MMP1, MMP3, and PAI1 gene polymorphisms in patients with pelvic organ prolapse and stress urinary incontinence. Obstetrics and Gynegology. 2014.(9):63–68. (In Russ.)

[50] Русина Е.И., Беженарь В.Ф., Иващенко Т.Э., и др. Особенности полиморфизма генов MMP1, MMP3, PAI1 у больных с пролапсом тазовых органов и стрессовым недержанием мочи // Акушерство и гинекология. 2014. № 9. С. 63–68.

[51] Dubinskaya ЕD, Коlesnikova SN, Khamoshina МB, et al. NAT2 gene polymorphism as a predictor of failure for surgical treatment of pelvic organ prolapse: results of a prospective cohort clinical study. Annals of the Russian academy of medical sciences. 2017;72(6):466–472. (In Russ.) DOI: 10.15690/vramn901

[52] Дубинская Е.Д., Колесникова С.Н., Хамошина М.Б., и др. Полиморфизм гена NAT2 как предиктор рецидивов после хирургического лечения пролапса тазовых органов // Вестник Российской академии медицинских наук. 2017. Т. 72. № 6. С. 466–472. DOI: 10.15690/vramn901

[53] Cartwright R, Kirby AC, Tikkinen KA, et al. Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women. Am J Obstet Gynecol. 2015;212(2):199.e1–199.e24. DOI: 10.1016/j.ajog.2014.08.005

[54] Cartwright R., Kirby A.C., Tikkinen K.A., et al. Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women // Am. J. Obstet. Gynecol. 2015. Vol. 212. No. 2. P. 199.e1–199.e24. DOI: 10.1016/j.ajog.2014.08.005

[55] Khadzhieva MB, Kolobkov DS, Kamoeva SV, et al. Verification of the chromosome region 9q21 association with pelvic organ prolapse using regulomeDB annotations. Biomed Res Int. 2015;2015. (In Russ.) DOI: 10.1155/2015/837904

[56] Khadzhieva M.B., Kolobkov D.S., Kamoeva S.V., et al. Verification of the chromosome region 9q21 association with pelvic organ prolapse using regulomeDB annotations // Biomed Res. Int. 2015. Vol. 2015. DOI: 10.1155/2015/837904

[57] Fang G, Hong L, Liu C, et al. Oxidative status of cardinal ligament in pelvic organ prolapsed. Exp Ther Med. 2018;16(4):3293–3302. DOI: 10.3892/etm.2018.6633

[58] Fang G., Hong L., Liu C., et al. Oxidative status of cardinal ligament in pelvic organ prolapsed // Exp. Ther. Med. 2018. Vol. 16. No. 4. P. 3293–3302. DOI: 10.3892/etm.2018.6633

[59] Yilmaz N, Ozaksit G, Terzi YK, et al. HOXA11 and MMP2 gene expression in uterosacral ligaments of women with pelvic organ prolapsed. J Turk Ger Gynecol Assoc. 2014;15(2):104–108. DOI: 10.5152/jtgga.2014.0088

[60] Yilmaz N., Ozaksit G., Terzi Y.K., et al. HOXA11 and MMP2 gene expression in uterosacral ligaments of women with pelvic organ prolapsed // J. Turk. Ger. Gynecol. Assoc. 2014. Vol. 15. No. 2. P. 104–108. DOI: 10.5152/jtgga.2014.0088

[61] Liu C, Wang Y, Li BS, et al. Role of transforming growth factor β-1 in the pathogenesis of pelvic organ prolapse: a potential therapeutic target. Int J Mol Med. 2017;40(2):347–356. DOI: 10.3892/ijmm.2017.3042

[62] Liu C., Wang Y., Li B.S., et al. Role of transforming growth factor β-1 in the pathogenesis of pelvic organ prolapse: a potential therapeutic target // Int. J. Mol. Med. 2017. Vol. 40. No. 2. P. 347–356. DOI: 10.3892/ijmm.2017.3042

[63] Zhao B, Yan J, Wu H, et al. Interferon-γ and its pathway-associated gene expression in the vaginal tissue of premenopausal females with pelvic organ prolapsed. Exp Ther Med. 2014;8(4):1145–1149. DOI: 10.3892/etm.2014.1868

