Comparative evaluation of the antistress effect of phenazepam, melatonin and their combination

Eduard B. Arushanian; Olga Vladimirovna; Eduard Vladimirovich Beyer

doi:10.17816/RCF191107-110

Reviews on Clinical Pharmacology and Drug Therapy ›› 2021, Vol. 19 ›› Issue (1) : 107 -110. DOI: 10.17816/RCF191107-110

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Comparative evaluation of the antistress effect of phenazepam, melatonin and their combination

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Abstract

Phenazepam and melatonin reduce anxiety in stressed rats, and their anxiolytic effect is enhanced in combination. Melatonin also limits stress-induced increases in sympathetic activity and eliminates the dysregulatory effect of phenazepam on the main indicators of heart rate variability.

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phenazepam / melatonin / anti-stress effect

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Eduard B. Arushanian, Olga Vladimirovna, Eduard Vladimirovich Beyer. Comparative evaluation of the antistress effect of phenazepam, melatonin and their combination. Reviews on Clinical Pharmacology and Drug Therapy, 2021, 19(1): 107-110 DOI:10.17816/RCF191107-110

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References

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[1]	Arushanian EB. Anksiolitiki. Stavropol: StGMA; 2001.240 p. (In Russ.)

[2]	Арушанян Э.Б. Анксиолитические средства. Ставрополь: СтГМА, 2001. 240 с.

[3]	Arushanian EB, Kaminskaya OV, Beyer EV. Hronobiologicheskie dokazatelstva anksioliticheskogo deistviya melatonina. Experimental and Clinical Pharmacology. 2018;81(Suppl 1):17. (In Russ.)

[4]	Арушанян Э.Б., Каминская О.В., Бейер Э.В. Хронобиологические доказательства анксиолитического действия мелатонина // Экспериментальная и клиническая фармакология. 2018. Т. 81. Прил. 1.. С. 17.

[5]	Arushanian EB, Beyer EV. Melatonin (biologiya, farmacologiya, klinika). Stavropol: ARGUS; 2015. 396 p. (In Russ.)

[6]	Арушанян Э.Б., Бейер Э.В. Мелатонин (биология, фармакология, клиника). Ставрополь: АГРУС, 2015. 396 с.

[7]	Otmani S, Demazieres A, Staner C, et al. Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers. Hum Psychopharmacol. 2008;23(8):693–705. DOI: 10.1002/hup.980

[8]	Otmani S., Demazières A., Staner C, et al. Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers // Hum Psychopharmacol. 2008. Vol. 23, No. 8. P. 693–705. DOI: 10.1002/hup.980

[9]	Kaminskaya OV, Beyer EV, Arushanian EB. Assessment of the action of melatonin and fluoxetin on the model of resinpina depression. Medical News of North Caucasus. 2017;12(2):180–183. (In Russ.). DOI: 10.14300/mnnc.2017.12050

[10]	Каминская О.В., Бейер Э.В., Арушанян Э.Б. Сравнительная оценка действия мелатонина и флуоксетина на модели резерпиновой депрессии // Медицинский вестник Северного Кавказа. 2017. Т. 12. № 2. С. 180–183. DOI: 10.14300/mnnc.2017.12050