Evaluation of the bioavailability of 1H-imidazole-4,5-dicarboxylic acid derivatives using the calculated and experimental lipophilicity index of the molecule logP

Abstract

BACKGROUND: It is important to know the ability of a substance to penetrate the cell membrane to assess the bioavailability of drugs. The distribution of matter between the organic phase and water can be used as a model of the distribution between the membrane and extracellular fluid, and can be expressed by a partion coefficient, called logP.

AIM: The aim of this work was to determine the logP of 1H-imidazole-4,5-dicarboxylic acid (IDC) derivatives in various media and compare the values with theoretical ones.

RESULTS: As a result of the work, the distribution coefficients of the IDC derivatives were determined from the optical density data for a fixed wavelength of 250 nm (without a buffer). The distribution coefficients of the IDC derivatives over the maxima of the UV spectra (in the buffer) were determined. A comparison of theoretical and experimental values of the distribution coefficients of some IDC derivatives is carried out.

CONCLUSION: Thus, it has been shown that for a more accurate assessment of the bioavailability of drugs, it is not enough to rely only on the calculated logP index, it is necessary to conduct an experimental test, or introduce some correction factors to recalculate the theoretical logP index, in each specific class of compounds.

Keywords

1H-imidazole-4,5-dicarboxylic acid / logP / bioavailability of drugs

References

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RIGHTS & PERMISSIONS

Iljin V.V., Litasova E.V., Kvasov M.S., Brusina M.A., Piotrovskiy L.B.