Safety study of fentanyl and dexmedetomidine combination in an experimental model of respiratory failure
Nikolay G. Vengerovich , Mikhail A. Judin , Yury O. Kon’shakov , Konstantin A. Sherbasov , Stanislav V. Gadzikovskiy , Olga O. Vladimirova , Irina I. Alekseeva
Reviews on Clinical Pharmacology and Drug Therapy ›› 2016, Vol. 14 ›› Issue (3) : 53 -57.
Safety study of fentanyl and dexmedetomidine combination in an experimental model of respiratory failure
In an experimental model of respiratory failure induced by a single intraperitoneal injection of 1 LD50 of paraquat (24 mg/kg) the changes of physical activity tolerance, respiratory function parameters were studied and histomorphologic validation of experimental results was confirmed. In a model of respiratory failure the assessment of analgesic activity and toxicity of fentanyl, dexmedetomidine and their combination was made and compared with intact animals. The integral tolerance rates (therapeutic action width) were also estimated. It was shown that on the background of pulmonary pathology for each of the drugs 13-28% decrease of average lethal doses was observed. At the same time when administered in combination an average effective dose of the drugs wasn’t changed in contrast with single-drug analgesia.
fentanyl / dexmedetomidine / respiratory failure / combination therapy
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Vengerovich N.G., Judin M.A., Kon’shakov Y.O., Sherbasov K.A., Gadzikovskiy S.V., Vladimirova O.O., Alekseeva I.I.
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