[64] Zhao B., Yan J., Wu H., et al. Interferon-γ and its pathway-associated gene expression in the vaginal tissue of premenopausal females with pelvic organ prolapsed // Exp. Ther. Med. 2014. Vol. 8. No. 4. P. 1145–1149. DOI: 10.3892/etm.2014.1868

[65] Borazjani A, Kow N, Harris S, et al. Transcriptional regulation of connective tissue metabolism genes in women with pelvic organ prolapse. Female Pelvic Med Reconstr Surg. 2017;23(1):44–52. DOI: 10.1097/SPV.0000000000000337

[66] Borazjani A., Kow N., Harris S., et al. Transcriptional regulation of connective tissue metabolism genes in women with pelvic organ prolapse // Female Pelvic Med. Reconstr. Surg. 2017. Vol. 23. No. 1. P. 44–52. DOI: 10.1097/SPV.0000000000000337

[67] Jakus IA, Jakus D, Aračić N, et al. Immunohistochemical expression of hypoxia-inducible factor-1α in stromal cells of vaginal tissue in post-menopausal women with pelvic organ prolapsed. Indian J Med Res. 2017;146:S63–S67. DOI: 10.4103/ijmr.IJMR_388_16

[68] Jakus I.A., Jakus D., Aračić N., et al. Immunohistochemical expression of hypoxia-inducible factor-1α in stromal cells of vaginal tissue in post-menopausal women with pelvic organ prolapsed // Indian J. Med. Res. 2017. Vol. 146. P. S63–S67. DOI: 10.4103/ijmr.IJMR_388_16

[69] Zhao X, Ma C, Li R, et al. Hypoxia induces apoptosis through HIF-1α signaling pathway in human uterosacral ligaments of pelvic organ prolapse. Biomed Res Int. 2017. Vol. 2017. DOI: 10.1155/2017/8316094

[70] Zhao X., Ma C., Li R., et al. Hypoxia induces apoptosis through HIF-1α signaling pathway in human uterosacral ligaments of pelvic organ prolapse // Biomed. Res. Int. 2017. Vol. 2017. DOI: 10.1155/2017/8316094

[71] Zhao X, Liu L, Li R, et al. Hypoxia-inducible factor 1-α (HIF-1α) induces apoptosis of human uterosacral ligament fibroblasts through the death receptor and mitochondrial pathways. Med Sci Monit. 2018;24:8722–8733. DOI: 10.12659/MSM.913384

[72] Zhao X., Liu L., Li R., et al. Hypoxia-inducible factor 1-α (HIF-1α) induces apoptosis of human uterosacral ligament fibroblasts through the death receptor and mitochondrial pathways // Med. Sci. Monit. 2018. Vol. 24. P. 8722–8733. DOI: 10.12659/MSM.913384

[73] Moloney GE, Gill WG, Barclay RC. Operations for hernia; technique of nylon darn. Lancet. 1948;2(6515):45–48. DOI: 10.1016/S0140-6736(48)90442-5

[74] Moloney G.E., Gill W.G., Barclay R.C. Operations for hernia; technique of nylon darn // Lancet. 1948. Vol. 2. No. 6515. P.45–48. DOI: 10.1016/S0140-6736(48)90442-5

[75] Calne RY. Repair of bilateral hernia. A technique using merselene mesh behind the rectus abdominus. Br J Surg. 1967;54(11):917–920. DOI: 10.1002/bjs.1800541103

[76] Calne R.Y. Repair of bilateral hernia. A technique using Mersilene mesh behind the rectus abdominus // Br. J. Surg. 1967. Vol. 54. No. 11. P. 917–920. DOI: 10.1002/bjs.1800541103

[77] Shkarupa DD. Khirurgicheskaya rekonstruktsiya tazovogo dna u zhenshchin pri nederzhanii mochi i prolapse tazovykh organov [abstract dissertation]. Saint Petersburg; 2014. (In Russ.) [cited 2022 Feb 14]. Available from: https://www.dissercat.com/content/khirurgicheskaya-rekonstruktsiya-tazovogo-dna-u-zhenshchin-pri-nederzhanii-mochi-i-prolapse-

