The locomotor hyperactivity in the rats,produced by 5-th type methabotropicglutamate receprors antagonist MTEP and ZnCl2 injection into rostral striatum

Abstract

The effects of 5th type of methabotropic glutamate receptors antagonist MTEP separately or with ZnCl2 multiple injection into the rostral neostriatum in chronic experiments were investigated in rats learned with condition avoidance reflexes in “schuttle box”. The two-week daily microinjection of 3 µg MTEP, similar with 1 µl saline (control group) did not influence on condition avoidance reflexes parameters and free locomotor activity in “open field”. The injection of 3 µg MTEP with ZnCl2 (1 µg /1 µl) in rostral neostriatum impaired the avoidance conditioning and locomotor hyperactivity with motor stereotypia in part of experimental animals. As separate injection as MTEP or ZnCl2 did not produce the locomotor hyperactivity, the reasone of the changed behaviour of rats was the combined action of them administered into brain substrat. The possible changs in neurotransmitter relationship provided by zinc ions striatum saturation are discussed. The hypothesis about nigro-striatal dopaminergic system activation as a general cause is proposed.

Keywords

neostriatum / condition avoidance responses / locomotor activity / ZnCl2 / MTEP

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RIGHTS & PERMISSIONS

Yakimovskiy A.F.