Search of markers of alcoholization among ghrelin derivatives
Platon Platonovich Khokhlov , Yevgeniy Rudolfovich Bychkov , Roman Olegovich Roik , Andrey Andreyevich Lebedev , Petr Dmitriyevich Shabanov
Reviews on Clinical Pharmacology and Drug Therapy ›› 2013, Vol. 11 ›› Issue (2) : 36 -40.
Search of markers of alcoholization among ghrelin derivatives
The quantitative determination of unacylated ghrelin in rat sera in the course of prolonged (chronic) alcoholization during 6 months followed by alcohol withdrawal (in 1 and 7 days) was made by means of the rat unacylated ghrelin enzyme immunoassay kit (SPIBIO, France). Unacylated ghrelin was revealed in all samples both in control and experimental groups. The row data were treated by means of parametric and nonparametric statistic tests. The level of unacylated ghrelin was shown to double reduce in the course of prolonged alcoholization in rats. Ethanol withdrawal recovered the polypeptide content gradually with maximal indexes in 7 days after alcohol abolition but lower than in control rats. The possibilities of the use of unacylated ghrelin as a biochemical marker of alcoholization and its consequences are discussed.
ghrelin / unacylated ghrelin / alcoholization / alcohol withdrawal / biochemical markers
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Khokhlov P.P., Bychkov Y.R., Roik R.O., Lebedev A.A., Shabanov P.D.
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