[78] Шкарупа Д.Д. Хирургическая реконструкция тазового дна у женщин при недержании мочи и пролапсе тазовых органов: автореф. дис. … канд. мед. наук. Санкт-Петербург, 2014 [дата обращения 14.02.2022]. Доступ по ссылке: https://www.dissercat.com/content/khirurgicheskaya-rekonstruktsiya-tazovogo-dna-u-zhenshchin-pri-nederzhanii-mochi-i-prolapse-

[79] Sajid MS, Leaver C, Baig MK, et al. Systematic review and meta-analysis of the use of lightweight versus heavyweight mesh in open inguinal hernia repair. Br J Surg. 2012;99(1):29–37. DOI: 10.1002/bjs.7718

[80] Sajid M.S., Leaver C., Baig M.K., et al. Systematic review and meta-analysis of the use of lightweight versus heavyweight mesh in open inguinal hernia repair // Br. J. Surg. 2012. Vol. 99. No. 1. P. 29–37. DOI: 10.1002/bjs.7718

[81] Nygaard IE, McCreery R, Brubaker L, et al.; Pelvic Floor Disorders Network. Abdominal sacrocolpopexy: a comprehensive review. Obstet Gynecol. 2004; 104(4):805–823. DOI: 10.1097/01.AOG.0000139514.90897.07

[82] Nygaard I.E., McCreery R., Brubaker L., et al.; Pelvic floor disorders network. Abdominal sacrocolpopexy: a comprehensive review // Obstet. Gynecol. 2004. Vol. 104. No. 4. P. 805–823. DOI: 10.1097/01.AOG.0000139514.90897.07

[83] Illiano E, Giannitsas K, Zucchi A, et al. Sacrocolpopexy for posthysterectomy vaginal vault prolapse: long-term follow-up. Int Urogynecol J. 2016;27(10):1563–1569. DOI: 10.1007/s00192-016-2998-4

[84] Illiano E., Giannitsas K., Zucchi A., et al. Sacrocolpopexy for posthysterectomy vaginal vault prolapse: long-term follow-up // Int. Urogynecol. J. 2016. Vol. 27. No. 10. P. 1563–1569. DOI: 10.1007/s00192-016-2998-4

[85] Nosti PA, Umoh Andy U, Kane S, et al. Outcomes of abdominal and minimally invasive sacrocolpopexy: a retrospective cohort study. Female Pelvic Med Reconstr Surg. 2014;20(1):33–37. DOI: 10.1097/SPV.0000000000000036

[86] Nosti P.A., Umoh Andy U., Kane S., et al. Outcomes of abdominal and minimally invasive sacrocolpopexy: a retrospective cohort study // Female Pelvic Med. Reconstr. Surg. 2014. Vol. 20. No. 1. P. 33–37. DOI: 10.1097/SPV.0000000000000036

[87] Nezhat CH, Nezhat F, Nezhat C. Laparoscopic sacral colpopexy for vaginal vault prolapse. Obstet Gynecol. 1994;84(5):885–888.

[88] Nezhat C.H., Nezhat F., Nezhat C. Laparoscopic sacral colpopexy for vaginal vault prolapse // Obstet. Gynecol. 1994. Vol. 84. No. 5. P. 885–888.

[89] Higgs PJ, Chua HL, Smith AR. Long term review of laparoscopic sacrocolpopexy. BJOG. 2005;112(8):1134–1138. DOI: 10.1111/j.1471-0528.2005.00646.x

[90] Higgs P.J., Chua H.L., Smith A.R. Long term review of laparoscopic sacrocolpopexy // BJOG. 2005. Vol. 112. No. 8. P. 1134–1138. DOI: 10.1111/j.1471-0528.2005.00646.x

[91] Maher C, Feiner B, Baessler K, et al. Surgery for women with apical vaginal prolapse. Cochrane Database Syst Rev. 2016;10(10). DOI: 10.1002/14651858.CD012376

[92] Maher C., Feiner B., Baessler K., et al. Surgery for women with apical vaginal prolapse // Cochrane Database Syst. Rev. 2016. Vol. 10. No. 10. DOI: 10.1002/14651858.CD012376

