Assessment of retinal photosensitivity as an objective indicator of expression psychodense effect

Abstract

BACKGROUND: The retina of the eye, with its wide range of neurotransmitter systems, can be the point of application in the action of the psychotropic drugs, given their synaptotropic properties.

MATERIALS AND METHODS: In this regard, a complex of studies was carried out with the participation of volunteers to assess the effect of psychotropic substances with a depressing (melatonin, grandaxin, motherwort tincture) type of action on the functional state of the retina, registered by the campimetric method. In the course of the research, the photosensitivity of the retina and its ability to distinguish colors were evaluated. Moreover, the capabilities of the technique made it possible to assess retinal activity in the field of view from 0 to 21°. Such an approach can not only demonstrate the interest of retinal cellular elements in the action of substances, but also raise the question of the participation of the visual system in the psychopharmacological effect more broadly.

RESULTS: The work of the visual apparatus was studied both in healthy volunteers of different ages and in persons with emotional disorders, which were identified using special questionnaire tests. It was found that violations of the emotional status are often accompanied by a limitation of the photosensitivity of the retina of varying severity. These facts can be interpreted in different ways. On the one hand, violations of visual functions can lead to psychoemotional disorders and be a pathogenetic link in their development, and on the other hand, primary disorders of retinal light and color sensitivity can provoke the development of psychopathology. However, regardless of the pharmacological characteristics of the studied drugs with psychodeprimating activity, the connection between their anti-anxiety effect and changes in visual function seems to be obvious, which allows us to raise the question of the advisability of taking into account the photosensitivity of the retina for a comprehensive assessment of both the mental state of emotionally labile subjects and the pharmacodynamics of psychodemitting drugs.

CONCLUSIONS: Thus, it is legitimate to conclude that taking into account the light and color sensitivity of the retina can be one of the quantitative criteria for the severity and effectiveness of psychopharmacotherapy.

Keywords

tofisopam / melatonin / campimetry / retina

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RIGHTS & PERMISSIONS

Ovanesov K.B., Shabanov P.D.