Effect of mother alcoholization on the activity of ghrelin system in prenatal and early postnatal periods of rat offspring

Marat Igorevich Airapetov; Platon Platonovich Khokhlov; Eugeny Rudolfovich Bychkov; Edgar Arturovich Sekste; Natalia Dmitrievna Yakushina; Andrei Andreevich Lebedev; Nikanor Vasilievich Lavrov; Petr Dmitriyevich Shabanov

doi:10.17816/RCF13210-13

Reviews on Clinical Pharmacology and Drug Therapy ›› 2015, Vol. 13 ›› Issue (2) : 10 -13. DOI: 10.17816/RCF13210-13

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Effect of mother alcoholization on the activity of ghrelin system in prenatal and early postnatal periods of rat offspring

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Institute of Experimental Medicine

S. M. Kirov Military Medical Academy

Junior Researcher, S. V. Anichkov Dept. of Neuropharmacology

PhD (Biochemistry), Senior Researcher, S. V. Anichkov Dept. of Neuropharmacology

PhD (Biochemistry), Researcher, S. V. Anichkov Dept. of Neuropharmacology

Post-Graduate Student, S. V. Anichkov Dept. of Neuropharmacology

Dr. Biol. Sci. (Pharmacology), Professor, Leading Researcher

PhD (Pharmacology), Assistant Professor, Dept. of Pharmacology

Doct. of Med. Sci. (Pharmacology), Professor and Head, S. V. Anichkov Dept. of Neuropharmacology

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Abstract

The purpose of the paper was to study both the desacylghrelin (unacylated ghrelin) level in the blood serum and expression of mRNA ghrelin receptor in the brain structures in ontogeny after chronic alcoholization in rats. The results proved that the prenatal effect of ethanol negatively affected the maturation of dopaminergic and ghrelin systems of the brain as well as involvement of ghrelin system in mechanisms of alcohol dependence formation. The decrease of COMT mRNA expression simultaneoully with the increase of expression of D2 long and short isoforms of dopaminergic receptors and misbalance of ghrelin system were observed. Alcoholization of mothers reduced desacylghrelin level in the blood serum in early postnatal period in offsprings although mRNA expression of ghrelin receptor in the brain was elevated. Chronic alcoholization of adult rats also affected the ghrelin system. In the alcoholiztion process, the reduced contents of desacylghrelin in the blood serum with compensatory increase of ghrelin receptor expression in the brain were registered. After withdrawal of ethanol, the recovery of desacylghrelin level (tendency to normalization) was observed.

Keywords

desacylghrelin / expression of mRNA / ghrelin receptor / dopamine receptor / brain structures, ontogeny, alcoholization

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Marat Igorevich Airapetov, Platon Platonovich Khokhlov, Eugeny Rudolfovich Bychkov, Edgar Arturovich Sekste, Natalia Dmitrievna Yakushina, Andrei Andreevich Lebedev, Nikanor Vasilievich Lavrov, Petr Dmitriyevich Shabanov. Effect of mother alcoholization on the activity of ghrelin system in prenatal and early postnatal periods of rat offspring. Reviews on Clinical Pharmacology and Drug Therapy, 2015, 13(2): 10-13 DOI:10.17816/RCF13210-13

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