[93] Elliott DS, Krambeck AE, Chow GK. Long-term results of robotic assisted laparoscopic sacrocolpopexy for the treatment of high grade vaginal vault prolapse. J Urol. 2006;176(2):655–659. DOI: 10.1016/j.juro.2006.03.040

[94] Elliott D.S., Krambeck A.E., Chow G.K. Long-term results of robotic assisted laparoscopic sacrocolpopexy for the treatment of high grade vaginal vault prolapse // J. Urol. 2006. Vol. 176. No. 2. P. 655–659. DOI: 10.1016/j.juro.2006.03.040

[95] Germain A, Thibault F, Galifet M, et al. Long-term outcomes after totally robotic sacrocolpopexy for treatment of pelvic organ prolapse. Surg Endosc. 2013;27(2):525–529. DOI: 10.1007/s00464-012-2472-4

[96] Germain A., Thibault F., Galifet M., et al. Long-term outcomes after totally robotic sacrocolpopexy for treatment of pelvic organ prolapse // Surg. Endosc. 2013. Vol. 27. No. 2. P. 525–529. DOI: 10.1007/s00464-012-2472-4

[97] Pollard ME, Eilber KS, Anger JT. Abdominal approaches to pelvic prolapse repairs. Curr Opin Urol. 2013;23(4):306–311. DOI: 10.1097/MOU.0b013e3283619e36

[98] Pollard M.E., Eilber K.S., Anger J.T. Abdominal approaches to pelvic prolapse repairs // Curr. Opin Urol. 2013. Vol. 23. No. 4. P. 306–311. DOI: 10.1097/MOU.0b013e3283619e36

[99] Jefferis H, Price N, Jackson S. Laparoscopic hysteropexy: 10 years’ experience. Int Urogynecol J. 2017;28(8):1241–1248. DOI: 10.1007/s00192-016-3257-4

[100] Jefferis H., Price N., Jackson S. Laparoscopic hysteropexy: 10 years’ experience // Int. Urogynecol. J. 2017. Vol. 28. No. 8. P. 1241–1248. DOI: 10.1007/s00192-016-3257-4

[101] Bedford ND, Seman EI, O’Shea RT, et al. Effect of uterine preservation on outcome of laparoscopic uterosacral suspension. J Minim Invasive Gynecol. 2013;20(2):172–177. DOI: 10.1016/j.jmig.2012.10.014

[102] Bedford N.D., Seman E.I., O’Shea R.T., et al. Effect of uterine preservation on outcome of laparoscopic uterosacral suspension // J. Minim. Invasive Gynecol. 2013. Vol. 20. No. 2. P. 172–177. DOI: 10.1016/j.jmig.2012.10.014

[103] Jacquetin B, Cosson M, Debodinance P, et al. Vaginal mesh for prolapse: a randomized controlled trial. Obstet Gynecol. 2010;116(6):1457–1458. DOI: 10.1097/AOG.0b013e3181ff9781

[104] Jacquetin B., Cosson M., Debodinance P., et al. Vaginal mesh for prolapse: a randomized controlled trial // Obstet. Gynecol. 2010. Vol. 116. No. 6. P. 1457–1458. DOI: 10.1097/AOG.0b013e3181ff9781

[105] Miller D, Lucente V, Babin E, et al. Prospective clinical assessment of the transvaginal mesh technique for treatment of pelvic organ prolapse-5-year results. Female Pelvic Med Reconstr Surg. 2011;17(3):139–143. DOI: 10.1097/SPV.0b013e3182175da6

[106] Miller D., Lucente V., Babin E., et al. Prospective clinical assessment of the transvaginal mesh technique for treatment of pelvic organ prolapse-5-year results // Female Pelvic Med. Reconstr. Surg. 2011. Vol. 17. No. 3. P. 139–143. DOI: 10.1097/SPV.0b013e3182175da6

[107] Bezhenar VF, Palastin PM, Tolibova GKh. Vaginal erosion at a long time after synthetic implants insertion during gynecological surgery. RMJ. Medical Review. 2018;(10):17–21. (In Russ.)

