Expediency of application of animals with the spontaneous hypertensia for modelling of the metabolic syndrome
Maria Alexandrovna Kovaleva , Marina Nikolayevna Makarova , A. I. Selezneva , Valeriy Gennadyevich Makarov
Reviews on Clinical Pharmacology and Drug Therapy ›› 2012, Vol. 10 ›› Issue (4) : 91 -94.
Expediency of application of animals with the spontaneous hypertensia for modelling of the metabolic syndrome
When used within 11 weeks of diet “cafeteria diet” in spontaneously-hypertensive animals could lead to an increase in systolic blood pressure by 9%, sustained hyperglycemia, increased blood concentrations of triglycerides and cholesterol, as well as an increase in the relative content of visceral fat. In normotensive animals line Wistar-Kyoto prolonged use of “cafeteria diet” was accompanied only by an increase in blood glucose, cholesterol and triglycerides. Thus, the spontaneously hypertensive animals, the application of high-calorie diet demonstrated by three criteria pathogenesis of the metabolic syndrome: hyperglycemia, hypertension and visceral obesity, which allows you to use the model for the study of drugs aimed at treatment of metabolic syndrome.
spontaneously hypertensive rats / metabolic syndrome / arterial pressure
Kovaleva M.A., Makarova M.N., Selezneva A.I., Makarov V.G.
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