Despair-like behavior in fish based on the zebrafish (Danio rerio)

Abstract

The zebrafish tail immobilization test is a relatively new method for analyzing zebrafish behavior, based on the paradigm of learned helplessness, when the animal is exposed to an uncontrollable stressor, and soon abandons all attempts to avoid the aversive stimulus, adopting a posture of immobility. As an aversive stimulus acts restraining fish tail in a viscose sponge, without restricting the mobility of the lateral fins and the front of the body. The zebrafish tail immobilization test is suitable for detecting depressive-like ‘despair’ behavior in zebrafish, paralleling clinical apathy and lethargy in depression.

Keywords

zebrafish / despair / antidepressants / tail immobilization / learned helplessness

References

[1] Bernal-Morales B, Contreras CM, Cueto-Escobedo J. Acute restraint stress produces behavioral despair in weanling rats in the forced swim test. Behav Processes. 2009;82(2):219–222. DOI: 10.1016/j.beproc.2009.06.006

[2] Bernal-Morales B., Contreras C.M., Cueto-Escobedo J. Acute restraint stress produces behavioral despair in weanling rats in the forced swim test // Behav Processes. 2009. Vol. 82, No. 2. P. 219–222. DOI: 10.1016/j.beproc.2009.06.006

[3] Swiergiel AH, Leskov IL, Dunn AJ. Effects of chronic and acute stressors and CRF on depression-like behavior in mice. Behav Brain Res. 2008;186(1):32–40. DOI: 10.1016/j.bbr.2007.07.018

[4] Swiergiel A.H., Leskov I.L., Dunn A.J. Effects of chronic and acute stressors and CRF on depression-like behavior in mice // Behav Brain Res. 2008. Vol. 186, No. 1. P. 32–40. DOI: 10.1016/j.bbr.2007.07.018

[5] Ostadhadi S, Haj-Mirzaian A, Nikoui V, et al. Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice. Clin Exp Pharmacol Physiol. 2016;43(2):203–212. DOI: 10.1111/1440-1681.12518

[6] Ostadhadi S., Haj-Mirzaian A., Nikoui V., et al. Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice // Clin Exp Pharmacol Physiol. 2016. Vol. 43, No. 2. P. 203–212. DOI: 10.1111/1440-1681.12518

[7] Haj-Mirzaian A, Ostadhadi S, Kordjazy N, et al. Opioid/NMDA receptors blockade reverses the depressant-like behavior of foot shock stress in the mouse forced swimming test. Eur J Pharmacol. 2014;735:26–31. DOI: 10.1016/j.ejphar.2014.03.053

[8] Haj-Mirzaian A., Ostadhadi S., Kordjazy N., et al. Opioid/NMDA receptors blockade reverses the depressant-like behavior of foot shock stress in the mouse forced swimming test // Eur J Pharmacol. 2014. Vol. 735. P. 26–31. DOI: 10.1016/j.ejphar.2014.03.053

[9] Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci. 2002;23(5):238–245. DOI: 10.1016/s0165-6147(02)02017-5

[10] Cryan J.F., Markou A., Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs // Trends Pharmacol Sci. 2002. Vol. 23, No. 5. P. 238–245. DOI: 10.1016/s0165-6147(02)02017-5

[11] Ma L, Demin KA, Kolesnikova TO, et al. Animal inflammation-based models of depression and their application to drug discovery. Expert Opin Drug Discov. 2017;12(10):995–1009. DOI: 10.1080/17460441.2017.1362385

[12] Ma L., Demin K.A., Kolesnikova T.O., et al. Animal inflammation-based models of depression and their application to drug discovery // Expert Opin Drug Discov. 2017. Vol. 12, No. 10. P. 995–1009. DOI: 10.1080/17460441.2017.1362385

[13] Demin KA, Lakstygal AM, Chernysh MV, et al. The zebrafish tail immobilization (ZTI) test as a new tool to assess stress-related behavior and a potential screen for drugs affecting despair-like states. J Neurosci Methods. 2020;337:108637. DOI: 10.1016/j.jneumeth.2020.108637

[14] Demin K.A., Lakstygal A.M., Chernysh M.V., et al. The zebrafish tail immobilization (ZTI) test as a new tool to assess stress-related behavior and a potential screen for drugs affecting despair-like states // J Neurosci Methods. 2020. Vol. 337. ID 108637. DOI: 10.1016/j.jneumeth.2020.108637

RIGHTS & PERMISSIONS

Galstyan D.S., Kolesnikova T.O., Kositsyn Y.M., Zabegalov K.N., Gubaidullina M.A., Maslov G.O., Demin K.A., Kalueff A.V.