[108] Беженарь В.Ф., Паластин П.М., Толибова Г.Х. Эрозии влагалища в отдаленные сроки после постановки синтетических имплантатов при гинекологических операциях // РМЖ. Медицинское обозрение. 2018. № 10. С. 17–21.

[109] Palastin PM. Puti profilaktiki eroziy stenki vlagalishcha pri korrektsii genital’nogo prolapsa sinteticheskimi iplantatami [abstract dissertation]. Saint Petersburg; 2019. (In Russ.) [cited 2022 Feb 14]. Available from: https://www.dissercat.com/content/puti-profilaktiki-erozii-stenki-vlagalishcha-pri-korrektsii-genitalnogo-prolapsa-sintetiches

[110] Паластин П. М. Пути профилактики эрозий стенки влагалища при коррекции генитального пролапса синтетическими иплантатами: автореф. дис … канд. мед. наук. Санкт-Петербург, 2019 [дата обращения 14.02.2022]. Доступ по ссылке: https://www.dissercat.com/content/puti-profilaktiki-erozii-stenki-vlagalishcha-pri-korrektsii-genitalnogo-prolapsa-sintetiches

[111] Kasyan GR, Abramyan KN, Popov AA, et al. Risk factors associated with perioperative and mesh-related complications for patients undergoing pelvic organ prolapse surgery: analysis of 677 cases. European Urology. 2013;12(1):e115–e116. DOI: 10.1016/S1569-9056(13)60607-7

[112] Kasyan G.R., Abramyan K.N., Popov A.A., et al. Risk factors associated with perioperative and mesh-related complications for patients undergoing pelvic organ prolapse surgery: analysis of 677 cases // European Urology. 2013. Vol. 12. No. 1. P. e115–e116. DOI: 10.1016/S1569-9056(13)60607-7

[113] Haylen BT, Freeman RM, Swift SE, et al. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint terminology and classification of the complications related directly to the insertion of prostheses (meshes, implants, tapes) and grafts in female pelvic floor surgery. Neurourol Urodyn. 2011;30(1):2–12. DOI: 10.1002/nau.21036

[114] Haylen B.T., Freeman R.M., Swift S.E., et al. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint terminology and classification of the complications related directly to the insertion of prostheses (meshes, implants, tapes) and grafts in female pelvic floor surgery // Neurourol. Urodyn. 2011. Vol. 30. No. 1. P. 2–12. DOI: 10.1002/nau.21036

[115] Bezhenar VF, Bogatyreva EV, Tsypurdeyeva AA, et al. Complications from pelvic organ prolapse correction using a Prolift prolene system: ways of prevention and quality of life. Obstetrics and Gynecology. 2012;(4/2):116–121. (In Russ.)

[116] Беженарь В.Ф. Осложнения при коррекции тазового пролапса с использованием проленовой системы Prolift // Акушерство и гинекология. 2012. № 4/2. С. 116–121.

[117] Pushkar D, Malkhasyan V, Kasyan G, et al. Anatomical and functional results in patients treated for pelvic organ prolapse using Prolift transvaginal mesh: a prospective study of 105 cases. European Urology. 2011;10(2):245. (In Russ.) DOI: 10.1016/S1569-9056(11)60760-4

[118] Pushkar D., Malkhasyan V., Kasyan G., et al. Anatomical and functional results in patients treated for pelvic organ prolapse using Prolift transvaginal mesh: a prospective study of 105 cases // European Urology. 2011. Vol. 10. No. 2. P. 245. DOI: 10.1016/S1569-9056(11)60760-4

[119] US Food and Drug Administration, Center for Devices and Radiological Health. FDA Public Health Notification: serious complications associated with transvaginal placement of surgi cal mesh in repair of pelvic organ prolapse and stress urinary incontinence [cited 2022 Aug 15]. Available from: http://www.amiform.com/web/documents-risques-op-coelio-vagi/fda-notification-about-vaginal-mesh.pdf

[120] US Food and Drug Administration, Center for Devices and Radiological Health. FDA Public Health Notification: Serious complications associated with transvaginal placement of surgi cal mesh in repair of pelvic organ prolapse and stress urinary incontinence [дата обращения 15.08.2022]. Доступ по ссылке: http://www.amiform.com/web/documents-risques-op-coelio-vagi/fda-notification-about-vaginal-mesh.pdf

