Antioxidant activity of catecholamines as a chane of them antistress effect

Abstract

The antioxidant activity of some native catecholamines (adrenaline, noradrenaline, dopamine), water-soluble antioxidant emoxipine, agonist (apomorphine) and antagonist (haloperidol) of dopamine receptors was assessed as their influence on malonic dialdehyde content and products of lipid peroxidation in homogenates and suspension of the rat cortical brain cells. All catecholamines (adrenaline, noradrenaline, dopamine in concentrations of 10-4 M and 10-5 M) possessed a high (compartable with emoxipine) antioxidant activity. The most antioxidant effect was registered in apomorphine. The inhibitory action of apomorphine on lipid peroxidation in the brain cortex can be a result from both dopamine receptor activation and “direct” antioxidant mechanism.

Keywords

catecholamines / adrenaline / noradrenaline / dopamine / emoxipine / apomorphine / haloperidol / lipid peroxidation / brain cortex / rats

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RIGHTS & PERMISSIONS

Shilov G.N., Ivanyutin V.A.