Lipid-lowering and anti-atherosclerotic activity of the natural original enzyme preparation in the experiment
Irina V. Okunevich , Natalia N. Klyueva , Nina S. Parfenova , Elena V. Belova
Reviews on Clinical Pharmacology and Drug Therapy ›› 2019, Vol. 17 ›› Issue (3) : 79 -84.
Lipid-lowering and anti-atherosclerotic activity of the natural original enzyme preparation in the experiment
The experimental large-scale investigation in vitro and in vivo is devoted to the results of a long-term study of the biological, lipid-lowering and anti-atherosclerotic activity of the original natural microbial enzyme preparation of cholesterol oxidase (CHO). In chronic experiments (rats, rabbits, dogs), low toxicity, good tolerability, and anti-atherosclerotic activity of the CHO preparation were established. To assess the effect of CHO in conditions of moderate nutritional dyslipoproteinemia, experiments were carried out in 3 species of animals (rats, guinea pigs, rabbits). It was shown the pronounced lipid-lowering effect of CHO in modeling dyslipoproteinemia.
cholesterol / atherosclerosis / dyslipoproteinemia / cholesterol oxidase
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Okunevich I.V., Klyueva N.N., Parfenova N.S., Belova E.V.
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