[121] Plekhanov AN, Bezhenar VF, Epifanova TA, et al. Comparative characteristics of hemostasis during vaginal hysterectomy. Kubanskii Nauchnyi Meditsinskii Vestnik. 2019;26(6):61–69. (In Russ.) DOI: 10.25207/1608-6228-2019-26-6-61-69

[122] Плеханов А.Н., Беженарь В.Ф., Епифанова Т.А., и др. Сравнительная характеристика методов гемостаза при влагалищной гистерэктомии // Кубанский научный медицинский вестник. 2019. Т. 26. № 6. С. 61–69. DOI: 10.25207/1608-6228-2019-26-6-61-69

[123] de Lancey JO. Anatomic aspects of vaginal eversion after hysterectomy. Am J Obstet Gynecol. 1992;166:1717–1724. DOI: 10.1016/0002-9378(92)91562-o

[124] de Lancey J.O. Anatomic aspects of vaginal eversion after hysterectomy // Am. J. Obstet. Gynecol. 1992. Vol. 166. P. 1717–1724. DOI: 10.1016/0002-9378(92)91562-o

[125] Benson AB, Venook AP, Al-Hawary MM, et al. NCCN Guidelines insights: rectal Cancer, version 6. 2020. J Natl Compr Canc Netw. 2020;18(7):806–815. DOI: 10.6004/jnccn.2020.0032

[126] Benson A.B., Venook A.P., Al-Hawary M.M., et al. NCCN guidelines insights: rectal cancer, version 6. 2020 // J. Natl. Compr. Canc. Netw. 2020. Vol. 18. No. 7. P. 806–815. DOI: 10.6004/jnccn.2020.0032

[127] Bullard KM, Trudel JL, Baxter NN, et al. Primary perineal wound closure after preoperative radiotherapy and abdominoperineal resection has a high incidence of wound failure. Dis Colon Rectum. 2005;48(3):438–443. DOI: 10.1007/s10350-004-0827-1

[128] Bullard K.M., Trudel J.L., Baxter N.N., et al. Primary perineal wound closure after preoperative radiotherapy and abdominoperineal resection has a high incidence of wound failure // Dis. Colon. Rectum. 2005. Vol. 48. No. 3. P. 438–443. DOI: 10.1007/s10350-004-0827-1

[129] Ryan S, Kavanagh DO, Neary PC. Laparoscopic repair of postoperative perineal hernia. Case Rep Med. 2010. Vol. 2010. DOI: 10.1155/2010/126483

[130] Ryan S., Kavanagh D.O., Neary P.C. Laparoscopic repair of postoperative perineal hernia // Case. Rep. Med. 2010. Vol. 2010. DOI: 10.1155/2010/126483

[131] Stelzner S, Sims A, Witzigmann H. Comment on Asplund et al.: outcome of extralevator abdominoperineal excision compared with standard surgery: results from a single centre. Colorectal Dis. 2013;15(5):627–628. DOI: 10.1111/codi.12116

[132] Stelzner S., Sims A., Witzigmann H. Comment on Asplund et al.: outcome of extralevator abdominoperineal excision compared with standard surgery: results from a single centre // Colorectal. Dis. 2013. Vol. 15. No. 5. P. 627–628. DOI: 10.1111/codi.12116

[133] Xu HR, Xu ZF, Li ZJ. Research progression of extralevator abdominoperineal excision. Zhonghua Wei Chang Wai KeZa Zhi. 2013;16(7):698–700.

[134] Xu H.R., Xu Z.F., Li Z.J. Research progression of extralevator abdominoperineal excision // Zhonghua Wei Chang Wai Ke Za Zhi. 2013. Vol. 16. No. 7. P. 698–700.

