Cortisol and BDNF levels in depression within schizophrenia structure: approach to treating

Abstract

To evaluate the effect of depression on the level of cortisol and BDNF in patients with schizophrenia 25 inpatients, who met the diagnostic criteria for ICD-10 schizophrenia (F20), were examined. The examination included clinical, psychopathological, laboratory and psychometric methods. Patients were examined twice: at admission and after 6 weeks of treatment. It was found that the level of BDNF in schizophrenic patients with depressive symptoms was significantly lower than that of non-depressed patients, and the level of cortisol in patients with depression was significantly higher.

Keywords

schizophrenia / depression / brain-derived neurotrophic factor / cortiso

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Nikiforova Y.S., Mazo G.E.