II-Valent metals complex compounds and prospects of the acute hypoxia protection
Andrey V. Evseev , Albert E. Belenky , Dmitrij V. Surmenev , Marina A. Evseeva , Denis V. Sosin
Reviews on Clinical Pharmacology and Drug Therapy ›› 2019, Vol. 17 ›› Issue (1) : 53 -56.
II-Valent metals complex compounds and prospects of the acute hypoxia protection
Aim. To find antihypoxic properties in complex compounds of some divalent metals on the model of acute hypoxia with hypercapnia.
Methods. In the experiments on mice in acute hypoxia with hypercapnia (AH+Hc), the protective effect of 6 new complex compounds was studied in comparison with the effectiveness of reference antihypoxants. Substances were injected intraperitoneally 60 min before acute hypoxia with hypercapnia in doses of 25 and 50 mg/kg. Antihypoxic effect was compared with their ability to change the rectal temperature.
Results. The most active substance πQ-2116 with Nickel as a complexing metal was established. Mice resistance to acute hypoxia with hypercapnia at a dose of 25 mg/kg was increased to 89.5%, at a dose of 50 mg/kg – to 165.8%. The effect was accompanied by serious hypothermia, reaching 28.5 °C. Antihypoxic activity of the substance πQ-2116 is comparable with reference substance πQ-1983 and greater than the effect of aminothiol antihypoxants – Amtizole and Sunazole.
mice / acute hypoxia / metal-complex compounds / antihypoxants
| [1] |
Методические рекомендации по экспериментальному изучению препаратов, предлагаемых для клинического изучения в качестве антигипоксических средств / Под ред. Л.Д. Лукьяновой. – М., 1990. – 19 с. [Metodicheskie rekomendatsii po eksperimental’nomu izucheniyu preparatov, predlagaemykh dlya klinicheskogo izucheniya v kachestve antigipoksicheskikh sredstv. Ed. by L.D. Lukyanova. Moscow; 1990. 19 p. (In Russ.)] |
| [2] |
Парфёнов Э.А., Смирнов Л.Д., Дюмаев К.М. Стратегические направления медицинского применения антиоксидантов. В кн.: Человек и лекарство: Тезисы докладов IX Российского национального конгресса. – М., 2002. – С. 765. [Parfenov EA, Smirnov LD, Dyumaev KM. Strategicheskie napravleniya meditsin-skogo primeneniya antioksidantov. In: Chelovek i lekarstvo: Tezisy dokladov IX Rossiyskogo natsional’nogo kongressa. Moscow; 2002. p. 765. (In Russ.)] |
| [3] |
Евсеев А.В., Сурменёв Д.В., Парфёнов Э.А., и др. Тестирование на модели острой гипоксии с гиперкапнией новых металлокомплексных селенсодержащих соединений // Обзоры по клинической фармакологии и лекарственной терапии. – 2017. – Т. 15. – № 4. – С. 46–52. [Evseev AV, Surmenev DV, Parfenov EA, et al. Testing of new selenium containing metal complex compounds by acute hypoxia-hypercapnia method. Reviews of clinical pharmacology and drug therapy. 2017;15(4):46-52. (In Russ.)]. https://doi.org/10.17816/RCF15446-52 |
| [4] |
Шабанов П.Д., Зарубина И.В., Новиков В.Е., Цыган В.Н. Метаболические корректоры гипоксии / Под ред. А.Б. Белевитина. – СПб: Информ-Новигатор, 2010. – 912 с. [Shabanov PD, Zarubina IV, Novikov VE, Tsygan VN. Metabolicheskie korrektory gipoksii. Ed. by A.B. Belevitin. Saint Petersburg: Inform-Navigator; 2010. 912 p. (In Russ.)] |
| [5] |
Goldberg M, Dunning S, Bunn H. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science. 1988;242(4884):1412–1415. https://doi.org/10.1126/science.2849206. |
| [6] |
Salnikow K, Blagosklonny MV, Ryan H, et al. Carcinogenic nickel induces genes involved with hypoxic stress. Cancer Res. 2000;60(1):38-41. |
Evseev A.V., Belenky A.E., Surmenev D.V., Evseeva M.A., Sosin D.V.
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