[135] Chokshi RJ, Kuhrt MP, Arrese D, et al. Reconstruction of total pelvic exenteration defects with rectus abdominus myocutaneous flaps versus primary closure. Am J Surg. 2013;205(1):64–70. DOI: 10.1016/j.amjsurg.2012.04.010

[136] Chokshi R.J., Kuhrt M.P., Arrese D., et al. Reconstruction of total pelvic exenteration defects with rectus abdominus myocutaneous flaps versus primary closure // Am. J. Surg. 2013. Vol. 205. No. 1. P. 64–70. DOI: 10.1016/j.amjsurg.2012.04.010

[137] Shinkarev SA, Latyshev YuP, Klycheva ON. Varianty plastiki tazovogo dna: dostoinstva i nedostatki. In: Stoletnyaya shkola kadrov, nauchnogo poiska, metodicheskoy pomoshchi prakticheskomu zdravookhraneniyu: sbornik nauchnykh statey. Ed. by A.D. Kaprin. Voronezh: Nauchnaya kniga; 2018. P. 200–202. (In Russ.)

[138] Шинкарев С.А., Латышев Ю.П., Клычева О.Н. Варианты пластики тазового дна: достоинства и недостатки // Столетняя школа кадров, научного поиска, методической помощи практическому здравоохранению: сборник научных статей / под ред. А.Д. Каприна. Воронеж: Научная книга, 2018. С. 200–202.

[139] Bezhenar’ VF, Plekhanov AN., et al. Sovremenn·yye metody korrektsii redkikh i slozhnykh form prolapsa tazovykh organov. In: Nedostatochnost’ tazovogo dna. Terapiya na osnove dostizheniy nauki i klinicheskoy praktiki. Ed. by V.F. Bezhenar’, G.B. Dikke, Ye.Yu. Glukhov. Moscow: ABV-press; 2021. P. 385–396. (In Russ.)

[140] Беженарь В.Ф., Плеханов А.Н. и др. Современные методы коррекции редких и сложных форм пролапса тазовых органов // Недостаточность тазового дна. Терапия на основе достижений науки и клинической практики / под ред. В.Ф. Беженаря, Г.Б. Дикке, Е.Ю. Глухова. Москва: АБВ-пресс, 2021. С. 385–396.

[141] Bezhenar’ V.F., Plekhanov A.N., et al. Sovremenn·yye metody khirurgicheskoy korrektsii pri prolapse tazovykh organov organov. In: Nedostatochnost’ tazovogo dna. Terapiya na osnove dostizheniy nauki i klinicheskoy praktiki. Ed. by V.F. Bezhenar’, G.B. Dikke, Ye.Yu. Glukhov. Moscow: ABV-press; 2021. P. 337–383. (In Russ.)

[142] Беженарь В.Ф., Плеханов А.Н. и др. Современные методы хирургической коррекции при пролапсе тазовых органов // Недостаточность тазового дна. Терапия на основе достижений науки и клинической практики / под ред. В.Ф. Беженаря, Г.Б. Дикке, Е.Ю. Глухова. Москва: АБВ-пресс, 2021. С. 337–383.

[143] Plekhanov AN, Bezhenar VF, Epifanova TA, et al. Randomized comparative study of the effectiveness and safety of various bipolar devices during electrosurgical vaginal hysterectomy. Journal of Obstetrics and Women’s Diseases. 2021;70(2):45–54. (In Russ.) DOI: 10.17816/JOWD71084

[144] Плеханов А.Н., Беженарь В.Ф., Епифанова Т.А., и др. Рандомизированное сравнительное исследование эффективности и безопасности различных биполярных устройств при выполнении электрохирургической влагалищной гистерэктомии // Журнал акушерства и женских болезней. 2021. Т. 70. № 2. C. 45–54. DOI: 10.17816/JOWD71084

[145] Plekhanov AN, Bezhenar VF, Karachun AM, et al. Experience in surgical correction of genital prolapse caused by abdominoperineal operations for colon cancer in anamnesis. Journal of Obstetrics and Women’s Diseases. 2020;69(5):87–97. (In Russ.) DOI: 10.17816/JOWD69587-97

[146] Плеханов А.Н., Беженарь В.Ф., Карачун А.М., и др. Опыт хирургической коррекции генитального пролапса, обусловленного брюшно-промежностными операциями по поводу рака толстой кишки в анамнезе // Журнал акушерства и женских болезней. 2020. Т. 69. № 5. C.87–97. DOI: 10.17816/JOWD69587-97

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