The review represents recent data devoted to pathogenesis of the brain ischemia and pharmacological ways to correct metabolic shifts in the cerebral blood flow disorders.
The calculation of physicochemical parameters and biological activities has been conducted for 11 2,6-di-tert-butylreplaced thio(amino)alkylphenols by means of computer programs ALOGPS, GUSAR and PASS. It is shown that phenols are characterized by their lower water solubility, higher lipophilicity, they are weak and middle toxic substances (4th and 5th danger class), they possess neither mutagenic nor teratogenic effect. The thio(amino)alkylphenols biological activity estimation indicated that they can be considered as potential means for treatment of free radical pathologies. The gained results of the prognosis open wide medical and biological potentials of thio(amino)alkylphenols and may serve as a theoretical base for planning further experimental re-searches in biological systems.
We have investigated age-related changes in the activity of antioxidant enzyme system and intensity of lipid peroxidation in erythrocytes of young and old female rhesus monkeys with depression-like and standard behavior. Revealed significant disturbances in the activities of GR and GSH-Px in monkeys with depression-like behavior are accompanied more pronounced age-related decrease in reliability of antioxidant enzyme defense and development of oxidative stress.