Maintenance pharmacotherapy of atopic dermatitis

Inna V. Petrova; Najmudin N. Omarov; Misha S. Sargsyan; Saiyora A. Khamroeva; Zarema S. Osmanova; Sergei N. Proshin

doi:10.17816/RCF16160-63

Reviews on Clinical Pharmacology and Drug Therapy ›› 2018, Vol. 16 ›› Issue (1) : 60 -63. DOI: 10.17816/RCF16160-63

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Maintenance pharmacotherapy of atopic dermatitis

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Abstract

Abstract. Atopic dermatitis (AD) — multifactorial inflammatory disease of skin characterized by pruritus, chronic recurrent process and age-related features of localization and morphology of lesions. This is one of most spread disease of skin up to 40%, meeting in all countries, in both sexes, in different age groups.

The aim. Prevention of severe forms of AD and complications.

Methods. To estimate the degree of atopic dermatitis was used international scale SCORAD (Scoring of Atopic Dermatitis). Results and discussion. At present time the pathogenesis of atopic dermatitis is discussed in terms of heredity resulting in disturbance of skin barrier, deficiency of immune system. The later means the stimulation of Th2-cells resulting in hyperproduction of IgE, hypersensitivity to allergens and nonspecific stimulants, colonization by pathogenic microorganism such as Staphylococcus aureus, Malassezia furfur and so on. The imbalance of autonomous nerve system with increased production of inflammatory mediators is strongly considered in the pathogenesis of atopic dermatitis too.

Conclusion. Considering the multifactoriality of atopic dermatitis the maintenance pharmacotherapy is of particular importance.

Keywords

atopic dermatitis / maintenance pharmacotherapy

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Inna V. Petrova, Najmudin N. Omarov, Misha S. Sargsyan, Saiyora A. Khamroeva, Zarema S. Osmanova, Sergei N. Proshin. Maintenance pharmacotherapy of atopic dermatitis. Reviews on Clinical Pharmacology and Drug Therapy, 2018, 16(1): 60-63 DOI:10.17816/RCF16160-63

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