Pharmacokinetic peculiarities of intravenous and oral ciprofloxacin administration in preoperative prophylaxis in patients with benign prostatic hyperplasia

Abstract

The study of population pharmacokinetics of ciprofloxacin at various ways of administration helps to found that the once usage of 500 mg ciprofloxacin orally 90-120 min before the surgery as preoperative antibiotic prophylaxis with transurethral resection of the prostate gland creates a significantly higher concentration of the drug in blood, urine and prostate parenchyma compared to intravenously administration of 400 mg ciprofloxacin 30-60 min before operation. Thus, the data obtained explain the higher efficacy of oral administration of ciprofloxacin as preoperative antibiotic prophylaxis in patients undergoing transurethral resection of the prostate.

Keywords

ciprofloxacin / benign prostatic hyperplasia / preoperative antibiotic prophylaxis

References

[1] Беленький Л. М. Элементы количественной оценки фармакологического эффекта. - Рига, 1963. - 116 с.

[2] Коган М. И, Рафальский В. В., Страчунский Л. С. и др. Эффективность и безопасность перорального и внутривенного применения ципрофлоксацина для антибиотикопрофилактики при трансуретральной резекции предстательной железы // Consilium medicum. - 2006. - № 4. - С. 12-16.

[3] Мартов А. Г., Лопаткин Н. А., Гущин Б. Л., Чепуров А. К. Руководство по трансуретральной эндоскопической электрохирургии доброкачественной гиперплазии простаты. - М.: Трондо-Х, 2006. - 144 с.

[4] Саркулова М. Н. Профилактика и лечение госпитальной инфекции мочевых путей при малоинвазивных урологических вмешательствах: Автореф. дис… д-ра мед. наук. - М., 2009. - 44 с.

[5] Vos Th., Flaxman A. D., Naghvai M. et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 // Lancet. - 2012. - Vol. 380, Iss. 9859. - P. 2163-2196.

[6] Verhamme K., Dieleman J. P., Bleumink G. S. et al. Incidence and Prevalence of Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia in Primary Care - The Triumph Project // Eur. Urology. - 2002. - Vol. 42, N 4. - Р. 323-328.

[7] Hedelin H., Bergman B., Frimodt M., Moller C., et al. Antibiotic prophylaxis in diagnostic and therapeutic urological interventions // Nord. Med. - 1995. - Vol. 110. - Р. 9-25.

[8] Wilson N. I, Lewis H. J. Survey of antibiotic prophylaxis in British urological practice // Brit. J. Urol. - 1985. - Vol. 57. - Р. 478-482.

[9] Berry A., Barratt A. Prophylactic antibiotic use in transurethral prostatic resection: a meta-analysis. // J. Urol. - 2002. - Vol. 167. - Р. 571-577.

[10] Qiang W., Jianchen W., MacDonald R. et al. Antibiotic prophylaxis for transurethral prostatic resection in men with preoperative urine containing less than 100 000 bacteria per ml: systematic review // J. Urol. - 2005. - Vol. 173. - Р. 1175-1181.

[11] Cox C. E. Comparison of intravenous ciprofloxacin and intravenous cefotaxime for antimicrobial prophylaxis in transurethral surgery // Amer. J. Med. - 1989. - Vol. 87. - Р. 252-263.

[12] Gombert M. E., du Bouchet L, Aulicino T. M., et al. Intravenous ciprofloxacin versus cefotaxime prophylaxis during transurethral surgery // Amer. J. Med. - 1989. - Vol. 87. - Р. 250-252.

[13] Christiano A. P, Hollowell C. M., Kim H. et al. Double-blind randomized comparison of single-dose ciprofloxacin versus intravenous cefazolin in patients undergoing outpatient endourologic surgery // Urology. - 2000. - Vol. 55. - Р. 182-189.

[14] Lawson K. A., Rudzinski J. K., Vicas I., Carlson K. V. Assessment of antibiotic prophylaxis prescribing patterns for TU-Р. RP: A need for Canadian guidelines? // Can. Urol. Assoc. J. - 2013. - Vol. 7. - Р. 60-79.

[15] Lukkarinen O., Hellström P., Leppilahti M. et al. Prospective randomized open study between ciprofloxacin and a combination of sulfadiazine and trimethoprim in antibiotic prophylaxis in connection with transurethral prostatectomy // Urol. Nephrol. - 1996. - Vol. 1. - Р. 33-36.

[16] Shearman C. P., Silverman S. H., Johnson M. et al. Single dose, oral antibiotic cover for transurethral prostatectomy // Brit. J. Urol. - 2008. - Vol. 62, N 5. - Р. 434-438.

RIGHTS & PERMISSIONS

Sosin I.V., Rafalskiy V.V., Shabanov P.D.