The influence of the extract of Panax ginseng on the behavior of chronically alcoholized Danio rerio during ethanol withdrawal

Abstract

BACKGROUND: The search for new ways to correct the pathophysiological mechanisms underlying the alcohol withdrawal syndrome is an urgent and promising direction in the pharmacotherapy of alcoholism. The extract of Panax ginseng is of interest in relation to the correction of pathological behaviors caused by long-term alcohol consumption. With the help of behavioral tests, you can evaluate the features of various forms of behavior.

AIM: To study the effect of Panax ginseng extract solution on the behavior of Danio rerio fish during the period of alcohol withdrawal after prolonged alcoholization.

MATERIALS AND METHODS: Prolonged alcoholization was modeled by placing the fish in an aquarium with 0.3 ethanol solution for 14 days. After the abolition of ethanol, intraperitoneal injections of Panax ginseng root extract solution (0.3 mg / 1 g) were performed for 7 days. The behavior of fish was studied in the test “Motor activity in a new place and after habituation”.

RESULTS: The article presents the results of the effect of Panax ginseng extract solution on the behavior of Danio rerio fish during the period of alcohol withdrawal after prolonged alcoholization. The time spent in sections in the Panax ginseng (0.3 mg / 1 g) injection group was restored to control levels compared to the alcohol withdrawal group of fish injected with saline.

CONCLUSIONS: The study showed that the behavior of Danio rerio fish in the test “Motor activity in a new place and after habituation” was subject to changes, while the Panax ginseng extract recover the behavioral changes of the fish up to control indexes.

Keywords

ethanol withdrawal / brain / Danio rerio / Panax ginseng / behavior

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RIGHTS & PERMISSIONS

Airapetov M.I., Eresko S.O., Galustyan A.N., Lebedev A.A., Shabanov P.D.